Role of Nuclear Receptors in Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 199
Special Issue Editors
Interests: elucidation of the involvement of nuclear receptors in the etiology of endocrine/metabolic disorders; innovation of novel drugs against endocrine/metabolic disorders by targeting nuclear receptors; identification of co-factors; post-translational modifications of nuclear receptors by LC/MS/MS
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Special Issue Information
Dear Colleagues,
Nuclear receptors include steroid/thyroid hormone receptors, metabolic sensors and orphan receptors. Metabolic sensor-type nuclear receptors, such as liver X receptor, farnesoid X receptor and peroxisome proliferator activator receptor (PPAR), are activated by oxysterol, bile acid and fatty acid, and regulate their metabolism. These receptors, like steroid hormone receptors, also regulate cellular proliferation/differentiation, and immunity. Dysregulation in these systems has been implicated in the pathogenesis of human diseases, such as cancer, cardiovascular disease, and inflammation. Moreover, nuclear receptors including PPAR, retinoid receptors, and several orphan receptors have recently been known to be involved in the etiology of metabolic syndrome and atherosclerosis. In this Special Issue, we are pleased to invite original manuscripts focusing on the relationships between nuclear receptors and human disorders, as well as novel drug innovation.
Prof. Dr. Akira Sugawara
Dr. Atsushi Yokoyama
Guest Editors
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Keywords
- retinoid receptors
- peroxisome proliferator activator receptor
- orphan receptors
- metabolic syndrome
- endocrine disorders
- liver X receptor
- vitamin D receptor
- lipid metabolism
- bile acid metabolism
- immunity
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