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Recent Research of Phytochemicals in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1156

Special Issue Editors


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Guest Editor
Nephrology Department, Indiana University School of Medicine, Indianapolis, IN, USA
Interests: chemical signaling; chemical compounds with bioactive properties such as phytochemicals and pheromones; influences of exposure to phytochemicals and pheromones on physiological conditions

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Guest Editor
Department of Anatomy, College of Medicine, Howard University, Washington, DC 20059, USA
Interests: translational medicine; drug discovery; public health; neural signaling and synaptic transmission in the central nervous system; functional organization of the olfactory and limbic system; cellular and network mechanisms of brain function and dysfunction studied with electrophysiological, optical, anatomical, and pharmacological methods
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Guest Editor
Department of Biological Sciences, Fisher College of Science and Mathematics, Towson University, Towson, MD, USA
Interests: olfactory, gustatory, and visual cues and signaling, as studied with anatomical (transmission electron microscopy and scanning electron microscopy); behavioral and electrophysiological approaches

Special Issue Information

Dear Colleagues,

Although phytochemicals have been used for medical practices for thousands of years, recently, their biological effects have been determined in detail at the molecular and gene expression level. We still need published scientific evidence to enhance our understanding of their effects and side effects in order to improve our health and recover from injuries and diseases.

Phytochemicals can be used in multiple ways, e.g., as drugs, drug carriers, supplements to suppress the degradation of drugs, or supplements to improve or maintain our health. In this Special Issue, “Recent Research of Phytochemicals in Health and Disease”, we invite papers that focus on the effects/side effects of phytochemicals, delivery methods and formulation of phytochemicals to enhance their effects, effects on brain function (anxiety, cognitive function, etc.), regeneration and wound healing, and treatment and/or prevention from diseases. Papers can also focus on the use of phytochemicals as drugs, as supplements for drugs to improve the effects of drugs, and as supplements to improve or maintain healthy conditions. To what extent phytochemicals contribute to our health Finally, there are phytochemicals with psychoactive effects, along with others that evoke allergic reactions, digestive problems, and/or fatigue. All of these topics can be addressed in original papers or reviews.

Dr. Sachiko Koyama
Prof. Dr. Thomas Heinbockel
Prof. Dr. Vonnie Shields
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • phytochemicals with bioactive properties
  • health, brain function, regeneration, wound healing, treatment, and prevention of diseases
  • delivery routes and delivery methods
  • formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability
  • drugs, supplements to drugs, and supplements for health maintenance
  • nourishment and phytochemicals
  • drug side effects
  • COVID-19

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Published Papers (1 paper)

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Review

18 pages, 683 KiB  
Review
A Comprehensive Review of Pedunculagin: Sources, Chemistry, Biological and Pharmacological Insights
by Julia Snarska, Katarzyna Jakimiuk, Jakub W. Strawa, Tomasz M. Tomczyk, Monika Tomczykowa, Jakub P. Piwowarski and Michał Tomczyk
Int. J. Mol. Sci. 2024, 25(21), 11511; https://doi.org/10.3390/ijms252111511 - 26 Oct 2024
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Abstract
Pedunculagin is a widely abundant ellagitannin found in the plant kingdom, with a chemical structure featuring two hexahydroxydiphenoyl units linked to a glucose core. It has demonstrated various biological activities, including anti-cancer, anti-inflammatory, and anti-bacterial effects. This review aims to summarize the bioactivities, [...] Read more.
Pedunculagin is a widely abundant ellagitannin found in the plant kingdom, with a chemical structure featuring two hexahydroxydiphenoyl units linked to a glucose core. It has demonstrated various biological activities, including anti-cancer, anti-inflammatory, and anti-bacterial effects. This review aims to summarize the bioactivities, chemistry, and health-promoting properties of pedunculagin and plant preparations containing it. It is the first comprehensive summary covering pedunculagin’s chemistry, sources, metabolism, and other relevant research. The search databases were Google Scholar, EBSCO Discovery Service, REAXYS Database, SCILIT, SCOPUS, PubMed, MEDLINE, Web of Science, Wiley Online Library, Science Direct/ELSEVIER, WordCat, and Taylor and Francis Online. All the databases were methodically searched for data published from 1911 until 2024. Various biological effects were proven in vitro for pedunculagin; however, due to the limited availability of the isolated compound, they have not been so far directly confirmed on more advanced in vivo and clinical models. However, its bioactivity can be deduced from studies conducted for plant preparations containing this ellagitannin as a dominant constituent, consequently indicating beneficial health effects. Further studies are needed to determine the molecular mechanism of action following topical application as well as the contribution of gut microbiota postbiotic metabolites– urolithins–being formed following the oral ingestion of preparations containing pedunculagin. Full article
(This article belongs to the Special Issue Recent Research of Phytochemicals in Health and Disease)
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