Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 125
Special Issue Editors
Interests: diatom mesoporous biosilica; hybrid functional materials; organic synthesis
Interests: microorganisms functionalization; bioorganic chemistry; bioremediation; living materials
Special Issue Information
Dear Colleagues,
The growing demand for green solutions for the development of new technologies has affected all interdisciplinary fields, ranging from materials science to biomedicine and bioremediation. In the context of the creation of biohybrid systems, green and biocompatible chemical methodologies applicable to living cell systems, such as bacteria, yeasts, and microalgae, are therefore urgently needed. Chemical functionalization, specifically intended on microbial cells, should occur through organic chemistry involving non-toxic reagents or solvents, low energy consumption, and the suitable chemical environment and adjuvants. The full versatility of organic chemistry can thus be demonstrated by performing new synthetic approaches applicable to biotechnology, biochemistry, and environmental remediation. Considering the complexity of chemical disciplines, organometallic chemistry has not yet been fully explored in this context.
In this Special Issue, researchers are invited to present their original research articles and review papers on the application of organic and organometallic methodologies with the requirements of sustainability and biocompatibility. We look forward to collecting the best selection of research on new living or bioinspired functional materials based on microorganisms or enhanced living cells, exhibiting novel properties of adhesion, resistance, metabolic outputs, or chemical xeno-productions. Special attention may be given to organic synthesis reactions occurring directly on/in living cells under biocompatible conditions (low temperature, use of oxygen or carbon dioxide, non-toxic reagents or solvents, presence of non-toxic adjuvants, use of biological buffers). These reactions may include the revisitation of classical organometallic approaches (Suzuki–Miyaura couplings, Sonogashira) or the development of new mechanistic processes, together with the use of biocompatible activators for in situ polymerizations.
Dr. Stefania Cicco
Dr. Danilo Vona
Guest Editors
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Keywords
- organometallic biochemistry
- green chemistry
- bioorthogonal
- living polymers
- living functionalization
- hybrid materials
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