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Advances in the Application of Nanoparticles for Cancer Therapy
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Advances in the Application of Nanoparticles for Cancer Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 8881

Special Issue Editor

Dr. Mateusz Wierzbicki

E-Mail Website
Guest Editor
Department of Nanobiotechnology, Institute of Biology, Warsaw University of Life Sciences, 02-787 Warsaw, Poland
Interests: nanoparticles; carbon nanoparticles; tumor biology; tumor microenvironment; angiogenesis; wound healing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The potential of nanomaterials and nanoparticles in tumor therapy or tumor therapy support applications has been widely discussed. However, the specificity of tumor diseases and the interaction of nanomaterials with tumor cells require further research. Nanomaterials have the potential to directly damage tumors through direct penetration or the production of reactive oxygen species. The unique properties of nanoparticles and the possibility of chemical modification and the attachment of active substances allow the material to be well adapted to targeted antitumor therapies. Moreover, nanomaterials can be used in drug transport systems, imaging systems, and post-operative dressings, etc.

Despite the great interest, the use of nanoparticles in antitumor therapies requires further research—in particular, regarding their biological interaction.

Therefore, authors are invited to submit original research and review articles focusing on the topics of the antitumor properties of nanoparticles and nanoparticles conjugates. Topics include, but are not limited to:

  • Toxicity
  • Advanced in vitro models for testing the interactions of nanoparticles
  • The influence of nanoparticles on cell physiology
  • The regulation of key tumor physiology processes, including migration, invasiveness, autophagy, and angiogenesis.
  • Interaction with the tumor microenvironment

Dr. Mateusz Wierzbicki
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanoparticle conjugates
  • nanoparticle toxicity
  • tumor development
  • biological pathways
  • angiogenesis
  • migration
  • invasiveness
  • autophagy
  • angiogenesis
  • tumor microenvironment

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Published Papers (3 papers)

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Research

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14 pages, 3656 KiB  
Article
Enhanced Tumor Uptake and Retention of Cyanine Dye–Albumin Complex for Tumor-Targeted Imaging and Phototherapy
by Gayoung Jo, Eun Jeong Kim and Hoon Hyun
Int. J. Mol. Sci. 2023, 24(1), 862; https://doi.org/10.3390/ijms24010862 - 3 Jan 2023
Cited by 12 | Viewed by 2441
Abstract
Heptamethine cyanine dyes are widely used for in vivo near-infrared (NIR) fluorescence imaging and NIR laser-induced cancer phototherapy due to their good optical properties. Since most of heptamethine cyanine dyes available commercially are highly hydrophobic, they can usually be used for in vivo [...] Read more.
Heptamethine cyanine dyes are widely used for in vivo near-infrared (NIR) fluorescence imaging and NIR laser-induced cancer phototherapy due to their good optical properties. Since most of heptamethine cyanine dyes available commercially are highly hydrophobic, they can usually be used for in vivo applications after formation of complexes with blood plasma proteins, especially serum albumin, to increase aqueous solubility. The complex formation between cyanine dyes and albumin improves the chemical stability and optical property of the hydrophobic cyanine dyes, which is the bottom of their practical use. In this study, the complexes between three different heptamethine cyanine dyes, namely clinically available indocyanine green (ICG), commercially available IR-786 and zwitterionic ZW800-Cl, and bovine serum albumin (BSA), were prepared to explore the effect of cyanine dyes on their tumor uptake and retention. Among the three complexes, IR-786©BSA exhibited increased tumor accumulation with prolonged tumor retention, compared to other complexes. Moreover, IR-786 bound to BSA played an important role in tumor growth suppression due to its cytotoxicity. To achieve complete tumor ablation, the tumor targeted by IR-786©BSA was further exposed to 808 nm laser irradiation for effective photothermal cancer treatment. Full article
(This article belongs to the Special Issue Advances in the Application of Nanoparticles for Cancer Therapy)
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15 pages, 1196 KiB  
Article
Fullerene Derivatives (CN-[OH]β) and Single-Walled Carbon Nanotubes Modelled as Transporters for Doxorubicin Drug in Cancer Therapy
by Hakim Al Garalleh
Int. J. Mol. Sci. 2022, 23(17), 9646; https://doi.org/10.3390/ijms23179646 - 25 Aug 2022
Cited by 4 | Viewed by 1824
Abstract
Carbon nanomaterials have received increasing attention in drug-delivery applications because of their distinct properties and structures, including large surface areas, high conductivity, low solubility in aqueous media, unique chemical functionalities, and stability at the nano-scale size. Particularly, they have been used as nano-carriers [...] Read more.
Carbon nanomaterials have received increasing attention in drug-delivery applications because of their distinct properties and structures, including large surface areas, high conductivity, low solubility in aqueous media, unique chemical functionalities, and stability at the nano-scale size. Particularly, they have been used as nano-carriers and mediators for anticancer drugs such as Cisplatin, Camptothecin, and Doxorubicin. Cancer has become the most challenging disease because it requires sophisticated therapy, and it is classified as one of the top killers according to the World Health Organization records. The aim of the current work is to study and investigate the mechanism of combination between single-walled carbon nanotubes (SWCNTs) and fullerene derivatives (CN-[OH]β) as mediators, and anticancer agents for photodynamic therapy directly to destroy the infected cells without damaging the normal ones. Here, we obtain a bio-medical model to determine the efficiency of the usefulness of Doxorubicin (DOX) as an antitumor agent conjugated with SWCNTs with variant radii r and fullerene derivative (CN-[OH]β). The two sub-models are obtained mathematically to evaluate the potential energy arising from the DOX–SWCNT and DOX-(CN-[OH]β) interactions. DOX modelled as two-connected spheres, small and large, each interacting with different SWCNTs (variant radii r) and fullerene derivatives CN-[OH]β, formed based on the number of carbon atoms (N) and the number of hydroxide molecules (OH) (β), respectively. Based on our obtained results, we find that the most favorable carbon nanomaterial is the SWCNT (r = 15.27 Å), followed by fullerene derivatives CN-(OH)22, CN-(OH)20, and CN-(OH)24, with minimum energies of −38.27, −33.72, −32.95, and −29.11 kcal/mol. Full article
(This article belongs to the Special Issue Advances in the Application of Nanoparticles for Cancer Therapy)
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Review

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15 pages, 2855 KiB  
Review
Structures and Applications of Nucleic Acid-Based Micelles for Cancer Therapy
by Haejoo Kim and Minseok Kwak
Int. J. Mol. Sci. 2023, 24(2), 1592; https://doi.org/10.3390/ijms24021592 - 13 Jan 2023
Cited by 4 | Viewed by 4076
Abstract
Nucleic acids have become important building blocks in nanotechnology over the last 30 years. DNA and RNA can sequentially build specific nanostructures, resulting in versatile drug delivery systems. Self-assembling amphiphilic nucleic acids, composed of hydrophilic and hydrophobic segments to form micelle structures, have [...] Read more.
Nucleic acids have become important building blocks in nanotechnology over the last 30 years. DNA and RNA can sequentially build specific nanostructures, resulting in versatile drug delivery systems. Self-assembling amphiphilic nucleic acids, composed of hydrophilic and hydrophobic segments to form micelle structures, have the potential for cancer therapeutics due to their ability to encapsulate hydrophobic agents into their core and position functional groups on the surface. Moreover, DNA or RNA within bio-compatible micelles can function as drugs by themselves. This review introduces and discusses nucleic acid-based spherical micelles from diverse amphiphilic nucleic acids and their applications in cancer therapy. Full article
(This article belongs to the Special Issue Advances in the Application of Nanoparticles for Cancer Therapy)
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