Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Disease, Ageing and Cancer Prevention by Natural Products
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Disease, Ageing and Cancer Prevention by Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (22 May 2021) | Viewed by 8189

Special Issue Editor

Dr. Stefania Crispi

E-Mail Website
Guest Editor
Institute of Biosciences and BioResources CNR, 80131 Naples, Italy
Interests: natural molecules; apoptosis; cell death; gene expression; miRNA; transcriptomics; biomarkers; cancer

Special Issue Information

Dear Colleagues,

In recent years, life expectancy has grown, and consequently, aged population is strongly increasing. However, aging is strictly correlated with diseases and cancer. Indeed, aging is known to be a major risk factor for cancer and disease. Starting from birth, cells in the body accumulate damages that alter organ function and allow the development of age-related diseases or cancer.

Over the last few decades, interest in natural drugs has greatly increased, since they can exert preventive effects against chronic and degenerative diseases, including cancer. In addition, these molecules play an important role in neuroprotection by modulating different cellular functions. Natural bioctive compounds can be isolated from plants, marine organisms, and from bacteria.

Natural products normally introduced with diet have been demonstrated to be able to reduce accumulation of damages and delay the onset of age-related diseases or reduce risk of developing cancer. In addition, these compounds have been shown to also be active in neurodegenerative diseases.

The pharmacological potential of natural products is related to their bioavailability that is enhanced by interaction with gut microbiota, the most dynamic populated microbial ecosystems that contribute to individual health and whose composition, strictly related to diet, changes with age.

This Special Issue will collect original research articles and review papers highlighting the different mechanisms modulated by natural products able to act against aging, cancer, and age-related diseases.

Dr. Stefania Crispi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural bioactive compounds
  • oxidative stress
  • neuroprotection
  • bioactivity
  • metabolism
  • gut microbiota
  • molecular pathway
  • cancer
  • age-related diseases

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

17 pages, 7522 KiB  
Article
4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model
by Chia-Hsin Wu, Ching-Huei Ou, I-Chuan Yen and Shih-Yu Lee
Int. J. Mol. Sci. 2020, 21(18), 6971; https://doi.org/10.3390/ijms21186971 - 22 Sep 2020
Cited by 15 | Viewed by 3966
Abstract
Astronauts suffer from 1–2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from Antrodia cinnamomea, has shown anti-inflammatory and anti-hepatoma activities. However, [...] Read more.
Astronauts suffer from 1–2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol B (4-AAQB), a ubiquinone from Antrodia cinnamomea, has shown anti-inflammatory and anti-hepatoma activities. However, the effect of 4-AAQB on μXg-induced osteoclastogenesis remains unclear. In this study, we aimed to explore the mechanistic impact of 4-AAQB on osteoclast formation under μXg conditions. The monocyte/macrophage-like cell line RAW264.7 was exposed to simulated μXg (Rotary Cell Culture System; Synthecon, Houston, TX, USA) for 24 h and then treated with 4-AAQB or alendronate (ALN) and osteoclast differentiation factor receptor activator of nuclear factor kappa-B ligand (RANKL). Osteoclastogenesis, bone resorption activity, and osteoclast differentiation-related signaling pathways were analyzed using tartrate-resistant acid phosphatase (TRAP) staining, actin ring fluorescent staining, bone resorption, and western blotting assays. Based on the results of TRAP staining, actin ring staining, and bone resorption assays, we found that 4-AAQB significantly inhibited μXg-induced osteoclast differentiation. The critical regulators of osteoclast differentiation, including nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), c-Fos, and dendritic cell-specific transmembrane protein (DC-STAMP), were consistently decreased. Meanwhile, osteoclast apoptosis and cell cycle arrest were also observed along with autophagy suppression. Interestingly, the autophagy inhibitors 3-methyladenine (3-MA) and chloroquine (CQ) showed similar effects to 4-AAQB. In conclusion, we suggest that 4-AAQB may serve as a potential agent against μXg-induced osteoclast formation. Full article
(This article belongs to the Special Issue Disease, Ageing and Cancer Prevention by Natural Products)
►▼ Show Figures

Figure 1

Review

Jump to: Research

21 pages, 663 KiB  
Review
Cancer Prevention by Natural Products Introduced into the Diet—Selected Cyclitols
by Karol Wiśniewski, Marcin Jozwik and Joanna Wojtkiewicz
Int. J. Mol. Sci. 2020, 21(23), 8988; https://doi.org/10.3390/ijms21238988 - 26 Nov 2020
Cited by 7 | Viewed by 3455
Abstract
Cancer is now the second leading cause of death worldwide. It is estimated that every year, approximately 9.6 million people die of oncologic diseases. The most common origins of malignancy are the lungs, breasts, and colorectum. Even though in recent years, many new [...] Read more.
Cancer is now the second leading cause of death worldwide. It is estimated that every year, approximately 9.6 million people die of oncologic diseases. The most common origins of malignancy are the lungs, breasts, and colorectum. Even though in recent years, many new drugs and therapeutic options have been introduced, there are still no safe, effective chemopreventive agents. Cyclitols seem poised to improve this situation. There is a body of evidence that suggests that their supplementation can decrease the incidence of colorectal cancer, lower the risk of metastasis occurrence, lower the proliferation index, induce apoptosis in malignant cells, enhance natural killer (NK) cell activity, protect cells from free radical damage, and induce positive molecular changes, as well as reduce the side effects of anticancer treatments such as chemotherapy or surgery. Cyclitol supplementation appears to be both safe and well-tolerated. This review focuses on presenting, in a comprehensive way, the currently available knowledge regarding the use of cyclitols in the treatment of different malignancies, particularly in lung, breast, colorectal, and prostate cancers. Full article
(This article belongs to the Special Issue Disease, Ageing and Cancer Prevention by Natural Products)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop