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New Advances in Human Vaccine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 March 2018) | Viewed by 8263

Special Issue Editor

Special Issue Information

Dear Colleagues,

Vaccines are one of the most powerful and effective healthcare advances ever developed. Nevertheless, the most effective vaccine candidate for an economical price is still lacking for developing-world populations. A number of factors limit complete global immunization and, among these, is the cost of procuring and distributing vaccines in lower-income countries. In this view, the topic focuses on the development of an economical vaccine candidate against infectious diseases for humans and animals for global public good. Therefore, a new strategy is required to induce a broad range of protective immunity against bacterial, fungal, or viral pathogens. Specially, we need to develop a vaccine technology platform, targeting quality, efficacy, safety, simplicity, cost-effectiveness, and affordability. Possible vaccine candidates include live attenuated vaccines, inactivated vaccines, subunit vaccines, toxoid vaccines, conjugate vaccines, DNA vaccines and recombinant vector vaccines. Possible approaches cover fundamental discovery of vaccine candidates through to their preclinical/clinical trials. In addition, the topic includes normal immunologic responses to vaccinations, patterns of abnormal responses, and methods for assessing these responses. Immune response should include a general evaluation of the immune system, including measurements of antibody levels and functional assessments of different immune cells, as well as cytokines. I wish to thank all authors for their contributions to this Special Issue.

Prof. Dr. Chang Won Choi
Guest Editor

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Keywords

  • Vaccine candidates

  • Broad range of protective immunity 

  • Vaccine technology platform 

  • Immune responses 

  • Discovery, preclinical and clinical trials

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Published Papers (1 paper)

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14 pages, 3877 KiB  
Review
HIV Vaccination: A Roadmap among Advancements and Concerns
by Maria Trovato, Luciana D’Apice, Antonella Prisco and Piergiuseppe De Berardinis
Int. J. Mol. Sci. 2018, 19(4), 1241; https://doi.org/10.3390/ijms19041241 - 19 Apr 2018
Cited by 30 | Viewed by 7708
Abstract
Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. A major success of medical research has been the development of the highly [...] Read more.
Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. A major success of medical research has been the development of the highly active antiretroviral therapy and its availability to an increasing number of people worldwide, with a considerable effect on survival. However, a safe and effective vaccine able to prevent and eradicate the HIV pandemic is still lacking. Clinical trials and preclinical proof-of-concept studies in nonhuman primate (NHP) models have provided insights into potential correlates of protection against the HIV-1 infection, which include broadly neutralizing antibodies (bnAbs), non-neutralizing antibodies targeting the variable loops 1 and 2 (V1V2) regions of the HIV-1 envelope (Env), polyfunctional antibody, and Env-specific T-cell responses. In this review, we provide a brief overview of different HIV-1 vaccine approaches and discuss the current understanding of the cellular and humoral correlates of HIV-1 immunity. Full article
(This article belongs to the Special Issue New Advances in Human Vaccine)
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