Immunological Nudging – Maintaining Vigilance and Reactivity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 7824
Special Issue Editor
Interests: ophthalmology; wound healing; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunology is regulated with regulatory systems that are fine-tuned in a constant homeostasis. The prerequisite of the ability to react immediately as needed in this system of defense is a constant availability of regulative mechanisms turning on and off in interaction with each other. Swift effective response requires anticipation. Only by constant availability of all components necessary for effective functionality of each regulatory unit is a swift immunological response in full coordination with all regulatory units possible. It is suggested to introduce the term immunological nudging, for the constant subclinical external stimuli that keep all components of the system in good functional condition and reactive capacity. Due to the constant soft push on the activation of autoregulatory mechanisms, such immunological nudging guarantees the availability of immediate immunological response ability by constantly, usually subclinically, activating and silencing each regulatory unit. It is suggested that the constant activation and deactivation of major regulatory circuits in perfect harmony maintains the readiness to immediate immunological reaction.
This Special Issue aims at gathering new research results supporting the concept of immunological nudging to broaden our understanding about adequate immunotherapy, avoiding overtreatment and identifying thresholds to adjust therapy to optimize immunological recovery.
The intention of this volume is to gather the known scientific evidence for the existence of such a regulatory immunological principle and open ways to preserve it even during immunosuppressive or anti-inflammatory treatment.
Authors are invited to submit their original research and review articles.
The following topics are relevant to this Special Issue:
- Examples of immunological homeostasis in human and veterinary medicine;
- Biochemical characterization of components engaged in the control of immunological responses;
- Clinical studies giving evidence for constant immunological activity in tissues;
- Structural and functional comparison of immunological homeostasis in different organisms;
- Proposals of effective immunosuppressive or anti-inflammatory treatment avoiding or minimizing incapacitation of immunological reactivity;
- Methods and treatments of reconstituting immunological homeostasis after intense immunosuppressive or anti-inflammatory treatment regimens;
- Studies giving evidence for the importance of neuronal functionality and neurophysiology in immunological homeostasis and nudging;
- Other relevant topics are encouraged and may be suggested.
Prof. Dr. Gysbert-Botho van Setten
Guest Editor
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Keywords
- Immunology
- Inflammatory response
- Homeostasis
- Silencing
- Activation
- Nudging
- Surface tissues
- Neurophysiology
- Immunosuppression
- Immunomodulation
- Mediators
- Therapy
- Structure and function relationship
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