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The Role of Long Non-Coding RNAs in Inflammation and Chronic...
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The Role of Long Non-Coding RNAs in Inflammation and Chronic Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 10150

Special Issue Editors

Prof. Dr. Márta Széll

E-Mail Website1 Website2
Guest Editor
Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary; MTA-SZTE Dermatological Research Group, 6720 Szeged, Hungary
Interests: psoriasis; rare diseases; multifactorial skin diseases; lncRNA; inflammation; genetic variants; signal transduction
Dr. Judit Danis

E-Mail Website
Guest Editor
MTA-SZTE Dermatological Research Group, 6720 Szeged, Hungary
Interests: lncRNA; psoriasis; inflammation; keratinocyte; innate immunity; signal transduction

Special Issue Information

Dear Colleagues,

With the completion of the human genome project, it has become obvious that protein-coding genes comprise only 2% of the genome, although the majority of the genome is transcribed into RNA. RNA molecules that lack protein-coding potential are collectively referred to as non-coding (nc) RNAs, and have gained enormous interest in biomedical research during recent years. Non-coding RNAs larger than 200 nucleotides are referred to as long non-coding (lnc) RNAs, which are markedly heterogeneous in size and cellular function. The current high throughput technology such as RNA-seq describes lncRNAs at an unprecedented level with tightly regulated expression dependent on the tissue of origin or disease condition, however, the majority of these genes is not yet functionally characterized. lncRNAs have been shown to play a fundamental role in cell growth, proliferation, cell death, invasion and metastasis formation as well as the regulation of the expression of many molecules. Currently many attempts are focusing on the use of lncRNAs as biomarkers for various diseases.
We invite investigators to contribute original research articles, as well as review articles, that will stimulate the continuing efforts in the research into lncRNAs. This Special Issue is focused on, but not limited to, the variations in expression, post-transcriptional modifications, structure, interactions, etc., of lncRNAs contributing to the regulation of cellular inflammatory functions and chronic inflammatory diseases. Both reviews and original research articles are welcome.

Prof. Dr. Márta Széll
Dr. Judit Danis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-coding RNA
  • lncRNAs
  • circRNAs
  • regulatory RNAs
  • RNA editing
  • gene regulation
  • chronic inflammatory diseases
  • inflammation

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Published Papers (2 papers)

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Review

34 pages, 2433 KiB  
Review
LncRNAs in the Type I Interferon Antiviral Response
by Beatriz Suarez, Laura Prats-Mari, Juan P. Unfried and Puri Fortes
Int. J. Mol. Sci. 2020, 21(17), 6447; https://doi.org/10.3390/ijms21176447 - 3 Sep 2020
Cited by 24 | Viewed by 5003
Abstract
The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. [...] Read more.
The proper functioning of the immune system requires a robust control over a delicate equilibrium between an ineffective response and immune overactivation. Poor responses to viral insults may lead to chronic or overwhelming infection, whereas unrestrained activation can cause autoimmune diseases and cancer. Control over the magnitude and duration of the antiviral immune response is exerted by a finely tuned positive or negative regulation at the DNA, RNA, and protein level of members of the type I interferon (IFN) signaling pathways and on the expression and activity of antiviral and proinflammatory factors. As summarized in this review, committed research during the last decade has shown that several of these processes are exquisitely regulated by long non-coding RNAs (lncRNAs), transcripts with poor coding capacity, but highly versatile functions. After infection, viruses, and the antiviral response they trigger, deregulate the expression of a subset of specific lncRNAs that function to promote or repress viral replication by inactivating or potentiating the antiviral response, respectively. These IFN-related lncRNAs are also highly tissue- and cell-type-specific, rendering them as promising biomarkers or therapeutic candidates to modulate specific stages of the antiviral immune response with fewer adverse effects. Full article
(This article belongs to the Special Issue The Role of Long Non-Coding RNAs in Inflammation and Chronic Inflammatory Diseases)
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14 pages, 1450 KiB  
Review
Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases
by Srinivasan Chinnapaiyan, Rajib Kumar Dutta, Dinesh Devadoss, Hitendra S Chand, Irfan Rahman and Hoshang Jehangir Unwalla
Int. J. Mol. Sci. 2020, 21(8), 3013; https://doi.org/10.3390/ijms21083013 - 24 Apr 2020
Cited by 9 | Viewed by 4559
Abstract
Circadian oscillations are regulated at both central and peripheral levels to maintain physiological homeostasis. The central circadian clock consists of a central pacemaker in the suprachiasmatic nucleus that is entrained by light dark cycles and this, in turn, synchronizes the peripheral clock inherent [...] Read more.
Circadian oscillations are regulated at both central and peripheral levels to maintain physiological homeostasis. The central circadian clock consists of a central pacemaker in the suprachiasmatic nucleus that is entrained by light dark cycles and this, in turn, synchronizes the peripheral clock inherent in other organs. Circadian dysregulation has been attributed to dysregulation of peripheral clock and also associated with several diseases. Components of the molecular clock are disrupted in lung diseases like chronic obstructive pulmonary disease (COPD), asthma and IPF. Airway epithelial cells play an important role in temporally organizing magnitude of immune response, DNA damage response and acute airway inflammation. Non-coding RNAs play an important role in regulation of molecular clock and in turn are also regulated by clock components. Dysregulation of these non-coding RNAs have been shown to impact the expression of core clock genes as well as clock output genes in many organs. However, no studies have currently looked at the potential impact of these non-coding RNAs on lung molecular clock. This review focuses on the ways how these non-coding RNAs regulate and in turn are regulated by the lung molecular clock and its potential impact on lung diseases. Full article
(This article belongs to the Special Issue The Role of Long Non-Coding RNAs in Inflammation and Chronic Inflammatory Diseases)
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