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Molecular Imaging in Diabetes, Obesity, and Infections 3.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 March 2023) | Viewed by 3796

Special Issue Editor


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Guest Editor
Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8542, USA
Interests: molecular imaging of fat metabolism; bone metabolism; molecular imaging of infections; clinical trials in molecular imaging and nuclear medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Molecular imaging is an exciting field that can be defined as the visualization and/or measurement of biological or biochemical processes at cellular and molecular levels. It is performed in preclinical models and in living human subjects. By necessity, molecular imaging is multidisciplinary, applying synthetic and radiochemistry, molecular biology, (patho)physiology, and multiple imaging techniques. It leverages both endogenous and exogenous imaging probes to generate detectable signals. Molecular imaging techniques include optical and optoacoustic methods, ultrasound, molecular computed tomography, magnetic resonance imaging, and spectroscopy. Molecular imaging is used to diagnose diseases, assess treatment responses, and define the underlying pathophysiology of a disease process. To this end, molecular imaging has been used to non-invasively visualize aberrant tumor metabolism, bacterial infections, beta-cell mass and function, and adipocyte metabolism. This Special Issue focuses on developing and implementing molecular imaging strategies for research in obesity, diabetes, infectious diseases, and tumor metabolism. We welcome original research and review articles.

Prof. Dr. Orhan K. Öz 
Guest Editor

Manuscript Submission Information

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Keywords

  • radionuclide probes
  • SPECT imaging
  • PET imaging
  • MRI
  • optical imaging
  • beta cells
  • diabetes
  • obesity
  • bacterial infections

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Published Papers (1 paper)

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Review

19 pages, 2077 KiB  
Review
Advances in Imaging of Inflammation, Fibrosis, and Cancer in the Gastrointestinal Tract
by Kylene M. Harold, William M. MacCuaig, Jennifer Holter-Charkabarty, Kirsten Williams, Kaitlyn Hill, Alex X. Arreola, Malika Sekhri, Steven Carter, Jorge Gomez-Gutierrez, George Salem, Girish Mishra and Lacey R. McNally
Int. J. Mol. Sci. 2022, 23(24), 16109; https://doi.org/10.3390/ijms232416109 - 17 Dec 2022
Cited by 10 | Viewed by 3410
Abstract
Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly emerging technologies such as optoacoustic imaging, many [...] Read more.
Gastrointestinal disease is prevalent and broad, manifesting itself in a variety of ways, including inflammation, fibrosis, infection, and cancer. However, historically, diagnostic technologies have exhibited limitations, especially with regard to diagnostic uncertainty. Despite development of newly emerging technologies such as optoacoustic imaging, many recent advancements have focused on improving upon pre-existing modalities such as ultrasound, computed tomography, magnetic resonance imaging, and endoscopy. These advancements include utilization of machine learning models, biomarkers, new technological applications such as diffusion weighted imaging, and new techniques such as transrectal ultrasound. This review discusses assessment of disease processes using imaging strategies for the detection and monitoring of inflammation, fibrosis, and cancer in the context of gastrointestinal disease. Specifically, we include ulcerative colitis, Crohn’s disease, diverticulitis, celiac disease, graft vs. host disease, intestinal fibrosis, colorectal stricture, gastric cancer, and colorectal cancer. We address some of the most recent and promising advancements for improvement of gastrointestinal imaging, including unique discussions of such advancements with regard to imaging of fibrosis and differentiation between similar disease processes. Full article
(This article belongs to the Special Issue Molecular Imaging in Diabetes, Obesity, and Infections 3.0)
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