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Nanomaterials for Theranostics and Tissue Engineering Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 11850

Special Issue Editor


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Guest Editor
CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy
Interests: regenerative medicine; tissue engineering; nanomedicine; biotechnology; biomaterials; stem cells
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Special Issue Information

Dear Colleagues,

In recent years, nanomaterials are emerging as promising agents for both therapeutic and diagnostic (theranostic) applications, and also for their possible use in tissue engineering and regenerative medicine. Research efforts are moving towards the exploration of new materials that can foster the clinical translation of biotechnological approaches aimed at non-invasive imaging, biomarker development and drug targeting. Many types of nanomaterials, including nanoparticles, quantum dots and nanostructures, have shown both diagnostic and therapeutic potential that strongly depend on size control and surface modification. These aspects can influence biocompatibility and interactions with biological systems. A key element for research on theranostic agents in the near future is the need to improve disease detection and therapeutic efficacy.

This Special Issue on “Nanomaterials for Theranostics and tissue Engineering Applications” welcomes original research and reviews in nanomedicine and nanotechnology field, with a focus on all aspects of design, characterization, evaluation, and development of novel nanomaterial and nanotechnology for medicine applications and the challenges of their use, both from a diagnostic and a therapeutic point of view.

We would like to focus on the following concepts:

  • Study, design, characterization and development of biosensors and theragnostic platforms based on advanced nanostructured systems.
  • New intelligent biomaterials and nano-structured devices, functionalized metal nanoparticles and polymeric devices for imaging, tissue engineering, organ on chip, stem cell therapy and drug delivery;

Acoustic, optical and electrical nano-biosensors and advanced microfluidic devices and lab-on-chip for bioanalytics, diagnostics, drug testing and drug discovery

Dr. Mario Ledda
Guest Editor

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Keywords

  • nanomaterial
  • nanotechnology
  • intelligent biomaterials
  • drug testing
  • drug discovery
  • drug delivery
  • theragnostic platforms
  • biosensing
  • tissue engineering

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Published Papers (3 papers)

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Research

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15 pages, 28358 KiB  
Article
MIL-100(Fe) Sub-Micrometric Capsules as a Dual Drug Delivery System
by Marina Paiva Abuçafy, Regina Celia Galvao Frem, Giulia Polinario, Fernando Rogerio Pavan, Heng Zhao, Angelika Mielcarek, Cedric Boissiere, Christian Serre and Leila Aparecida Chiavacci
Int. J. Mol. Sci. 2022, 23(14), 7670; https://doi.org/10.3390/ijms23147670 - 12 Jul 2022
Cited by 9 | Viewed by 3181
Abstract
Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) [...] Read more.
Nanoparticles of metal–organic frameworks (MOF NPs) are crystalline hybrid micro- or mesoporous nanomaterials that show great promise in biomedicine due to their significant drug loading ability and controlled release. Herein, we develop porous capsules from aggregate of nanoparticles of the iron carboxylate MIL-100(Fe) through a low-temperature spray-drying route. This enables the concomitant one-pot encapsulation of high loading of an antitumor drug, methotrexate, within the pores of the MOF NPs, and the collagenase enzyme (COL), inside the inter-particular mesoporous cavities, upon the formation of the capsule, enhancing tumor treatment. This association provides better control of the release of the active moieties, MTX and collagenase, in simulated body fluid conditions in comparison with the bare MOF NPs. In addition, the loaded MIL-100 capsules present, against the A-375 cancer cell line, selective toxicity nine times higher than for the normal HaCaT cells, suggesting that MTX@COL@MIL-100 capsules may have potential application in the selective treatment of cancer cells. We highlight that an appropriate level of collagenase activity remained after encapsulation using the spray dryer equipment. Therefore, this work describes a novel application of MOF-based capsules as a dual drug delivery system for cancer treatment. Full article
(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)
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16 pages, 20848 KiB  
Article
Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
by Dmitry V. Korolev, Galina A. Shulmeyster, Natalia V. Evreinova, Maria S. Syrovatkina, Maria S. Istomina, Victor N. Postnov, Ilia V. Aleksandrov, Aleksandr S. Krasichkov and Michael M. Galagudza
Int. J. Mol. Sci. 2022, 23(2), 932; https://doi.org/10.3390/ijms23020932 - 15 Jan 2022
Cited by 1 | Viewed by 2317
Abstract
In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes [...] Read more.
In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals. Full article
(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)
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Review

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25 pages, 6725 KiB  
Review
Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles
by Elena G. Varlamova, Egor A. Turovsky and Ekaterina V. Blinova
Int. J. Mol. Sci. 2021, 22(19), 10808; https://doi.org/10.3390/ijms221910808 - 6 Oct 2021
Cited by 60 | Viewed by 5244
Abstract
This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium [...] Read more.
This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review. Full article
(This article belongs to the Special Issue Nanomaterials for Theranostics and Tissue Engineering Applications)
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