Noncoding RNAs as New Instruments in the Orchestration of Cell Death and Cancer Therapy Resistance 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 6746
Special Issue Editors
Interests: cell death mechanisms; microRNAs; long non coding RNAs; biomarkers; nanotechnology; drug delivery; signal transduction; target therapy; cancer; circulating tumor cells; glioblastoma; prostate cancer; hepatocellular cancer
Special Issues, Collections and Topics in MDPI journals
Interests: microRNAs; long non-coding RNAs; extracellular vesicles; regulation of gene expression; cell death mechanisms; cell signaling; cancer therapy; drug delivery systems; target therapy; immunotherapy; prostate cancer; colorectal cancer; glioblastoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Noncoding RNAs (ncRNAs) are emerging as key orchestrators of tumorigenesis. Recent advances in biotechnologies, such as high-throughput sequencing, genome editing, and mouse modeling, have allowed for functional studies of ncRNAs to provide new perspectives in the fight against cancer. In addition to miRNAs and lncRNAs, that play a key role in the regulation of gene expression, other novel ncRNAs, such as transfer RNA (tRNA) fragments, snoRNA-related lncRNAs (sno-lncRNAs), and circRNAs have also appeared on the radar of cancer researchers. Increasing evidence shows that ncRNAs function either as tumor suppressors or oncogenes by regulating one or several cancer hallmarks, including evading cell death, metastasis, and drug resistance. Cancer therapy resistance is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complex and result from multiple factors. Among them, ncRNAs have been shown to regulate drug resistance by targeting drug resistance-related genes or influencing genes related to cell proliferation and cell death. Indeed, ncRNAs target and inhibit the expression of several cellular regulators, including those controlling programmed cell death via the intrinsic and extrinsic, p53-, and endoplasmic reticulum (ER) stress-induced apoptotic pathways, as well as pathways of necroptosis, mitophagy, and autophagy.
This Special issue will focus on the recent advances in “Noncoding RNAs as New Instruments in the Orchestration of Cell Death and Cancer Therapy Resistance”, including new findings concerning ncRNAs that modulate apoptosis, autophagy, and other programmed cell death and cancer resistance pathways, as well as emerging data on miRNA–lncRNA interactions that affect cell death regulation and mechanisms of resistance to therapy. Current research progress on ncRNAs for clinical and/or potential translational applications, including the identification of novel therapeutic approaches for ncRNA targeting and delivery strategies, will be also appreciated.
Dr. Silvia Zappavigna
Dr. Amalia Luce
Guest Editors
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Keywords
- regulatory ncRNAs
- cell death mechanisms
- cancer therapy
- cancer resistance
- ncRNA based-therapy
- ncRNA deregulation
- delivery strategies
- miRNA/lncRNA interactions
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