Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Silver Nano/microparticles: Modification and Applications

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Related Special Issue
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (28 January 2019) | Viewed by 139041

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special issue Silver Nano/microparticles: Modification and Applications book cover image

Share This Special Issue

Special Issue Editors

Prof. Dr. Bong-Hyun Jun

E-Mail Website
Guest Editor

Department of Bioscience and Biotechnology, Konkuk University, Gwangjin-gu, Seoul, Republic of Korea
Interests: SERS; optical materials; nanomaterials; applications
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Won Yeop Rho

E-Mail Website
Co-Guest Editor

School of International Engineering and Science, Jeonbuk National University, Jeonju 54896, Republic of Korea
Interests: DSSC; solar cell; nanomaterials; applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, nano/microparticles are widely used in various fields. Silver particles are one of the most vital materials among the various particles, due to their unique optical-physical-chemical properties. The materials have been proposed for various fields such as bio-sensor, diagnostics, imaging, catalyst and antibacterial. Especially, size-dependent unique plasmonic properties make the particles superior in biomedical applications.

This special issue is aimed to provide a range of original contributions detailing the synthesis, modification, properties and applications in different areas of silver materials, particularly in nanomedicine.

Prof. Bong-Hyun Jun
Prof. Won Yeop Rho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Ag nanoparticles
Ag microparticles
Plasmonic nanoparticles
Biosensor
Diagnostics
Imaging
Bio applications
Optical property
Catalyst
Antibacterial

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Related Special Issue

Silver Nano/Microparticles: Modification and Applications 2.0 in International Journal of Molecular Sciences (12 articles)

Published Papers (10 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Editorial

Jump to: Research, Review

3 pages, 160 KiB

Open AccessEditorial

Silver Nano/Microparticles: Modification and Applications

by Bong-Hyun Jun

Int. J. Mol. Sci. 2019, 20(11), 2609; https://doi.org/10.3390/ijms20112609 - 28 May 2019

Cited by 17 | Viewed by 3623

Abstract

Nano/micro-size particles are widely applied in various fields [...] Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

Research

Jump to: Editorial, Review

13 pages, 2303 KiB

Open AccessArticle

Control of Silver Coating on Raman Label Incorporated Gold Nanoparticles Assembled Silica Nanoparticles

by Xuan-Hung Pham, Eunil Hahm, Eunji Kang, Byung Sung Son, Yuna Ha, Hyung-Mo Kim, Dae Hong Jeong and Bong-Hyun Jun

Int. J. Mol. Sci. 2019, 20(6), 1258; https://doi.org/10.3390/ijms20061258 - 13 Mar 2019

Cited by 27 | Viewed by 6651

Abstract

Signal reproducibility in surface-enhanced Raman scattering (SERS) remains a challenge, limiting the scope of the quantitative applications of SERS. This drawback in quantitative SERS sensing can be overcome by incorporating internal standard chemicals between the core and shell structures of metal nanoparticles (NPs). Herein, we prepared a SERS-active core Raman labeling compound (RLC) shell material, based on Au–Ag NPs and assembled silica NPs (SiO₂@Au@RLC@Ag NPs). Three types of RLCs were used as candidates for internal standards, including 4-mercaptobenzoic acid (4-MBA), 4-aminothiophenol (4-ATP) and 4-methylbenzenethiol (4-MBT), and their effects on the deposition of a silver shell were investigated. The formation of the Ag shell was strongly dependent on the concentration of the silver ion. The negative charge of SiO₂@Au@RLCs facilitated the formation of an Ag shell. In various pH solutions, the size of the Ag NPs was larger at a low pH and smaller at a higher pH, due to a decrease in the reduction rate. The results provide a deeper understanding of features in silver deposition, to guide further research and development of a strong and reliable SERS probe based on SiO₂@Au@RLC@Ag NPs. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Graphical abstract

15 pages, 2626 KiB

Open AccessArticle

Size-Dependent Effect of Silver Nanoparticles on the Tumor Necrosis Factor α-Induced DNA Damage Response

by Alaa Fehaid and Akiyoshi Taniguchi

Int. J. Mol. Sci. 2019, 20(5), 1038; https://doi.org/10.3390/ijms20051038 - 27 Feb 2019

Cited by 30 | Viewed by 3878

Abstract

Silver nanoparticles (AgNPs) are widely used in many consumer products due to their anti-inflammatory properties. Therefore, the effect of exposure to AgNPs should be investigated in diseased states in addition to healthy ones. Tumor necrosis factor-α (TNFα) is a major cytokine that is highly expressed in many diseased conditions, such as inflammatory diseases, sepsis, and cancer. We investigated the effects of two different sizes of AgNPs on the TNFα-induced DNA damage response. Cells were exposed to 10 and 200 nm AgNPs separately and the results showed that the 200 nm AgNPs had a lower cytotoxic effect with a higher percent of cellular uptake compared to the 10 nm AgNPs. Moreover, analysis of reactive oxygen species (ROS) generation and DNA damage indicated that TNFα-induced ROS-mediated DNA damage was reduced by 200 nm AgNPs, but not by 10 nm AgNPs. Tumor necrosis factor receptor 1 (TNFR1) was localized on the cell surface after TNFα exposure with or without 10 nm AgNPs. In contrast, the expression of TNFR1 on the cell surface was reduced by the 200 nm AgNPs. These results suggested that exposure of cells to 200 nm AgNPs reduces the TNFα-induced DNA damage response via reducing the surface expression of TNFR1, thus reducing the signal transduction of TNFα. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Figure 1

10 pages, 3058 KiB

Open AccessArticle

Functionalized β-Cyclodextrin Immobilized on Ag-Embedded Silica Nanoparticles as a Drug Carrier

by Eun Ji Kang, Yu Mi Baek, Eunil Hahm, Sang Hun Lee, Xuan-Hung Pham, Mi Suk Noh, Dong-Eun Kim and Bong-Hyun Jun

Int. J. Mol. Sci. 2019, 20(2), 315; https://doi.org/10.3390/ijms20020315 - 14 Jan 2019

Cited by 20 | Viewed by 6377

Abstract

Cyclodextrins (CDs) have beneficial characteristics for drug delivery, including hydrophobic interior surfaces. Nanocarriers with β-CD ligands have been prepared with simple surface modifications as drug delivery vehicles. In this study, we synthesized β-CD derivatives on an Ag-embedded silica nanoparticle (NP) (SiO₂@Ag NP) structure to load and release doxorubicin (DOX). Cysteinyl-β-CD and ethylenediamine-β-CD (EDA-β-CD) were immobilized on the surface of SiO₂@Ag NPs, as confirmed by transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis) spectrophotometry, and Fourier transform infrared (FTIR) spectroscopy. DOX was introduced into the β-CD on the SiO₂@Ag NPs and then successfully released. Neither cysteinyl-β-CD and EDA-β-CD showed cytotoxicity, while DOX-loaded cysteinyl-β-CD and EDA-β-CD showed a significant decrease in cell viability in cancer cells. The SiO₂@Ag NPs with β-CD provide a strategy for designing a nanocarrier that can deliver a drug with controlled release from modified chemical types. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Figure 1

20 pages, 3866 KiB

Open AccessArticle

Studies on Silver Ions Releasing Processes and Mechanical Properties of Surface-Modified Titanium Alloy Implants

by Aleksandra Radtke, Marlena Grodzicka, Michalina Ehlert, Tadeusz M. Muzioł, Marek Szkodo, Michał Bartmański and Piotr Piszczek

Int. J. Mol. Sci. 2018, 19(12), 3962; https://doi.org/10.3390/ijms19123962 - 9 Dec 2018

Cited by 22 | Viewed by 4464

Abstract

Dispersed silver nanoparticles (AgNPs) on the surface of titanium alloy (Ti6Al4V) and titanium alloy modified by titania nanotube layer (Ti6Al4V/TNT) substrates were produced by the chemical vapor deposition method (CVD) using a novel precursor of the formula [Ag₅(O₂CC₂F₅)₅(H₂O)₃]. The structure and volatile properties of this compound were determined using single crystal X-ray diffractometry, variable temperature IR spectrophotometry (VT IR), and electron inducted mass spectrometry (EI MS). The morphology and the structure of the produced Ti6Al4V/AgNPs and Ti6Al4V/TNT/AgNPs composites were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Moreover, measurements of hardness, Young’s modulus, adhesion, wettability, and surface free energy have been carried out. The ability to release silver ions from the surface of produced nanocomposite materials immersed in phosphate-buffered saline (PBS) solution has been estimated using inductively coupled plasma mass spectrometry (ICP-MS). The results of our studies proved the usefulness of the CVD method to enrich of the Ti6Al4V/TNT system with silver nanoparticles. Among the studied surface-modified titanium alloy implants, the better nano-mechanical properties were noticed for the Ti6Al4V/TNT/AgNPs composite in comparison to systems non-enriched by AgNPs. The location of silver nanoparticles inside of titania nanotubes caused their lowest release rate, which may indicate suitable properties on the above-mentioned type of the composite for the construction of implants with a long term antimicrobial activity. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Graphical abstract

16 pages, 6692 KiB

Open AccessArticle

Polydopamine-Assisted Silver Nanoparticle Self-Assembly on Sericin/Agar Film for Potential Wound Dressing Application

by Liying Liu, Rui Cai, Yejing Wang, Gang Tao, Lisha Ai, Peng Wang, Meirong Yang, Hua Zuo, Ping Zhao and Huawei He

Int. J. Mol. Sci. 2018, 19(10), 2875; https://doi.org/10.3390/ijms19102875 - 21 Sep 2018

Cited by 68 | Viewed by 6446

Abstract

Silver nanoparticles (AgNPs) are extensively applied for their broad-spectrum and excellent antibacterial ability in recent years. Polydopamine (PDA) has great advantages for synthesizing large amounts of AgNPs, as it has multiple sites for silver ion binding and phenolic hydroxyl structure to reduce silver ions to AgNPs. Here, we mixed sericin and agar solution and dried at 65 °C to prepare a sericin (SS)/Agar composite film, and then coated polydopamine (PDA) on the surface of SS/Agar film by soaking SS/Agar film into polydopamine solution, subsequently synthesizing high-density AgNPs with the assistance of PDA to yield antibacterial AgNPs-PDA- SS/Agar film. Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) spectra indicated the successful synthesis of high-density AgNPs on the surface of PDA-SS/Agar film. PDA coating and AgNPs modification did not affect the structure of sericin and agar. Furthermore, water contact angle, water absorption and mechanical property analysis showed that AgNPs-PDA-SS/Agar film had excellent hydrophilicity and proper mechanical properties. Inhibition zone and growth curve assays suggested the prepared film had excellent and long-lasting antibacterial ability. In addition, it had excellent cytocompatibility on the fibroblast NIH/3T3 cells. The film shows great potential as a novel kind of wound dressing. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Figure 1

Review

Jump to: Editorial, Research

28 pages, 5775 KiB

Open AccessReview

Silver Nanoparticles Based Ink with Moderate Sintering in Flexible and Printed Electronics

by Lixin Mo, Zhenxin Guo, Li Yang, Qingqing Zhang, Yi Fang, Zhiqing Xin, Zheng Chen, Kun Hu, Lu Han and Luhai Li

Int. J. Mol. Sci. 2019, 20(9), 2124; https://doi.org/10.3390/ijms20092124 - 29 Apr 2019

Cited by 98 | Viewed by 11457

Abstract

Printed electronics on flexible substrates has attracted tremendous research interest research thanks its low cost, large area production capability and environmentally friendly advantages. Optimal characteristics of silver nanoparticles (Ag NPs) based inks are crucial for ink rheology, printing, post-print treatment, and performance of the printed electronics devices. In this review, the methods and mechanisms for obtaining Ag NPs based inks that are highly conductive under moderate sintering conditions are summarized. These characteristics are particularly important when printed on temperature sensitive substrates that cannot withstand sintering of high temperature. Strategies to tailor the protective agents capping on the surface of Ag NPs, in order to optimize the sizes and shapes of Ag NPs as well as to modify the substrate surface, are presented. Different (emerging) sintering technologies are also discussed, including photonic sintering, electrical sintering, plasma sintering, microwave sintering, etc. Finally, applications of the Ag NPs based ink in transparent conductive film (TCF), thin film transistor (TFT), biosensor, radio frequency identification (RFID) antenna, stretchable electronics and their perspectives on flexible and printed electronics are presented. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Graphical abstract

21 pages, 861 KiB

Open AccessReview

Impacts of Silver Nanoparticles on Plants: A Focus on the Phytotoxicity and Underlying Mechanism

by An Yan and Zhong Chen

Int. J. Mol. Sci. 2019, 20(5), 1003; https://doi.org/10.3390/ijms20051003 - 26 Feb 2019

Cited by 343 | Viewed by 18194

Abstract

Nanotechnology was well developed during past decades and implemented in a broad range of industrial applications, which led to an inevitable release of nanomaterials into the environment and ecosystem. Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials in various fields, especially in the agricultural sector. Plants are the basic component of the ecosystem and the most important source of food for mankind; therefore, understanding the impacts of AgNPs on plant growth and development is crucial for the evaluation of potential environmental risks on food safety and human health imposed by AgNPs. The present review summarizes uptake, translocation, and accumulation of AgNPs in plants, and exemplifies the phytotoxicity of AgNPs on plants at morphological, physiological, cellular, and molecular levels. It also focuses on the current understanding of phytotoxicity mechanisms via which AgNPs exert their toxicity on plants. In addition, the tolerance mechanisms underlying survival strategy that plants adopt to cope with adverse effects of AgNPs are discussed. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Figure 1

24 pages, 3456 KiB

Open AccessReview

Silver Nanoparticles: Synthesis and Application for Nanomedicine

by Sang Hun Lee and Bong-Hyun Jun

Int. J. Mol. Sci. 2019, 20(4), 865; https://doi.org/10.3390/ijms20040865 - 17 Feb 2019

Cited by 1032 | Viewed by 48876

Abstract

Over the past few decades, metal nanoparticles less than 100 nm in diameter have made a substantial impact across diverse biomedical applications, such as diagnostic and medical devices, for personalized healthcare practice. In particular, silver nanoparticles (AgNPs) have great potential in a broad range of applications as antimicrobial agents, biomedical device coatings, drug-delivery carriers, imaging probes, and diagnostic and optoelectronic platforms, since they have discrete physical and optical properties and biochemical functionality tailored by diverse size- and shape-controlled AgNPs. In this review, we aimed to present major routes of synthesis of AgNPs, including physical, chemical, and biological synthesis processes, along with discrete physiochemical characteristics of AgNPs. We also discuss the underlying intricate molecular mechanisms behind their plasmonic properties on mono/bimetallic structures, potential cellular/microbial cytotoxicity, and optoelectronic property. Lastly, we conclude this review with a summary of current applications of AgNPs in nanoscience and nanomedicine and discuss their future perspectives in these areas. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Figure 1

47 pages, 26702 KiB

Open AccessReview

Bactericidal and Cytotoxic Properties of Silver Nanoparticles

by Chengzhu Liao, Yuchao Li and Sie Chin Tjong

Int. J. Mol. Sci. 2019, 20(2), 449; https://doi.org/10.3390/ijms20020449 - 21 Jan 2019

Cited by 700 | Viewed by 27754

Abstract

Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent antimicrobial properties. Accordingly, AgNPs have gained access into our daily life, and the inevitable human exposure to these nanoparticles has raised concerns about their potential hazards to the environment, health, and safety in recent years. From in vitro cell cultivation tests, AgNPs have been reported to be toxic to several human cell lines including human bronchial epithelial cells, human umbilical vein endothelial cells, red blood cells, human peripheral blood mononuclear cells, immortal human keratinocytes, liver cells, etc. AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes ≤10 nm. Furthermore, AgNPs can cross the brain blood barrier of mice through the circulation system on the basis of in vivo animal tests. AgNPs tend to accumulate in mice organs such as liver, spleen, kidney and brain following intravenous, intraperitoneal, and intratracheal routes of administration. In this respect, AgNPs are considered a double-edged sword that can eliminate microorganisms but induce cytotoxicity in mammalian cells. This article provides a state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings. Particular attention is paid to the bactericidal activity and cytotoxic effect in mammalian cells. Full article

(This article belongs to the Special Issue Silver Nano/microparticles: Modification and Applications)

► Show Figures

Journal Menu

Journal Browser

Silver Nano/microparticles: Modification and Applications

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Related Special Issue

Published Papers (10 papers)

Editorial

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI