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Inorganics
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Functional Inorganic Materials for Biomedical Application
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Functional Inorganic Materials for Biomedical Application

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Inorganic Materials".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 12073

Special Issue Editor

Dr. Yue Wang

E-Mail Website
Guest Editor
Key Laboratary of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University, Nanjing 211198, China
Interests: inorganic nanomaterial; nanomedicine; anti-tumor; target drug delivery; diagnostic reagents
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inorganic nanomaterials have attracted substantial research efforts due to their rich compositional and structural diversity as well as their broad possible applications. Besides their multifunctional usages as effective catalysts, magnetic materials and photoelectric materials, especially some metal-containing nanomaterials, can be used as new nanomedicines with biological activities, delivery vehicles for target drug delivery or controlled drug release, and good diagnostic reagents in the pharmaceutical field. Hence, discovering multimodal inorganic nanomaterials is of great importance in improving the progress of biomedicine research.

In this Special Issue, we wish to cover the most recent advances in all these aspects of inorganic nanomaterials by publishing a mix of original research articles and short critical reviews.

Dr. Yue Wang
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic nanomaterial
  • nanomedicine
  • drug delivery
  • diagnostic

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Published Papers (5 papers)

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Research

18 pages, 9756 KiB  
Article
Investigation of In Vitro Anticancer and Apoptotic Potential of Biofabricated Silver Nanoparticles from Cardamine hirsuta (L.) Leaf Extract against Caco-2 Cell Line
by Halaswamy Hire Math, Kariyellappa Nagaraja Shashiraj, Raju Suresh Kumar, Muthuraj Rudrappa, Meghashyama Prabhakara Bhat, Dhanyakumara Shivapoojar Basavarajappa, Abdulrahman I. Almansour, Karthikeyan Perumal and Sreenivasa Nayaka
Inorganics 2023, 11(8), 322; https://doi.org/10.3390/inorganics11080322 - 31 Jul 2023
Cited by 20 | Viewed by 1978
Abstract
Green nanoparticle (NPs) synthesis is eco-friendly, non-toxic, and the NPs have demonstrated improved biocompatibility for use in healthcare. This study evaluated the biogenic synthesis of AgNPs from the leaves of Cardamine hirsuta L. and their biological properties. The UV-Vis. spectra at 411 nm [...] Read more.
Green nanoparticle (NPs) synthesis is eco-friendly, non-toxic, and the NPs have demonstrated improved biocompatibility for use in healthcare. This study evaluated the biogenic synthesis of AgNPs from the leaves of Cardamine hirsuta L. and their biological properties. The UV-Vis. spectra at 411 nm exhibited a distinct resonance spectrum for C-AgNPs produced from C. hirsuta L. FT-IR analysis exhibited the presence of functional groups of phyto-compounds of C. hirsuta responsible of silver salt reduction and capping agents of C-AgNPs. The microscopic-based study, such as HR-TEM analysis, showed that the particles were uniformly distributed, spherical, and ranged in size from 5.36 to 87.65 nm. EDX analysis confirmed a silver (Ag) content of 36.3% by weight, and XRD analysis exhibited the face-centred cubic (FCC) crystalline nature of C-AgNPs. DLS measured the mean particle size of 76.5 nm. The zeta potential was significant at −27.9 mV, and TGA analysis revealed that C-AgNPs had higher thermal stability. C-AgNPs demonstrated moderate antimicrobial activity against the tested pathogens. In addition, the anti-proliferative activity measured by the MTT assay on the Caco-2 cell line demonstrated decreased cell viability with increasing C-AgNPs dosage, with an IC50 concentration of 49.14 µg/mL. In addition, an Annexin-V/Propidium iodide flow cytometric study was utilized to evaluate the induction of apoptosis in cancer cells. Early and late apoptosis cell populations increased significantly compared to the untreated control. Therefore, green-synthesized C-AgNPs have significant antimicrobial and anti-proliferative abilities, making them intriguing options for future biomedical applications. Full article
(This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application)
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17 pages, 3736 KiB  
Article
Stem Bark-Mediated Green Synthesis of Silver Nanoparticles from Pyrus pashia: Characterization, Antioxidant, and Antibacterial Properties
by Lekha Nath Khanal, Purna Prasad Dhakal, Mani Ram Kandel, Debendra Acharya, Ek Raj Baral, Kisan Chhetri and Surya Kant Kalauni
Inorganics 2023, 11(6), 263; https://doi.org/10.3390/inorganics11060263 - 20 Jun 2023
Cited by 4 | Viewed by 2370
Abstract
The investigation of using medicinal plants for the production and application of silver nanoparticles (AgNPs) has attracted growing research interest. In this study, AgNPs are synthesized from the stem barks of the Pyrus pashia medicinal plant using a biosynthetic strategy. The reaction conditions [...] Read more.
The investigation of using medicinal plants for the production and application of silver nanoparticles (AgNPs) has attracted growing research interest. In this study, AgNPs are synthesized from the stem barks of the Pyrus pashia medicinal plant using a biosynthetic strategy. The reaction conditions were optimized under ambient conditions, including concentration, temperature, time, and pH, and various techniques were employed, such as UV-visible, FTIR, XRD, FESEM, and TEM, to characterize the synthesized AgNPs. The AgNPs produced through this biosynthesis method were found to be spherical and polydispersed, with an average size of 23.92 ± 7.04 nm. The synthesized AgNPs demonstrated an enhanced DPPH free radical scavenging capacity compared to the aqueous extract, with IC50 values of 10.67 ± 0.05 µg/mL and 13.66 ± 0.35 µg/mL, respectively. In the agar well diffusion method, the synthesized AgNPs showed higher antibacterial activity than that of the extract against Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 29212), Salmonella typhi (ATCC 14028), and Shigella sonnei (ATCC 25931). Based on these findings, the study suggests that green synthesized AgNPs from P. pashia could be used for biomedical applications. Full article
(This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application)
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21 pages, 4633 KiB  
Article
Synthesis and Characterization of Green Zinc-Metal-Pillared Bentonite Mediated Curcumin Extract (Zn@CN/BE) as an Enhanced Antioxidant and Anti-Diabetes Agent
by Stefano Bellucci, Hassan Ahmed Rudayni, Marwa H. Shemy, Malak Aladwani, Lina M. Alneghery, Ahmed A. Allam and Mostafa R. Abukhadra
Inorganics 2023, 11(4), 154; https://doi.org/10.3390/inorganics11040154 - 2 Apr 2023
Cited by 1 | Viewed by 1962
Abstract
Green zinc-metal-pillared bentonite mediated curcumin extract (Zn@CN/BE) was synthesized and characterized as a low-cost and multifunctional (curcumin-based phytochemicals, zinc-capped curcumin, zinc/curcumin complexes, and zinc-pillared bentonite) antioxidant and antidiabetic agent with enhanced activity. The activities of the Zn@CN/BE structure were assessed in comparison with [...] Read more.
Green zinc-metal-pillared bentonite mediated curcumin extract (Zn@CN/BE) was synthesized and characterized as a low-cost and multifunctional (curcumin-based phytochemicals, zinc-capped curcumin, zinc/curcumin complexes, and zinc-pillared bentonite) antioxidant and antidiabetic agent with enhanced activity. The activities of the Zn@CN/BE structure were assessed in comparison with curcumin and ZnO as individual components and in the presence of miglitol and acarbose commercial drugs as controls. The structure validated remarkable antioxidant activities against the common oxidizing radicals (nitric oxide (94.7 ± 1.83%), DPPH (96.4 ± 1.63%), ABTS (92.8 ± 1.33%), and superoxide (62.3 ± 1.63 %)) and inhibition activities against the main oxidizing enzymes (porcine α-amylase (89.3 ± 1.13%), murine α-amylase (70.8 ± 1.54%), pancreatic α-Glucosidase (99.3 ± 1.23%), intestinal α-Glucosidase (97.7 ± 1.24%), and amyloglucosidase (98.4 ± 1.64%)). The reported activities are higher than the activities of individual components and the studied ascorbic acid as well as the commercial drugs. This enhancement effect was assigned to the impact of the zinc pillaring process within the curcumin/bentonite host, which induced the stability, dispersions, and interactive interface of the essential active compounds in addition to the solubility and release rate of the intercalated curcumin extract. This paper recommends the application of the Zn@CN/BE structure as an enhanced, low-cost, biocompatible, safe, and simply produced antioxidant and antidiabetic agent. Full article
(This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application)
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16 pages, 3085 KiB  
Article
Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation
by Mansoura Bourwina, Sandra Walha, Najeh Krayem, Riadh Badraoui, Faten Brahmi, Wejdan M. Alshammari, Mejdi Snoussi, Mark M. Turnbull, Thierry Roisnel and Houcine Naïli
Inorganics 2023, 11(2), 76; https://doi.org/10.3390/inorganics11020076 - 4 Feb 2023
Cited by 2 | Viewed by 2093
Abstract
A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C5H14N2)[MnCl4(H2O)2 [...] Read more.
A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C5H14N2)[MnCl4(H2O)2] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl4(H2O)2]2−. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses. Full article
(This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application)
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7 pages, 4819 KiB  
Article
Green Synthesis of Anti-bacterial Nano Silver by Polysaccharide from Bletilla Striata
by Jiahao Zhang, Yunxue Yin, Shuo Hu, Guangyu Wang, Yuxin Tong, Mingyang Zen, Zhile Liang, Minghao Li, Ran Yan and Yue Wang
Inorganics 2023, 11(1), 40; https://doi.org/10.3390/inorganics11010040 - 12 Jan 2023
Cited by 6 | Viewed by 2379
Abstract
The silver nanoparticle is a good antibacterial material being used as a broad-spectrum fungicide, including against some multidrug-resistant strains. Compared with the normal chemical and physical preparation methods, green synthesis has attracted wide attention, because of the pharmaceutical activities of the natural product, [...] Read more.
The silver nanoparticle is a good antibacterial material being used as a broad-spectrum fungicide, including against some multidrug-resistant strains. Compared with the normal chemical and physical preparation methods, green synthesis has attracted wide attention, because of the pharmaceutical activities of the natural product, mild reaction conditions, and environmentally friendly, etc. In this study, the synthesis of silver nanoparticles (Ag NPs) was prepared from Bletilla striata polysaccharide (BSP) and characterized by UV-vis spectroscopy and Dynamic Light Scattering (DLS). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicated the morphology of Ag NPs was subspherical with an average size of 20–35 nm. Bletilla striata polysaccharide not only can be used as a natural reducing agent, but also has good repairing ability. Moreover, the antibacterial experimental results showed its great antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli) and Candida albicans. Full article
(This article belongs to the Special Issue Functional Inorganic Materials for Biomedical Application)
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