Synthesis, Structural Analysis and Biological Activity of Metal Complexes
A special issue of Inorganics (ISSN 2304-6740).
Deadline for manuscript submissions: 31 May 2025 | Viewed by 17
Special Issue Editors
Interests: metal complexes; DNA interactions; protein inhibition; anticancer metallodrugs; crystallography
Interests: metal complexes; DNA interactions; protein inhibition; ROS (reactive oxygen species); anticancer metallodrugs; EPR spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of Inorganics, titled "Synthesis, Structural Analysis and Biological Activity of Metal Complexes", places particular emphasis on the biological applications and therapeutic potential of different metal complexes, both endogenous or exogenous. Based on recent advancements in design and synthesis methodology, researchers are now able to fine-tune metal complexes for specific biological activities, enabling targeted interactions with selected biomolecules such as enzymes, proteins and DNA. These interactions are crucial for developing metal-based therapies, and studies in this Issue highlight significant progress in using metal complexes to fight infections, cancer, inflammatory diseases, viruses and neurodegenerative disorders.
Alongside biological insights, structural analysis plays a vital role in understanding the precise configurations, possible isomers and interactions of these complexes, providing crucial details about metal–ligand bonding and molecular architecture. Mechanistic studies further reveal how metal complexes can trigger biochemical pathways or disrupt biological processes in beneficial ways for therapeutic use. Theoretical simulations can give support to experimental data or screen probable possibilities. Together, these findings demonstrate the potential of metal complexes as powerful tools in medicinal chemistry, offering new solutions to longstanding health challenges while promoting interdisciplinary collaboration between inorganic chemistry and the life sciences.
Prof. Dr. João Honorato de Araujo-Neto
Prof. Dr. Ana Maria Da Costa Ferreira
Guest Editors
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Keywords
- metal complexes
- biological activity
- therapeutic applications
- structural analysis
- metal–biomolecule interactions
- medicinal inorganic chemistry
- anticancer agents
- antimicrobial activity
- antiviruses activity
- neurodegenerative disease management
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