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Inorganics
Special Issues
Metal-Based Antimicrobials
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Metal-Based Antimicrobials

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 13224

Special Issue Editors

Prof. Dr. Miloš I. Djuran

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Guest Editor
1. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, P.O.Box 60, 34000 Kragujevac, Serbia
2. Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia
Interests: coordination chemistry of transition metal ions; structural characterization of transition metal complexes; transition metal complexes as antitumor and antimicrobial agents; platinum(II) and palladium(II) complexes as potential reagents for regioselective hydrolysis of peptides and proteins; interaction of transition metal complexes with biomolecules in correlation to the mechanism of their biological activity
Dr. Jasmina Nikodinović-Runić

E-Mail Website
Guest Editor
Institute of Molecular Genetics and Genetic Engineering (IMGGE), University of Belgrade, 11010 Belgrade, Serbia
Interests: microbial biotechnology; biological polymers; biocatalysis; bioremediation; bioactive molecules; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Dr. Biljana Đ. Glišić

E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia
Interests: medicinal inorganic chemistry; metal complexes; gold complexes; silver complexes; nitrogen-donor ligands; peptides; DNA interactions; protein interactions; antimicrobial agents

Special Issue Information

Dear Colleagues,

Infectious diseases are becoming increasingly difficult to treat, because many microbes have developed resistance to clinically used antimicrobials. Antimicrobial resistance is especially correlated with the presence of biofilms, because in this form, microbes manifest up to one thousand times higher resistance. It is estimated that antimicrobial resistance causes at least 50 thousand deaths each year in Europe and the United States, and that it will cause 10 million deaths worldwide per year by 2050. Therefore, the development of new antimicrobial agents is of paramount importance. Metal complexes might represent a novel class of antimicrobial agents because of their favorable features compared with organic compounds, including enhanced stereochemistry and reactivity, lipophilicity, and different modes of action.

This Special Issue aims to highlight the progress in the field of the synthesis of novel metal complexes as potential antimicrobial agents, and investigation of their interactions with biological targets.  

Prof. Dr. Miloš I. Djuran
Dr. Jasmina Nikodinović-Runić
Dr. Biljana Đ. Glišić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal inorganic chemistry
  • drug discovery and development
  • antimicrobial resistance
  • metal complexes
  • synthesis and structural characterization
  • antimicrobial activity
  • biofilms
  • mechanism of antimicrobial activity
  • interaction with biomolecules
  • structure-activity relationship

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Published Papers (3 papers)

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Research

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17 pages, 3144 KiB  
Article
Zinc(II) Complexes with Dimethyl 2,2′-Bipyridine-4,5-dicarboxylate: Structure, Antimicrobial Activity and DNA/BSA Binding Study
by Tina P. Andrejević, Ivana Aleksic, Jakob Kljun, Bojana V. Pantović, Dusan Milivojevic, Sandra Vojnovic, Iztok Turel, Miloš I. Djuran and Biljana Đ. Glišić
Inorganics 2022, 10(6), 71; https://doi.org/10.3390/inorganics10060071 - 26 May 2022
Cited by 6 | Viewed by 2740
Abstract
Two zinc(II) complexes with dimethyl 2,2′-bipyridine-4,5-dicarboxylate (py-2py) of the general formula [Zn(py-2py)X2], X = Cl− (1) and Br− (2) were synthesized and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. Complexes [...] Read more.
Two zinc(II) complexes with dimethyl 2,2′-bipyridine-4,5-dicarboxylate (py-2py) of the general formula [Zn(py-2py)X2], X = Cl− (1) and Br− (2) were synthesized and characterized by NMR, IR and UV-Vis spectroscopy and single-crystal X-ray diffraction analysis. Complexes 1 and 2 are isostructural and adopt a slightly distorted tetrahedral geometry with values of tetrahedral indices τ4 and τ’4 in the range of 0.80–0.85. The complexes were evaluated for their in vitro antimicrobial activity against two bacterial (Pseudomonas aeruginosa and Staphylococcus aureus) and two fungal strains (Candida albicans and Candida parapsilosis), while their cytotoxicity was tested on the normal human lung fibroblast cell line (MRC-5) and the model organism Caenorhabditis elegans. Complex 1 showed moderate activity against both Candida strains. However, this complex was twofold more cytotoxic compared to complex 2. The complexes tested had no effect on the survival rate of C. elegans. Complex 2 showed the ability to inhibit filamentation of C. albicans, while complex 1 was more effective than complex 2 in inhibiting biofilm formation. The interactions of complexes 1 and 2 with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) were studied to evaluate their binding affinity toward these biomolecules. Full article
(This article belongs to the Special Issue Metal-Based Antimicrobials)
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Review

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15 pages, 2044 KiB  
Review
Strike a Balance: Between Metals and Non-Metals, Metalloids as a Source of Anti-Infective Agents
by Tiziano Marzo and Diego La Mendola
Inorganics 2021, 9(6), 46; https://doi.org/10.3390/inorganics9060046 - 4 Jun 2021
Cited by 14 | Viewed by 4413
Abstract
Most of the commercially available anti-infective agents are organic molecules. In fact, though, during the pioneering times of modern medicine, at the beginning of the 20th century, several inorganic compounds of transition metals were used for medicinal application, to date, only a small [...] Read more.
Most of the commercially available anti-infective agents are organic molecules. In fact, though, during the pioneering times of modern medicine, at the beginning of the 20th century, several inorganic compounds of transition metals were used for medicinal application, to date, only a small number of inorganic drugs are used in clinical practice. Beyond the transition metals, metalloids—or semimetals—offer a rich chemistry in between that of metallic and non-metallic elements, and accordingly, peculiar features for their exploitation in medicinal chemistry. A few important examples of metalloid-based drugs currently used for the treatment of various diseases do exist. However, the use of this group of elements could be further expanded on the basis of their current applications and the clinical trials they entered. Considering that metalloids offer the opportunity to expand the “chemical-space” for developing novel anti-infective drugs and protocols, in this paper, we briefly recapitulate and discuss the current applications of B-, Si-, As-, Sb- and Te-based anti-infective drugs. Full article
(This article belongs to the Special Issue Metal-Based Antimicrobials)
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Other

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12 pages, 1899 KiB  
Project Report
Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices
by Simonida Lj. Tomić and Jovana S. Vuković
Inorganics 2022, 10(3), 38; https://doi.org/10.3390/inorganics10030038 - 18 Mar 2022
Cited by 12 | Viewed by 3888
Abstract
The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve human health. The use of metals in various forms as antimicrobial therapeutics has [...] Read more.
The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve human health. The use of metals in various forms as antimicrobial therapeutics has been known since ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections. Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility, and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with silver (Ag+), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as antimicrobial therapeutics and suitable biomaterials for medical applications. Full article
(This article belongs to the Special Issue Metal-Based Antimicrobials)
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