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Clinical Applications of Cardiovascular Computed Tomography (CT)
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Clinical Applications of Cardiovascular Computed Tomography (CT)

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Imaging".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 6094

Special Issue Editor

Dr. David C. Rotzinger

E-Mail Website
Guest Editor
Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
Interests: CT; CT angiography; spectral CT; coronary artery disease; pulmonary embolism; cardiac imaging

Special Issue Information

Dear Colleagues,

In its three decades of existence, cardiovascular CT has profoundly disrupted patient assessment and has established itself as one of the most recommended tests to guide patient management. This success was attributed to CT’s unique ability to depict morphology with incredible detail, but also physiology and function during the same examination. Despite tremendous technological developments that have helped improve imaging speed, diagnostic accuracy, and patient safety, CT is constantly reinventing itself with new applications arising regularly. Open questions remain regarding the prevention and treatment of cardiovascular disease, primarily based on the need to identify high-risk patients before they experience clinical symptoms and to guide invasive therapy. At the same time, the worldwide use of CT is still on the rise, raising safety concerns. In younger patients, the main issue is the exposure to ionizing radiation, while for the elderly with impaired renal function, the principal concern may be contrast-associated acute kidney injury.

This special issue aims to provide new insights into the clinical benefits of cardiovascular CT, including novel technology (spectral imaging, reconstruction algorithms, quantitative or functional imaging, artificial intelligence), advances in disease diagnosis and prevention, and emerging techniques (fractional flow reserve, perfusion imaging, pericoronary fat attenuation).

Dr. David C. Rotzinger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • computed tomography angiography
  • cardiovascular imaging
  • contrast media
  • spectral computed tomography
  • quantitative imaging
  • coronary artery disease
  • aortic disease
  • pulmonary embolism
  • structural heart disease

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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13 pages, 1763 KiB  
Article
Thrombus Imaging Characteristics to Predict Early Recanalization in Anterior Circulation Large Vessel Occlusion Stroke
by Nerea Arrarte Terreros, Jeffrey Stolp, Agnetha A. E. Bruggeman, Isabella S. J. Swijnenburg, Ricardo R. Lopes, Laura C. C. van Meenen, Adrien E. D. Groot, Manon Kappelhof, Jonathan M. Coutinho, Yvo B. W. E. M. Roos, Bart J. Emmer, Ludo F. M. Beenen, Diederik W. J. Dippel, Wim H. van Zwam, Ed van Bavel, Henk A. Marquering and Charles B. L. M. Majoie
J. Cardiovasc. Dev. Dis. 2024, 11(4), 107; https://doi.org/10.3390/jcdd11040107 - 29 Mar 2024
Viewed by 1478
Abstract
The early management of transferred patients with a large vessel occlusion (LVO) stroke could be improved by identifying patients who are likely to recanalize early. We aim to predict early recanalization based on patient clinical and thrombus imaging characteristics. We included 81 transferred [...] Read more.
The early management of transferred patients with a large vessel occlusion (LVO) stroke could be improved by identifying patients who are likely to recanalize early. We aim to predict early recanalization based on patient clinical and thrombus imaging characteristics. We included 81 transferred anterior-circulation LVO patients with an early recanalization, defined as the resolution of the LVO or the migration to a distal location not reachable with endovascular treatment upon repeated radiological imaging. We compared their clinical and imaging characteristics with all (322) transferred patients with a persistent LVO in the MR CLEAN Registry. We measured distance from carotid terminus to thrombus (DT), thrombus length, density, and perviousness on baseline CT images. We built logistic regression models to predict early recanalization. We validated the predictive ability by computing the median area-under-the-curve (AUC) of the receiver operating characteristics curve for 100 5-fold cross-validations. The administration of intravenous thrombolysis (IVT), longer transfer times, more distal occlusions, and shorter, pervious, less dense thrombi were characteristic of early recanalization. After backward elimination, IVT administration, DT and thrombus density remained in the multivariable model, with an AUC of 0.77 (IQR 0.72–0.83). Baseline thrombus imaging characteristics are valuable in predicting early recanalization and can potentially be used to optimize repeated imaging workflow. Full article
(This article belongs to the Special Issue Clinical Applications of Cardiovascular Computed Tomography (CT))
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13 pages, 2204 KiB  
Article
A Pilot Study on the Role of Computed Tomography in the Management of Patients with Coronary Artery Anomalies in Romania
by Adriana Sorina Capisizu, Dragos Cuzino and Silviu Marcel Stanciu
J. Cardiovasc. Dev. Dis. 2023, 10(4), 170; https://doi.org/10.3390/jcdd10040170 - 15 Apr 2023
Cited by 1 | Viewed by 1982
Abstract
Coronary artery anomalies may occur during embryogenesis and can lead to changes in the vascularization of the heart, possible ischemia, and an increased risk of sudden death. A retrospective study was conducted with the aim of assessing the prevalence of coronary anomalies in [...] Read more.
Coronary artery anomalies may occur during embryogenesis and can lead to changes in the vascularization of the heart, possible ischemia, and an increased risk of sudden death. A retrospective study was conducted with the aim of assessing the prevalence of coronary anomalies in a Romanian sample of patients, investigated with computed tomography angiography for coronary artery disease. The objectives of the study were to identify the anomalies of the coronary arteries and to conduct an anatomical classification according to Angelini. The study also consisted of evaluations regarding coronary artery calcification in the sample of patients by the Agatston calcium score and assessments regarding the presence of cardiac symptoms and their association with coronary abnormalities. The results showed a prevalence of coronary anomalies of 8.7%, of which 3.8% were origin and course anomalies and 4.9% were coronary anomalies with intramuscular bridging of the left anterior descending artery. Recommendations for practice include the widespread use of coronary computed tomography angiography for the diagnosis of coronary artery anomalies and coronary artery disease in larger patient groups and encouraging this investigation across the country. Full article
(This article belongs to the Special Issue Clinical Applications of Cardiovascular Computed Tomography (CT))
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Other

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9 pages, 876 KiB  
Study Protocol
Investigating the Influence of High-Speed Gantry Rotation in Cardiac CT on Motion Artifacts in Aortic Stenosis Patients Not Premedicated with β-Blockers: The FAST-CCT Randomized Trial Protocol
by Guillaume Fahrni, Giuseppe Gullo, Aisha Touray, Stéphane Fournier, Anne-Marie Jouannic, Henri Lu, Damien Racine, Olivier Muller, Chiara Pozzessere, Salah D. Qanadli and David C. Rotzinger
J. Cardiovasc. Dev. Dis. 2023, 10(10), 424; https://doi.org/10.3390/jcdd10100424 - 12 Oct 2023
Cited by 2 | Viewed by 1926
Abstract
Background: Coronary CT angiography (CCTA) is increasingly used as a non-invasive tool to assess coronary artery disease (CAD). However, CCTA is subject to motion artifacts, potentially limiting its clinical utility. Despite faster (0.35 and 0.28 s/rot) gantry rotation times, low (60–65 bpm) heartbeat [...] Read more.
Background: Coronary CT angiography (CCTA) is increasingly used as a non-invasive tool to assess coronary artery disease (CAD). However, CCTA is subject to motion artifacts, potentially limiting its clinical utility. Despite faster (0.35 and 0.28 s/rot) gantry rotation times, low (60–65 bpm) heartbeat is recommended, and the use of β-blockers is often needed. Technological advancements have resulted in the development of faster rotation speeds (0.23 s/rot). However, their added value in patients not premedicated with β-blockers remains unclear. This prospective single-center, two-arm, randomized, controlled trial aims to assess the influence of fast rotation on coronary motion artifacts, diagnostic accuracy of CCTA for CAD, and patient safety. Methods: We will randomize a total of 142 patients aged ≥ 50 scheduled for an aortic stenosis work-up to receive CCTA with either a fast (0.23) or standard (0.28 s/rot) gantry speed. Primary outcome: rate of CCTAs with coronary motion artifacts hindering interpretation. Secondary outcomes: assessable coronary segments rate, diagnostic accuracy against invasive coronary angiography (ICA), motion artifact magnitude per segment, contrast-to-noise ratio (CNR), and patient ionizing radiation dose. The local ethics committee has approved the protocol. Potential significance: FAST-CCT may improve motion artifact reduction and diagnosis quality, thus eliminating the need for rate control and β-blocker administration. Clinicaltrials.gov identifier: NCT05709652. Full article
(This article belongs to the Special Issue Clinical Applications of Cardiovascular Computed Tomography (CT))
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Name： Arnaud Van Linden
Affiliation：Universitätsklinikum Frankfurtdisabled, Frankfurt am Main, Germany
Title: Coronary plaque quantification using a new CT imaging software - a feasibility study

Name：Hong Wang
Affiliation：Pediatric department of shengjing hospital, China Medical University, 110004, shenyang, China
Title: Pending

Name：David C. Rotzinger
Affiliation：Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
Title: Pending

Name：Anna Giulia Pavon
Affiliation：Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland
Title: Pending

Name：Andrzej Wysocki, Michał Fułek, Piotr Macek, Monika Michałek-Zrąbkowska, Krzysztof Kraik, Małgorzata Poręba, Katarzyna Fułek, Helena Martynowicz, Grzegorz Mazur, Paweł Gać and Rafał Poręba
Affiliation：Wroclaw University of Health and Sport Sciences, 4th Military Hospital in Wroclaw, Wroclaw Medical University, Poland
Title: The ultrasound assessment of carotid plaque score as an indicator of occurrence and severity of atheroscleric changes in the coronary artery in patients with arterial hypertension

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