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Clinical Diagnosis and Treatment of Cerebrovascular Diseases
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Clinical Diagnosis and Treatment of Cerebrovascular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 3330

Special Issue Editor

Dr. Björn Sommer

E-Mail Website
Guest Editor
Department of Neurosurgery, University Hospital Augsburg, 86156 Augsburg, Germany
Interests: brain imaging; cerebrovascular disease; neuro-oncology; ultrasound; epilepsy surgery

Special Issue Information

Dear Colleagues,

According to the WHO, 32% of all global deaths are caused by cerebrovascular diseases. Thus, a reduction in the social and economic burden of these diseases is one of the major goals of medicine, particularly for all disciplines that focus on the diagnosis and treatment of the underlying causes. Both the arterial side of the extra- and intracranial blood vessels and the venous system are coming more and more into focus for scientific research in this field.

This Special Issue is dedicated to current research and novel insights on pathologies of the cerebrovascular system ranging from atherosclerosis to thromboembolism, stenosis, arterio-venous malformations, cavernomas and cerebral aneurysms. Emphasis is placed on novel diagnostic tools and treatment approaches including prevention and management of secondary complications such as cerebral vasospasm, delayed cerebral ischemia, hyperperfusion syndrome or brain edema. Thus, the aim of this Special Issue is to provide the reader with current developments and new insights.

Dr. Björn Sommer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • intracranial stenosis
  • aneurysm
  • malformation
  • occlusion
  • therapy
  • detection

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Published Papers (2 papers)

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Research

11 pages, 3822 KiB  
Article
Endovascular Embolization of Intracranial Aneurysms Using Target Tetra Detachable Coils: Angiographic and Clinical Results from a Single Center
by Wook Kim, Tae Keun Jee, Je Young Yeon, Keon Ha Kim, Jong-Soo Kim and Pyoung Jeon
J. Clin. Med. 2024, 13(16), 4940; https://doi.org/10.3390/jcm13164940 - 21 Aug 2024
Viewed by 1134
Abstract
Background/Objectives: Target tetra detachable coils (TTDCs) aid in achieving effective framing during the coil embolization of small intracranial aneurysms by maintaining a tetrahedral conformation within the aneurysm sac. We aimed to report the initial experience of patients treated for intracranial aneurysms using [...] Read more.
Background/Objectives: Target tetra detachable coils (TTDCs) aid in achieving effective framing during the coil embolization of small intracranial aneurysms by maintaining a tetrahedral conformation within the aneurysm sac. We aimed to report the initial experience of patients treated for intracranial aneurysms using TTDCs, with a specific focus on efficacy and safety. Methods: We retrospectively reviewed the medical records of 41 patients who underwent the coil embolization of intracranial aneurysms sized ≤10 mm with TTDCs between April and May 2023. Post-procedural angiographic and clinical results were reviewed. Results: Of the 46 aneurysms (45 unruptured and 1 ruptured), 33 (71.7%) were treated with the stent-assisted technique and 13 (28.3%) using the simple coil embolization technique. Post-procedural angiography showed complete occlusion in 41 aneurysms (89.1%), neck remnants in 1 (2.2%), and residual aneurysms in 4 (8.7%). The mean packing density was 34.7% (19.3–46.8%), with TTDC coil length comprising a mean of 88.5% of the total coil length. No major device- or procedure-related complications were observed. During the follow-up, 40 aneurysms (93.0%) demonstrated complete occlusion, while neck remnants were observed in 1 (2.3%), and residual aneurysms in 2 (4.7%). No cases of recanalization were observed. Conclusions: The TTDC is a safe and effective device for the endovascular treatment of intracranial aneurysms. Follow-up studies are required to establish long-term results. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Treatment of Cerebrovascular Diseases)
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12 pages, 1608 KiB  
Article
Agreement between CT-Angiography and Digital Subtraction Angiography in Predicting Angiographic Vasospasm in Patients with Subarachnoid Hemorrhage
by Miriam M. Moser, Leon Gramss, Wolfgang Marik, Michael Weber, Dorian Hirschmann, Wei-Te Wang, Philippe Dodier, Gregor Kasprian, Gerhard Bavinzski, Karl Rössler and Arthur Hosmann
J. Clin. Med. 2024, 13(13), 3743; https://doi.org/10.3390/jcm13133743 - 26 Jun 2024
Viewed by 1788
Abstract
Background/Objectives: Digital subtraction angiography (DSA) is the gold standard in the diagnosis of cerebral vasospasm, frequently observed after subarachnoid hemorrhage (SAH). However, less-invasive methods, such as computed tomography angiography (CTA), may be equally accurate. To further clarify comparability, this study evaluated the reliability [...] Read more.
Background/Objectives: Digital subtraction angiography (DSA) is the gold standard in the diagnosis of cerebral vasospasm, frequently observed after subarachnoid hemorrhage (SAH). However, less-invasive methods, such as computed tomography angiography (CTA), may be equally accurate. To further clarify comparability, this study evaluated the reliability of CTA in detecting cerebral vasospasm. Methods: This retrospective study included 51 patients with SAH who underwent both CTA and DSA within 24 h. The smallest diameter of the proximal cerebral arterial segments was measured in both modalities at admission and during the vasospasm period. The mean difference in diameter, the intraclass correlation coefficient (ICC) of CTA and DSA, the difference in grade of vasospasm and sensitivity, the specificity and the positive predictive value (PPV) for CTA were calculated. Results: A total of 872 arterial segments were investigated. At time of admission, arterial diameters were significantly smaller on CTA compared to DSA in all segments (−0.26 ± 0.12 mm; p < 0.05). At time of suspected vasospasm (day 9 ± 5), these differences remained significant only for the M1 segment (−0.18 ± 0.37 mm, p = 0.02), the P1 segment (−0.13 ± 0.24 mm, p = 0.04) and the basilar artery (−0.20 ± 0.37 mm, p = 0.0.04). The ICC between CTA and DSA was good (0.5–0.8). The sensitivity of CTA for predicting angiographic vasospasm was 99%, the specificity was 50% and the PPV was 92%. Conclusions: Arterial diameters measured on CTA may underestimate the arterial caliber observed in DSA; however, these absolute differences were minor. Importantly, vessel diameter alone does not fully reflect malperfusion, requiring additional imaging techniques such as CT perfusion. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Treatment of Cerebrovascular Diseases)
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