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Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO)
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Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO)

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".

Deadline for manuscript submissions: 9 February 2025 | Viewed by 3945

Special Issue Editors

Dr. Sung-Min Cho

E-Mail Website
Guest Editor
Division of Neurosciences Critical Care, Department of Neurology, Surgery, Anaesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA
Interests: extracorporeal membrane oxygenation; stroke; cardiopulmonary resuscitation; brain injury; intracranial hemorrhage
Special Issues, Collections and Topics in MDPI journals
Dr. Akram Zaaqoq

E-Mail Website
Guest Editor
Department of Anesthesiology, Division of Critical Care, University of Virginia, Charlottesville, VA 22903, USA
Interests: critical care medicine; intensive care medicine; sepsis; resuscitation; cardiopulmonary resuscitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of extracorporeal membrane oxygenation (ECMO) has dramatically increased in the last decade. Veno-Arterial (V-A) ECMO is the most common strategy for the rescue of refractory cardiac failure, and Veno-Venous (VV) ECMO is employed for refractory respiratory failure. Innovative and new therapies, monitoring strategies, and clinical evidence/research are being continually developed in the field of ECMO. As advances in therapeutics, technology, and management strategy have improved outcomes in the field of ECMO, improving adverse events such as on-ECMO complications and organ dysfunction is of the utmost importance in patients with ECMO support. Therefore, it is critical that ECMO providers are up to date on these new developments and how they are related to outcomes to provide appropriate critical care for our patients. In this Special Issue, we welcome authors to submit papers on the recent advances in translational and clinical research in V-A and V-V ECMO.

Dr. Sung-Min Cho
Dr. Akram Zaaqoq
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracorporeal membrane oxygenation
  • ECMO
  • multi-organ failure
  • outcomes
  • V-A ECMO
  • ECPR
  • V-V ECMO
  • translational research
  • clinical research

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Published Papers (2 papers)

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Research

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15 pages, 1287 KiB  
Article
Neuron-Specific Enolase as a Predictor of Neurologic Outcomes in Extracorporeal Cardiopulmonary Resuscitation Patients
by Yong Ho Jeong, Suk Kyung Lim, Yongil Cho, Yun Jin Kim, Hyo Jun Jang, Yang Hyun Cho, Yonghoon Shin, Jae Seung Jung, Jin Kook Kang, Sung-Min Cho and Jun Ho Lee
J. Clin. Med. 2024, 13(14), 4135; https://doi.org/10.3390/jcm13144135 - 15 Jul 2024
Cited by 1 | Viewed by 1049
Abstract
Background: Neuron-specific enolase (NSE) has traditionally been used as a biomarker to predict neurologic outcomes after cardiac arrest. This study aimed to evaluate the utility of NSE in predicting neurologic outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). Methods: This observational cohort study [...] Read more.
Background: Neuron-specific enolase (NSE) has traditionally been used as a biomarker to predict neurologic outcomes after cardiac arrest. This study aimed to evaluate the utility of NSE in predicting neurologic outcomes in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR). Methods: This observational cohort study included 47 consecutive adult ECPR patients (median age, 59.0 years; 74.5% males) treated between January 2018 and December 2021 at a tertiary extracorporeal life support center. The primary outcome was a poor neurologic outcome, defined as a Cerebral Performance Category score of 3–5 at hospital discharge. Results: Twelve (25.5%) patients had abnormal findings on computed tomography of the brain. A poor neurologic outcome was demonstrated in 22 (46.8%) patients. The NSE level at 72 h after ECPR showed the best prediction power for a poor neurologic outcome compared with NSE at 24 and 48 h. A cutoff value exceeding 61.9 μg/L for NSE at 72 h yielded an area under the curve (AUC) of 0.791 for predicting poor neurologic outcomes and exceeding 62.1 μg/L with an AUC of 0.838 for 30-day mortality. Conclusions: NSE levels at 72 h after ECPR appear to be a reliable biomarker for predicting poor neurologic outcomes and 30-day mortality in ECPR patients. Full article
(This article belongs to the Special Issue Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO))
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Review

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15 pages, 2787 KiB  
Review
Echocardiographic and Point-of-Care Ultrasonography (POCUS) Guidance in the Management of the ECMO Patient
by Stephanie Cha and Megan P. Kostibas
J. Clin. Med. 2024, 13(9), 2630; https://doi.org/10.3390/jcm13092630 - 30 Apr 2024
Viewed by 2230
Abstract
Veno-arterial (V-A) and Veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) support is increasingly utilized for acute cardiogenic shock and/or respiratory failure. Echocardiography and point-of-care ultrasonography (POCUS) play a critical role in the selection and management of these critically ill patients, however, there are limited [...] Read more.
Veno-arterial (V-A) and Veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) support is increasingly utilized for acute cardiogenic shock and/or respiratory failure. Echocardiography and point-of-care ultrasonography (POCUS) play a critical role in the selection and management of these critically ill patients, however, there are limited guidelines regarding their application. This comprehensive review describes current and potential application of echocardiography and POCUS for pre-ECMO assessment and patient selection, cannulation guidance with emphasis on dual-lumen configurations, diagnosis of ECMO complications and trouble-shooting of cannula malposition, diagnosis of common cardiac or pulmonary pathologies, and assessment of ECMO weaning appropriateness including identification of the aortic mixing point in V-A ECMO. Full article
(This article belongs to the Special Issue Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO))
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