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Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second...
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Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 14 April 2025 | Viewed by 2860

Special Issue Editor

Prof. Dr. Takeshi Iwase

E-Mail Website
Guest Editor
Department of Ophthalmology, Akita University Graduate School of Medicine, Akita 010-8543, Japan
Interests: retinal diseases; vitreoretinal diseases; vitrectomy; vitreoretinal surgery; diabetic retinopathy; retinal vein occlusion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to invite you to contribute to this Special Issue, entitled "Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second Edition". For more details on the first volume, in which we published five papers, please visit https://www.mdpi.com/journal/jcm/special_issues/K7J958P42Q.

In recent years, the management of retinal and choroidal diseases has undergone major advances in diagnosis and treatment. In the area of diagnosis, the past two decades have seen significant advances in optical coherence tomography (OCT) as well as OCT angiography and color scanning laser ophthalmoscopy, which have become popular worldwide. Thus, multimodal imaging has improved the accuracy of diagnosis and the understanding of pathological conditions. The development of testing equipment also means an increase in the number of images of healthy and diseased eyes.

Treatments for diseases have also evolved dramatically. No one would dispute that the first of these are anti-vascular endothelial growth factor (VEGF) drugs. Anti-VEGF drugs have become a mainstay in the treatment of retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and macular edema, and have greatly expanded the potential of drug therapy for these diseases.

This Special Issue invites a wide range of research related to ophthalmic diagnosis and management. Our aim is for this Special Issue to be of help in the diagnosis and management of vitreo-retinal disorders and to assist in your future research.

Prof. Dr. Takeshi Iwase
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitreo-retinal disorders
  • optical coherence tomography (OCT)
  • OCT angiography
  • anti-VEGF therapy
  • image analysis
  • vitrectomy

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Published Papers (3 papers)

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Research

11 pages, 11652 KiB  
Article
Optical Attenuation Coefficient-Based En Face Optical Coherence Tomography Imaging for the Reliable Assessment of the Ellipsoid Zone
by Hiroaki Sakai, Riku Kuji, Yoshikiyo Moriguchi, Shoko Yamashita, Ayako Takamori, Masato Tamura, Toshihiro Mino, Masahiro Akiba and Hiroshi Enaida
J. Clin. Med. 2024, 13(23), 7140; https://doi.org/10.3390/jcm13237140 - 25 Nov 2024
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Abstract
Objective: This study used optical attenuation coefficient (OAC)-based optical coherence tomography (OCT) en face images to assess the ellipsoid zone (EZ) in the foveal region. Methods: This retrospective, observational, cross-sectional study of 41 healthy volunteers and 34 patients with retinal diseases included imaging [...] Read more.
Objective: This study used optical attenuation coefficient (OAC)-based optical coherence tomography (OCT) en face images to assess the ellipsoid zone (EZ) in the foveal region. Methods: This retrospective, observational, cross-sectional study of 41 healthy volunteers and 34 patients with retinal diseases included imaging data acquired using a prototype swept-source OCT system. EZ en face images were generated from OCT raster scan volumes based on OAC, followed by denoising and binarization to quantify the percentage of EZ structural normality or abnormality relative to the total imaging area. We evaluated the reliability of the OAC-based method compared with the OCT signal intensity-based method in healthy and diseased eyes. In addition, the validated program was applied to patients with various retinal conditions. Results: The estimated normal EZ area in healthy eyes was 96.2 ± 5.6% using the OAC-based method versus 89.3 ± 18.8% for the intensity-based method. The OAC-based method effectively mitigated various artifacts caused by retinal blood vessels and other factors in both healthy and diseased eyes. In a pilot study involving six diseased eyes, the area exhibiting EZ structural abnormalities was 27.5–99.6%. Conclusions: The OAC-based EZ assessment robustly suppressed image artifacts and reliably characterized structural abnormalities in the EZ from OCT volumes. Full article
(This article belongs to the Special Issue Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second Edition)
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13 pages, 980 KiB  
Article
Survey on Findings and Utilization of Preoperative Chest Radiography in Ophthalmic Surgery
by Yohei Kuroki, Ayako Takamori, Koichiro Takahashi, Soichiro Yamamoto, Noriko Yoshida and Hiroshi Enaida
J. Clin. Med. 2024, 13(13), 3909; https://doi.org/10.3390/jcm13133909 - 3 Jul 2024
Viewed by 1112
Abstract
Objective: The objective of this paper is to reconsider the significance of preoperative chest radiography (CXR) before ophthalmic surgery through investigation of imaging findings and usage status. Methods: This retrospective observational clinical study involved 1616 patients who underwent ophthalmic surgery at [...] Read more.
Objective: The objective of this paper is to reconsider the significance of preoperative chest radiography (CXR) before ophthalmic surgery through investigation of imaging findings and usage status. Methods: This retrospective observational clinical study involved 1616 patients who underwent ophthalmic surgery at Saga University Hospital from 1 January 2019 to 31 December 2020. The patients’ radiology reports were obtained from the electronic medical records, and their CXR findings, therapeutic interventions, and progress were investigated. Results: Among all patients, 539 (33.4%) had abnormal preoperative CXR findings. Of these patients, 74 (4.6%) had newly identified abnormal findings. In both patient groups, approximately 70% of patients with abnormal findings were aged ≥70 years, and interstitial shadows were the most common finding. Among all patients with abnormal findings, three (0.19%) received preoperative therapeutic interventions, and all surgeries were performed safely. Forty-three patients with abnormal findings were referred to our hospital or other hospitals for further investigation and treatment postoperatively. Among those patients, eight (0.5%) had primary lung cancer, seven underwent surgery, and one received chemoradiation. The other patients were also followed up and received appropriate therapeutic interventions. Conclusions: Before ophthalmic surgery, few patients required actual therapeutic interventions based on their CXR results. However, many abnormal findings were revealed in elderly patients, including some serious diseases. Furthermore, research has suggested that appropriate therapeutic intervention after ophthalmologic surgery may reduce the risk of a poor life prognosis. This study clearly shows that preoperative CXR is not only useful for perioperative systemic management but also ultimately benefits patients. It is also considered particularly meaningful for patients aged ≥70 years. Full article
(This article belongs to the Special Issue Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second Edition)
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13 pages, 9923 KiB  
Article
Atypical Presentations of Hydroxychloroquine Retinopathy: A Case Series Study
by Jung Min Lee, Hyeon Yoon Kwon and Seong Joon Ahn
J. Clin. Med. 2024, 13(12), 3411; https://doi.org/10.3390/jcm13123411 - 11 Jun 2024
Cited by 1 | Viewed by 975
Abstract
Background/Objective: Hydroxychloroquine retinopathy, traditionally characterized by parafoveal or pericentral outer retinal damage, is explored for atypical presentations in Asian patients. This challenges conventional beliefs regarding onset, retinopathy pattern, and associated visual field defects. Methods: Ninety-five patients diagnosed with hydroxychloroquine retinopathy at Hanyang University [...] Read more.
Background/Objective: Hydroxychloroquine retinopathy, traditionally characterized by parafoveal or pericentral outer retinal damage, is explored for atypical presentations in Asian patients. This challenges conventional beliefs regarding onset, retinopathy pattern, and associated visual field defects. Methods: Ninety-five patients diagnosed with hydroxychloroquine retinopathy at Hanyang University Hospital underwent screening from January 2010 to December 2023. Swept-source optical coherence tomography (SS-OCT), ultra-widefield fundus autofluorescence (UWF-FAF), and automated visual fields (VF) were employed for detailed structural and functional evaluations. Multifocal electroretinography was performed in selected cases requiring additional objective evidence of retinal toxicity. Results: Among 95 patients, 14 (14.7%) exhibited atypical presentations, including very early onset (n = 1), (far) peripheral-dominant damages (n = 4), perivascular involvement (n = 1), bitemporal hemianopsia due to nasal extensive lesions (n = 1), unilateral involvement (n = 2), and asymmetric involvement in retinopathy pattern or severity between the eyes (n = 7). These findings underscore the importance of utilizing expanded imaging techniques, such as ultra-widefield FAF imaging, to identify atypical presentations of retinal involvement. Conclusions: Screening physicians should consider these atypical presentations to ensure timely diagnosis and appropriate management in patients undergoing hydroxychloroquine treatment. Full article
(This article belongs to the Special Issue Latest Advances in the Diagnosis and Management of Vitreo-Retinal Disorders—Second Edition)
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