Challenges in Pediatrics Liver and Nephrology Diseases

Dear Colleagues,

The field of pediatric liver and nephrology has expanded over the past decades as research has progressed. Both the liver and kidneys are key organs for homeostasis and metabolism regulation in the body, with a multifaceted involvement in several conditions.

In parallel with the worldwide obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease in children. It is now clear that NAFLD is not only a risk factor for liver failure and liver cancer, but is also associated with a range of extrahepatic outcomes, as highlighted by the new nomenclature of metabolic (dysfunction)-associated fatty liver disease (MAFLD). Noteworthy is recent evidence that supports a pathogenic link between fatty liver and renal dysfunction since childhood.

On the other hand, pediatric nephrology is rapidly evolving. Among the wide spectrum of renal diseases in children, fundamental questions also remain regarding the assessment and management of children with renal and urinary tract diseases. Impaired kidney function leading to chronic kidney disease is a major clinical problem in children/adolescents due to its clinically relevant prognostic implications.

In addition to conventional management approaches, more recent research efforts have focused on novel therapeutic strategies (e.g., omics, etc.) that might significantly change the landscape of several liver and renal diseases in childhood.

We invite researchers to contribute original research articles, as well as review articles, that will inspire us to continue our efforts to improve our understanding of this challenging field in diagnosis and treatment. As the title suggests, we encourage articles that describe new developments or provide unconventional or inspiring contributions.

Dr. Anna Di Sessa
Guest Editor

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• pediatric
• liver disease
• nephrology disease
• renal and urinary tract diseases
• nonalcoholic fatty liver disease (NAFLD)
• metabolic syndrome
• liver transplantation
• metabolic (dysfunction) associated fatty liver disease (MAFLD)
• omics
• biomarkers
• early diagnosis
• diagnosis
• treatment
• challenges