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Diabetes Prevention and Intervention

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".

Deadline for manuscript submissions: closed (5 June 2024) | Viewed by 4052

Special Issue Editor


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Guest Editor
1. Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 81100 Naples, Italy
2. ASL Avellino, 83100 Avellino, Italy
3. Casa di Cura Montevergine, 83013 Mercogliano, AV, Italy
Interests: diabetes prevention; frail elderly; hypertensive; diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diabetes mellitus (DM) increases the risk of cardiovascular complications and is one of the main determinants of adverse outcomes, including death, re-hospitalization, and functional decline (cognitive and physical), particularly in older adults. Therefore, it is important to achieve glycemic control to avoid complications. Furthermore, since endothelial dysfunction is common in DM, patients should be carefully monitored to prevent micro- and macrovascular complications.

This Special Issue aims to summarize lifestyle and pharmacological interventions that could improve DM patients’ quality of life. Intriguingly, hyperglycemia (irrespective of DM), insulin resistance, and pre-diabetes may be considered specific targets to reduce the risk of adverse events.

Dr. Pasquale Mone
Guest Editor

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Keywords

  • type 2 diabetes mellitus
  • pre-diabetes
  • insulin resistance
  • cardiovascular complications
  • cognitive impairment
  • physical activity
  • frailty
  • endothelial dysfunction

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Published Papers (2 papers)

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Research

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15 pages, 913 KiB  
Article
Sociodemographic and Clinical Determinants on Health-Related Quality of Life in Emerging Andalusian Adults with Type 1 Diabetes: A Cross-Sectional Study
by María-Ángeles Núñez-Baila, Anjhara Gómez-Aragón and José Rafael González-López
J. Clin. Med. 2024, 13(1), 240; https://doi.org/10.3390/jcm13010240 - 31 Dec 2023
Cited by 1 | Viewed by 1595
Abstract
(1) Background: Having type 1 diabetes during emerging adulthood can impact quality of life due to the challenge of balancing optimal glycemic blood levels with a period of transition and exploration. The purpose of this study was to characterize the quality of life [...] Read more.
(1) Background: Having type 1 diabetes during emerging adulthood can impact quality of life due to the challenge of balancing optimal glycemic blood levels with a period of transition and exploration. The purpose of this study was to characterize the quality of life of emerging adults aged 18 to 29 years with type 1 diabetes and to determine the associations between dimensions of Health-Related Quality of Life in type 1 diabetes and sociodemographic and diabetes-related variables. (2) Methods: This cross-sectional descriptive study was conducted in Andalusia, Spain, from October 2021 to July 2022. A total of 362 emerging adults with type 1 diabetes (67.4% women, mean age 22.8 ± 3.4 years) participated. Data were gathered via sociodemographic information form and the ViDa1 scale. Statistical evaluations, encompassing descriptive analyses, t-tests, ANOVA, Pearson correlations, and logistic regression, were conducted using SPSSv26, adhering to STROBE guidelines. (3) Results: Among the participants, 52.1% have a glycosylated hemoglobin level over 7%. Interference with Life is correlated with sex, age, and age at diagnosis, with age being the only predictor. Self-Care is correlated with and predicted by glycosylated hemoglobin levels. Well-being is correlated with and predicted by sex, Body Mass Index, and glycosylated hemoglobin levels. Concern about the Condition is correlated with and predicted by sex and glycosylated hemoglobin levels. (4) Conclusions: Despite concerns about their disease, participants generally maintain optimal levels of Health-Related Quality of Life in type 1 diabetes. Predictive factors for Health-Related Quality of Life in type 1 diabetes in this group include sex, age, Body Mass Index, and glycosylated hemoglobin. Full article
(This article belongs to the Special Issue Diabetes Prevention and Intervention)
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Review

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15 pages, 312 KiB  
Review
Mechanisms of Diabetic Nephropathy Not Mediated by Hyperglycemia
by Davide Viggiano
J. Clin. Med. 2023, 12(21), 6848; https://doi.org/10.3390/jcm12216848 - 30 Oct 2023
Cited by 3 | Viewed by 1838
Abstract
Diabetes mellitus (DM) is characterized by the appearance of progressive kidney damage, which may progress to end-stage kidney disease. The control of hyperglycemia is usually not sufficient to halt this progression. The kidney damage is quantitatively and qualitatively different in the two forms [...] Read more.
Diabetes mellitus (DM) is characterized by the appearance of progressive kidney damage, which may progress to end-stage kidney disease. The control of hyperglycemia is usually not sufficient to halt this progression. The kidney damage is quantitatively and qualitatively different in the two forms of diabetes; the typical nodular fibrosis (Kimmelstiel Wilson nodules) appears mostly in type 1 DM, whereas glomerulomegaly is primarily present in type 2 obese DM. An analysis of the different metabolites and hormones in type 1 and type 2 DM and their differential pharmacological treatments might be helpful to advance the hypotheses on the different histopathological patterns of the kidneys and their responses to sodium/glucose transporter type 2 inhibitors (SGLT2i). Full article
(This article belongs to the Special Issue Diabetes Prevention and Intervention)
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