Biomaterials and Biomechanics Studies in Tissue Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 878

Special Issue Editors

Department of Biological & Agricultural Engineering, Louisiana State University, Baton Rouge, LA, USA
Interests: biomechanics; growth; remodeling; artery; vessel; valve; mechanobiology; image processing; machine learning; statistics; soft tissue; Bayesian; uncertainty quantification; analysis; finite element; simulation; regression; patient-specific; subject-specific
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Guest Editor
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, USA
Interests: cell mechanics; fibrosis; immunology; modeling; biomaterials
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Guest Editor
Research and Development, Namida Lab, Fayetteville, AR, USA
Interests: biomaterials; tissue engineering; mechanobiology; biomarker discovery; cancer
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Special Issue Information

Dear Colleagues,

Tissue engineering is a multidisciplinary field that aims to create functional tissues and organs for various applications, including the fabrication of scaffolds for regenerative medicine, the development of experimental platforms for ex vivo disease modeling, and preclinical validation of novel treatments. One of the key challenges in tissue engineering is designing and fabricating biomaterials that can mimic the native structure and function as well as the mechanical and biochemical properties of the target tissues.

This Special Issue aims to provide a comprehensive overview of the current state of the art in biomaterials and biomechanics studies relevant to tissue engineering, with the ultimate goal of stimulating further research and innovation in this exciting and rapidly evolving field. We welcome the submission of both original research and review articles addressing a wide range of topics, including, but not limited to, the following:

  • The design and synthesis of novel biomaterials, such as hydrogels, nanomaterials, composites, and scaffolds, for tissue engineering applications.
  • Characterization and evaluation of the physical, chemical, biological, and mechanical properties of biomaterials and their interactions with cells and tissues.
  • Developments and innovations in fabrication techniques, such as 3D printing, electrospinning, microfluidics, and bioprinting, for creating complex and functional tissue constructs.
  • Modeling and simulation of the biomechanical behavior of biomaterials and tissues under physiological and/or pathophysiological loading conditions.
  • The application and evaluation of biomaterials and tissue constructs within various tissue engineering contexts and applications of interest, including bone, cartilage, skin, muscle, and cardiovascular tissues.

Dr. Bruno Rego
Dr. Alex Khang
Dr. Prashanth Ravishankar
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • biomechanics
  • mechanobiology
  • tissue engineering
  • regenerative medicine

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Published Papers (1 paper)

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Research

18 pages, 6689 KiB  
Article
Experimental Analysis of Stress Shielding Effects in Screw Spacers Placed in Porcine Spinal Tissue
by Elliot Alonso Alcántara-Arreola, Karla Nayeli Silva-Garcés, Jocabed Mendoza-Martínez, Miguel Antonio Cardoso-Palomares and Christopher René Torres-SanMiguel
J. Funct. Biomater. 2024, 15(8), 238; https://doi.org/10.3390/jfb15080238 - 22 Aug 2024
Cited by 1 | Viewed by 593
Abstract
Bone cortical tissues reorganize and remodel in response to tensile forces acting on them, while compressive forces cause atrophy. However, implants support most of the payload. Bones do not regenerate, and stress shielding occurs. The aim is to analyze the biomechanical behavior of [...] Read more.
Bone cortical tissues reorganize and remodel in response to tensile forces acting on them, while compressive forces cause atrophy. However, implants support most of the payload. Bones do not regenerate, and stress shielding occurs. The aim is to analyze the biomechanical behavior of a lumbar cage to study the implant’s stress shielding. The ASTM E-9 standard was used with the necessary adjustments to perform compression tests on lumbar and thoracic porcine spinal vertebrae. Twelve cases were analyzed: six with the metal prosthesis and six with the PEEK implant. A mathematical model based on the Hertz contact theory is proposed to assess the stress shielding for endoprosthesis used in spine pathologies. The lumbar spacer (screw) helps to reduce the stress shielding effect due to the ACME thread. The best interspinous spacer is the PEEK screw. It does not embed in bone. The deformation capability increases by 11.5% and supports 78.6 kg more than a system without any interspinous spacer. Full article
(This article belongs to the Special Issue Biomaterials and Biomechanics Studies in Tissue Engineering)
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