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Functional Hydrogels for Tissue Engineering and Regenerative Medicine
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Functional Hydrogels for Tissue Engineering and Regenerative Medicine

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1618

Special Issue Editors

Prof. Dr. Weifeng Zhao

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Guest Editor
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, China
Interests: biomaterials; hydrogels; blood purification; functional polymers; microspheres; biomacromolecules
Prof. Dr. Baolin Guo

E-Mail Website
Guest Editor
1. Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China
2. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710049, China
Interests: biomaterials; tissue engineering; drug delivery; smart hydrogel; conductive polymers; wound dressing; polymeric hemostat
Special Issues, Collections and Topics in MDPI journals
Dr. Quanbing Mou

E-Mail Website
Guest Editor
Department of Chemistry, The University of Texas at Austin, Austin, TX, USA
Interests: DNA nanotechnology; drug delivery; biosensing; DNAzyme; aptamer; super-resolution imaging; gene editing
Dr. Xin Song

E-Mail Website
Guest Editor
Department of Materials, Imperial College London, London, UK
Interests: hydrogels; blood purification; microrobots; drug delivery; bio-inspired systems; 3D printing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue engineering is an important field of regenerative medicine, which combines scaffolds and cell transplantation to develop substitute tissues and/or promote tissue regeneration, either with or without drug delivery. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, provide mechanical support for the cells in the engineered tissues, and simulate the native extracellular matrix. This Special Issue aims to collect research and review papers concerning the properties, structure, synthesis and fabrication methods, and applications of hydrogels in tissue engineering.

Prof. Dr. Weifeng Zhao
Prof. Dr. Baolin Guo
Dr. Quanbing Mou
Dr. Xin Song
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • tissue engineering
  • regeneration medicine
  • smart materials
  • scaffolds
  • drug/cell delivery
  • functional polymers

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Published Papers (1 paper)

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Research

16 pages, 3539 KiB  
Article
Formulation Effects on the Mechano-Physical Properties of In Situ-Forming Resilient Hydrogels for Breast Tissue Regeneration
by Daniella Goder Orbach and Meital Zilberman
J. Funct. Biomater. 2024, 15(7), 176; https://doi.org/10.3390/jfb15070176 - 28 Jun 2024
Viewed by 867
Abstract
The need for a long-term solution for filling the defects created during partial mastectomies due to breast cancer diagnosis has not been met to date. All available defect-filling methods are non-permanent and necessitate repeat procedures. Here, we report on novel injectable porous hydrogel [...] Read more.
The need for a long-term solution for filling the defects created during partial mastectomies due to breast cancer diagnosis has not been met to date. All available defect-filling methods are non-permanent and necessitate repeat procedures. Here, we report on novel injectable porous hydrogel structures based on the natural polymers gelatin and alginate, which are designed to serve for breast reconstruction and regeneration following partial mastectomy. The effects of the formulation parameters on the mechanical and physical properties were thoroughly studied. The modulus in compression and tension were in the range of native breast tissue. Both increased with the increase in the crosslinker concentration and the polymer–air ratio. Resilience was very high, above 93% for most studied formulations, allowing the scaffold to be continuously deformed without changing its shape. The combination of high resilience and low elastic modulus is favored for adipose tissue regeneration. The physical properties of gelation time and water uptake are controllable and are affected mainly by the alginate and N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC) concentrations and less by the polymer–air ratio. In vitro cell viability tests were performed on mouse preadipocytes and indicated high biocompatibility. The minimally invasive nature of this approach, along with the excellent properties of the scaffold, will enable the filling of complex voids while simultaneously decreasing surgical costs and greatly improving patient well-being. Full article
(This article belongs to the Special Issue Functional Hydrogels for Tissue Engineering and Regenerative Medicine)
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