Bioactive Elements for Tissue Regeneration

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 2544

Special Issue Editors

Institute of Translational Medicine, Shanghai University, Shanghai, China
Interests: bone/cartilage regeneration; bioactive materials; osteoarthritis; cell regulation; organoid
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
Interests: biomaterials; titanium and its alloys; graphene; surfaces and interfaces; tissue engineering
School of Material Science and Engineering, South China University of Technology, Guangzhou, China
Interests: electroactive biomaterials; bone; cell differentiation; implant; antibacterial
State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an, China
Interests: biometals; surface modification; osteoimmunomodulation; anti-bacteria; osseointegration

Special Issue Information

Dear Colleagues,

With the emergence of an aging society, more and more people are suffering from aging-related diseases, such as osteoarthritis, bone defects and so on. For this reason, more and more biomaterials have been developed and investigated to meet the clinical demand. However, only a very limited number of biomaterials have been successfully translated into clinical applications. Bioactive elements, such as Ca, Mg and Sr,  play important roles in human metabolism and tissue regeneration and thus have a good clinical application prospect. Therefore, it is of great significance to develop bioactive elements-contained biomaterials that enhance the success of efforts to promote tissue regeneration and eventually overcome challenges for their future clinical translation.

This Special Issue, "Bioactive Elements for Tissue Regeneration", aims to present major advances in the field of tissue regeneration and the recent progress of bioactive elements for tissue repair and regeneration. This Special Issue accepts original research and reviews about bioactive elements, novel biomaterials, biofabrication technologies, molecular mechanisms, and other therapeutic approaches for tissue regeneration.

The topics and themes of this research topic will include, but are not limited to, the following:

  • Novel bioactive elements-contained biomaterials fabrication methods and technologies;
  • Novel molecular mechanism studies on bone/cartilage regeneration and repair;
  • Bioactive elements for the regeneration of bone, cartilage, ligaments, tendons, and skin;
  • Novel material biological effects of bioactive elements;
  • Challenges and opportunities of bioactive elements in clinical transformation;
  • Development of bioactive elements-contained biomaterials for potential clinical application.

Dr. Zhen Geng
Dr. Jiajun Qiu
Dr. Peng Yu
Dr. Bo Li
Guest Editors

Manuscript Submission Information

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Keywords

  • bioactive elements
  • tissue regeneration
  • materiobiology
  • cell regulation
  • molecular mechanism
  • clinical transformation

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Published Papers (1 paper)

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Research

16 pages, 4274 KiB  
Article
Microporous Implants Modified by Bifunctional Hydrogel with Antibacterial and Osteogenic Properties Promote Bone Integration in Infected Bone Defects
by Yiping Pu, Xuecai Lin, Qiang Zhi, Shichong Qiao and Chuangqi Yu
J. Funct. Biomater. 2023, 14(4), 226; https://doi.org/10.3390/jfb14040226 - 16 Apr 2023
Cited by 5 | Viewed by 2037
Abstract
Prosthesis implantation and bone integration under bacterial infection are arduous challenges in clinical practice. It is well known that the reactive oxygen species (ROS) produced by bacterial infection around the bone defects will further hinder bone healing. To solve this problem, we prepared [...] Read more.
Prosthesis implantation and bone integration under bacterial infection are arduous challenges in clinical practice. It is well known that the reactive oxygen species (ROS) produced by bacterial infection around the bone defects will further hinder bone healing. To solve this problem, we prepared a ROS-scavenging hydrogel by cross-linking polyvinyl alcohol and a ROS-responsive linker, N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-tetramethylpropane-1, 3-diaminium, to modify the microporous titanium alloy implant. The prepared hydrogel was used as an advanced ROS-scavenging tool to promote bone healing by inhibiting the ROS levels around the implant. Bifunctional hydrogel serving as a drug delivery system can release therapeutic molecules, including vancomycin, to kill bacteria and bone morphogenetic protein-2 to induce bone regeneration and integration. This multifunctional implant system that combines mechanical support and disease microenvironment targeting provides a novel strategy for bone regeneration and integration of implants in infected bone defects. Full article
(This article belongs to the Special Issue Bioactive Elements for Tissue Regeneration)
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