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Functional Biomaterials and Skin Wound Healing
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Functional Biomaterials and Skin Wound Healing

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (1 February 2024) | Viewed by 8586

Special Issue Editor

Dr. Suneel Kumar

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Guest Editor
Department of Biomedical Engineering, Rutgers, The State University of New Jersey, 599 Taylor Road, Piscataway, NJ 08854, USA
Interests: spinal cord injury; wound healing; stem cells; bioengineering; self-assembled nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic wounds are characterized as non-healing wounds due to poor angiogenesis, impaired vascularization, collagen formation, and dysfunctional fibroblasts and keratinocytes in the hypoxic wound environment. These chronic wounds initially resulted from pathological conditions such as diabetes, neuronal trauma (CNS injuries), and burn injuries. These wounds are secondarily affected by several bacterial population. Recently, there has been much debate regarding bio-inspired functional biomaterials and their role in skin wound healing and bacterial disinfection directly or indirectly. In this Special Issue, we will focus on applications of these functional biomaterials in skin wound healing and study their response under challenging pathological conditions using in vitro, in vivo, and ex vivo systems. Due to the wide scope of these biomaterials, contributions relating to biomaterials, incorporated biomaterials (e.g., skin substitute), CNS injuries, tissue engineering, and biomimetics are also welcome.

Dr. Suneel Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • nanoparticles
  • spinal cord injury
  • traumatic brain injury
  • pressure ulcer
  • wound healing
  • diabetes
  • burn injury

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Published Papers (3 papers)

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Research

20 pages, 1576 KiB  
Article
Carboxymethyl Chitosan Hydrogels for Effective Wound Healing—An Animal Study
by Karol Kamil Kłosiński, Radosław Aleksander Wach, Weronika Kruczkowska, Łukasz Duda, Damian Kołat, Żaneta Kałuzińska-Kołat, Piotr Tomasz Arkuszewski and Zbigniew Włodzimierz Pasieka
J. Funct. Biomater. 2023, 14(9), 473; https://doi.org/10.3390/jfb14090473 - 15 Sep 2023
Cited by 2 | Viewed by 2299
Abstract
Hydrogels have various applications in medicine, for example, in systems for controlled drug release or as wound dressings, where they provide an appropriate environment for healing and constitute a barrier to microorganisms. The aim of this study was to evaluate the action of [...] Read more.
Hydrogels have various applications in medicine, for example, in systems for controlled drug release or as wound dressings, where they provide an appropriate environment for healing and constitute a barrier to microorganisms. The aim of this study was to evaluate the action of carboxymethyl chitosan (CMCS) hydrogels in wound healing therapy in vivo using a laboratory rat model. The hydrogels were formed from aqueous solutions of a CMCS biopolymer via electron beam irradiation, with the presence of a crosslinking agent of poly(ethylene glycol) diacrylate. A histopathological examination of injured tissue, using a model of a hard-to-heal wound, indicated that the CMCS hydrogel supported healing. The new gel dressing, being noncytotoxic, presents great potential in wound treatment, with positive effects on the amount of inflammatory infiltration, young collagen formation, and the degree of epidermalization. A key advantage of the current approach (i.e., using competitive radiation technology for synthesis) is that it includes only one step, with the product being sterilized as it is synthesized. The hydrogel effectively supports wound healing and can serve as a bio-based and biodegradable platform for other medical applications. Full article
(This article belongs to the Special Issue Functional Biomaterials and Skin Wound Healing)
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19 pages, 7247 KiB  
Article
Blending Ethnomedicine with Modern Technology—From Conventional to Tailored Products: Modulating Biopharmaceutical Properties of Berberis Extract by Solid Lipid Nanoparticles for Wound Healing
by Neetika Sharma, Karan Vasisht, Jasmine Kaur, Simarjot Kaur Sandhu, Kaustav Dey, Bakr Ahmed Hameed, Rakesh Bajaj, Indu Pal Kaur and Maninder Karan
J. Funct. Biomater. 2023, 14(8), 418; https://doi.org/10.3390/jfb14080418 - 9 Aug 2023
Cited by 5 | Viewed by 1546
Abstract
Drug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated with herbal medicines, such as low solubility [...] Read more.
Drug-delivery systems employing phytopharmaceuticals based on the leads in traditional knowledge offers not only an alternative but quicker and more economic strategy for drug development. Nanophytopharmaceuticals promise remarkable opportunities with the ability to overcome challenges associated with herbal medicines, such as low solubility and bioavailability, poor target specificity, and shelf life. Berberis extracts documented as Ropana (wound healer) in Sushruta Samhita are a popular traditional remedy that is amiss in the modern system of medicine as it exhibits very poor biopharmaceutical properties. Poor solubility and bioavailability necessitate the administration of high doses to achieve the desired therapeutic effects. Exploiting the diversified type of compounds with pleiotropic properties present in Berberis, the biopharmaceutical properties were engineered using an optimized freeze-dried extract and developed solid lipid nanoparticles (SLNs) as an effective drug-delivery system. An industrially viable and environment-friendly hot high-pressure homogenization technique led to a stable formulation with an average particle size of 178.4 nm, as well as a 7-fold increase in loading and a significant entrapment of 91 ± 1.25%. The pharmacodynamic studies of developed nanosystems in excision-wound models showed faster and complete healing of wounds with no scars. Full article
(This article belongs to the Special Issue Functional Biomaterials and Skin Wound Healing)
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14 pages, 3145 KiB  
Article
Full Skin Equivalent Models for Simulation of Burn Wound Healing, Exploring Skin Regeneration and Cytokine Response
by Patrick P. G. Mulder, Rajiv S. Raktoe, Marcel Vlig, Anouk Elgersma, Esther Middelkoop and Bouke K. H. L. Boekema
J. Funct. Biomater. 2023, 14(1), 29; https://doi.org/10.3390/jfb14010029 - 4 Jan 2023
Cited by 3 | Viewed by 4071
Abstract
Healing of burn injury is a complex process that often leads to the development of functional and aesthetic complications. To study skin regeneration in more detail, organotypic skin models, such as full skin equivalents (FSEs) generated from dermal matrices, can be used. Here, [...] Read more.
Healing of burn injury is a complex process that often leads to the development of functional and aesthetic complications. To study skin regeneration in more detail, organotypic skin models, such as full skin equivalents (FSEs) generated from dermal matrices, can be used. Here, FSEs were generated using de-epidermalized dermis (DED) and collagen matrices MatriDerm® and Mucomaix®. Our aim was to validate the MatriDerm- and Mucomaix-based FSEs for the use as in vitro models of wound healing. Therefore, we first characterized the FSEs in terms of skin development and cell proliferation. Proper dermal and epidermal morphogenesis was established in all FSEs and was comparable to ex vivo human skin models. Extension of culture time improved the organization of the epidermal layers and the basement membrane in MatriDerm-based FSE but resulted in rapid degradation of the Mucomaix-based FSE. After applying a standardized burn injury to the models, re-epithelization occurred in the DED- and MatriDerm-based FSEs at 2 weeks after injury, similar to ex vivo human skin. High levels of pro-inflammatory cytokines were present in the culture media of all models, but no significant differences were observed between models. We anticipate that these animal-free in vitro models can facilitate research on skin regeneration and can be used to test therapeutic interventions in a preclinical setting to improve wound healing. Full article
(This article belongs to the Special Issue Functional Biomaterials and Skin Wound Healing)
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