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Applications of Biomaterials in Otorhinolaryngology
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Applications of Biomaterials in Otorhinolaryngology

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 4198

Special Issue Editors

Dr. Shih-Han Hung

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Guest Editor
Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
Interests: otolaryngology; head and neck oncology; biomaterials; tissue engineering
Prof. Dr. Kuo-Sheng Lee

E-Mail Website
Guest Editor
Department of Otolaryngology, School of Medicine, College of Medicine, Mackay Medical College, Taipei, Taiwan
Interests: otolaryngology; pediatrics; laryngology; trachea; reconstruction; tissue engineering
Dr. Chin-Hui Su

E-Mail Website
Guest Editor
Department of Otolaryngology, School of Medicine, College of Medicine, Mackay Medical College, Taipei, Taiwan
Interests: otolaryngology; paediatrics; laryngology; salivary gland; sialendoscopy; tissue engineering

Special Issue Information

Dear Colleagues,

Otorhinolaryngology is regarded as one of the medical specialties with the widest varieties. Throughout the upper aerodigestive tract, various types of management were applied in sub-fields, including otology, rhinology, laryngology, and head and neck surgery. Materials with different utilities have been widely used in these applications, and improvements in material science greatly enhance the surgical/therapeutic outcomes in these patients. Used for simple purposes, such as hemostasis, during operation and due to their antimicrobial activities, enormous emphasis has been placed on materials supporting or facilitating wound healing and tissue growth as these materials release bioactive molecules on demand and are able to support the biological functions of living tissue and encourage regeneration. Modern materials are further utilized in the field of tissue engineering as factors inducing angiogenesis, signal delivery, cell recruitment, scaffold stability, electrical conductivity in nerve and cardiac regeneration, and adhesion ability for tissue approximation, as well as providing microbial barriers, which are all critical considerations.

This Special Issue aims to incorporate research papers, communications, and review articles that report on the application of biomaterials in otorhinolaryngological head and neck surgery. Through this, we hope the readers will gain a more comprehensive understanding of progress in materials science and further explore the possibilities of applying these innovations in the field of otorhinolaryngology. Related submissions regarding regenerative medicine and tissue engineering are also highly recommended.

Dr. Shih-Han Hung
Prof. Dr. Kuo-Sheng Lee
Dr. Chin-Hui Su
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • hemostasis
  • tissue repair
  • otorhinolaryngology
  • otology
  • rhinology
  • laryngology
  • head and neck

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Published Papers (2 papers)

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Research

11 pages, 1676 KiB  
Article
Biomaterial Material Applications in Postoperative Surgical Fields of Uvulopalatopharyngoplasty: A Comparative Study
by Tsung-Che Yu, Ting-Chieh Huang, Po-Yueh Chen, Chun-Che Shih and Wei-Wen Chang
J. Funct. Biomater. 2023, 14(7), 337; https://doi.org/10.3390/jfb14070337 - 26 Jun 2023
Viewed by 1517
Abstract
This retrospective study compared the effectiveness of different materials used in Uvulopalatopharyngoplasty (UPPP) for snoring or obstructive sleep apnea treatment, focusing on the impact on bleeding control, pain control, and healing ability. The study population comprised 213 patients who underwent UPPP at Wan-Fang [...] Read more.
This retrospective study compared the effectiveness of different materials used in Uvulopalatopharyngoplasty (UPPP) for snoring or obstructive sleep apnea treatment, focusing on the impact on bleeding control, pain control, and healing ability. The study population comprised 213 patients who underwent UPPP at Wan-Fang Hospital between July 2018 and October 2022 divided into four groups based on the postoperative material used: No Material Use Group, Tissue Glue Group, Platelet-Rich Plasma (PRP) Group, and Polyglycolic Acid (PGA) Sheet Group. Results showed significant differences in operation time and intraoperative bleeding amount among the groups, with the Tissue Glue Group demonstrating the shortest operation time. While no significant differences in postoperative pain at 24 h were observed, PRP and PGA Sheet groups exhibited lower average pain scores in cases with higher pain levels. Postoperative complications and emergency room visits due to pain or bleeding varied among the groups, with the No Material Use Group having the highest incidence, although no statistical significance was achieved. This study provides insights into the potential benefits of using advanced materials in UPPP, guiding future research and clinical practice to improve patient care and outcomes. Full article
(This article belongs to the Special Issue Applications of Biomaterials in Otorhinolaryngology)
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14 pages, 2418 KiB  
Article
Degassing a Decellularized Scaffold Enhances Wound Healing and Reduces Fibrosis during Tracheal Defect Reconstruction: A Preliminary Animal Study
by Nguyen-Kieu Viet-Nhi, Yen-Chun Chen, Luong Huu Dang, How Tseng and Shih-Han Hung
J. Funct. Biomater. 2023, 14(3), 147; https://doi.org/10.3390/jfb14030147 - 5 Mar 2023
Cited by 1 | Viewed by 2131
Abstract
Few efforts have been made regarding the optimization of porcine small intestinal submucosa (SIS) to improve its biocompatibility. This study aims to evaluate the effect of SIS degassing on the promotion of cell attachment and wound healing. The degassed SIS was evaluated in [...] Read more.
Few efforts have been made regarding the optimization of porcine small intestinal submucosa (SIS) to improve its biocompatibility. This study aims to evaluate the effect of SIS degassing on the promotion of cell attachment and wound healing. The degassed SIS was evaluated in vitro and in vivo, compared with the nondegassed SIS control. In the cell sheet reattachment model, the reattached cell sheet coverage was significantly higher in the degassed SIS group than in the nondegassed group. Cell sheet viability was also significantly higher in the SIS group than in the control group. In vivo studies showed that the tracheal defect repaired by the degassed SIS patch showed enhanced healing and reductions in fibrosis and luminal stenosis compared to the nondegassed SIS control group, with the thickness of the transplanted grafts in the degassed SIS group significantly lower than those in the control group (346.82 ± 28.02 µm vs. 771.29 ± 20.41 µm, p < 0.05). Degassing the SIS mesh significantly promoted cell sheet attachment and wound healing by reducing luminal fibrosis and stenosis compared to the nondegassed control SIS. The results suggest that the degassing processing might be a simple and effective way to improve the biocompatibility of SIS. Full article
(This article belongs to the Special Issue Applications of Biomaterials in Otorhinolaryngology)
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