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Hydroxyapatite Composites for Biomedical Application
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Hydroxyapatite Composites for Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: 20 January 2025 | Viewed by 5392

Special Issue Editors

Dr. Vladyslav Vivcharenko

E-Mail Website
Guest Editor
Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Interests: cell biology; biomaterials; bioceramics; hydroxyapatite; tissue engineering; cell culture models; stem cells
Dr. Paulina Kazimierczak

E-Mail Website
Guest Editor
Independent Unit of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland
Interests: biomaterial synthesis; scaffolds; hydroxyapatite ceramic; 3D cell culture; regenerative medicine; tissue regeneration

Special Issue Information

Dear Colleagues,

According to the scientific literature, hydroxyapatite is the predominant type of calcium phosphate (CaP) used in biomedical applications. Its structural similarity to the mineral part of bones’ extracellular matrix explains the preference for its use over other CaPs. Hydroxyapatite is widely used in dental tissue regeneration, maxillofacial surgeries and orthopedic filling bone defects. Its use has been extensively researched; however, in the last few years, an increasing number of studies based on the preparation of modern novel biomaterials for hard tissue regeneration have been observed. The main reason for this observed phenomenon is the emergence of innovative attempts to overcome the limitations of the abovementioned ceramics in terms of their mechanical and microstructural properties, as well as trials aiming to develop innovative modern biomaterials dedicated to specific biomedical applications.

This Special Issue aims to highlight recent advances in the fabrication, characterization and potential usage of novel hydroxyapatite-based biomaterials in biomedical engineering applications. Special emphasis will be placed on comprehensive biological and physico-chemical evaluations and the potential applications of produced composites. Breakthrough scientific research as well as advanced review papers that contribute to the main topic are welcome.

Dr. Vladyslav Vivcharenko
Dr. Paulina Kazimierczak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydroxyapatite ceramic
  • scaffolds
  • biomaterials
  • biocompatibility
  • physico-chemical properties
  • composites
  • biomedical applications

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Published Papers (3 papers)

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Research

16 pages, 4448 KiB  
Article
Hybrid Bone Substitute Containing Tricalcium Phosphate and Silver Modified Hydroxyapatite–Methylcellulose Granules
by Joanna P. Czechowska, Annett Dorner-Reisel and Aneta Zima
J. Funct. Biomater. 2024, 15(7), 196; https://doi.org/10.3390/jfb15070196 - 17 Jul 2024
Viewed by 1083
Abstract
Despite years of extensive research, achieving the optimal properties for calcium phosphate-based biomaterials remains an ongoing challenge. Recently, ‘biomicroconcretes’ systems consisting of setting-phase-forming bone cement matrix and aggregates (granules/microspheres) have been developed and studied. However, further investigations are necessary to clarify the complex [...] Read more.
Despite years of extensive research, achieving the optimal properties for calcium phosphate-based biomaterials remains an ongoing challenge. Recently, ‘biomicroconcretes’ systems consisting of setting-phase-forming bone cement matrix and aggregates (granules/microspheres) have been developed and studied. However, further investigations are necessary to clarify the complex interplay between the synthesis, structure, and properties of these materials. This article focusses on the development and potential applications of hybrid biomaterials based on alpha-tricalcium phosphate (αTCP), hydroxyapatite (HA) and methylcellulose (MC) modified with silver (0.1 wt.% or 1.0 wt.%). The study presents the synthesis and characterization of silver-modified hybrid granules and seeks to determine the possibility and efficiency of incorporating these hybrid granules into αTCP-based biomicroconcretes. The αTCP and hydroxyapatite provide structural integrity and osteoconductivity, the presence of silver imparts antimicrobial properties, and MC allows for the self-assembling of granules. This combination creates an ideal environment for bone regeneration, while it potentially may prevent bacterial colonization and infection. The material’s chemical and phase composition, setting times, compressive strength, microstructure, chemical stability, and bioactive potential in simulated body fluid are systematically investigated. The results of the setting time measurements showed that both the size and the composition of granules (especially the hybrid nature) have an impact on the setting process of biomicroconcretes. The addition of silver resulted in prolonged setting times compared to the unmodified materials. Developed biomicroconcretes, despite exhibiting lower compressive strength compared to traditional calcium phosphate cements, fall within the range of human cancellous bone and demonstrate chemical stability and bioactive potential, indicating their suitability for bone substitution and regeneration. Further in vitro studies and in vivo assessments are needed to check the potential of these biomaterials in clinical applications. Full article
(This article belongs to the Special Issue Hydroxyapatite Composites for Biomedical Application)
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22 pages, 10260 KiB  
Article
Alginate-Sr/Mg Containing Bioactive Glass Scaffolds: The Characterization of a New 3D Composite for Bone Tissue Engineering
by Benedetta Guagnini, Barbara Medagli, Bianca Zumbo, Valeria Cannillo, Gianluca Turco, Davide Porrelli and Devis Bellucci
J. Funct. Biomater. 2024, 15(7), 183; https://doi.org/10.3390/jfb15070183 - 2 Jul 2024
Cited by 1 | Viewed by 1636
Abstract
In bone regeneration, combining natural polymer-based scaffolds with Bioactive Glasses (BGs) is an attractive strategy to improve the mechanical properties of the structure, as well as its bioactivity and regenerative potential. Methods: For this purpose, a well-studied alginate/hydroxyapatite (Alg/HAp) porous scaffold was enhanced [...] Read more.
In bone regeneration, combining natural polymer-based scaffolds with Bioactive Glasses (BGs) is an attractive strategy to improve the mechanical properties of the structure, as well as its bioactivity and regenerative potential. Methods: For this purpose, a well-studied alginate/hydroxyapatite (Alg/HAp) porous scaffold was enhanced with an experimental bioglass (BGMS10), characterized by a high crystallization temperature and containing therapeutic ions such as strontium and magnesium. This resulted in an improved biological response compared to 45S5 Bioglass®, the “gold” standard among BGs. Porous composite scaffolds were fabricated by freeze-drying technique and characterized by scanning electron microscopy and microanalysis, infrared spectroscopy, and microcomputed tomography. The mechanical properties and cytocompatibility of the new scaffold composition were also evaluated. The addition of bioglass to the Alg/HAp network resulted in a slightly lower porosity. However, despite the change in pore size, the MG-63 cells were able to better adhere and proliferate when cultured for one week on a BG scaffold compared to the control Alg/HAp scaffolds. Thus, our findings indicate that the combination of bioactive glass BGMS10 does not affect the structural and physicochemical properties of the Alg/HAp scaffold and confers bioactive properties to the structures, making the Alg/HAp-BGMS10 scaffold a promising candidate for future application in bone tissue regeneration. Full article
(This article belongs to the Special Issue Hydroxyapatite Composites for Biomedical Application)
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20 pages, 6235 KiB  
Article
Generation of Pearl/Calcium Phosphate Composite Particles and Their Integration into Porous Chitosan Scaffolds for Bone Regeneration
by Zhiyi Li, Ihtesham Ur Rehman, Rebecca Shepherd and Timothy E. L. Douglas
J. Funct. Biomater. 2024, 15(3), 55; https://doi.org/10.3390/jfb15030055 - 21 Feb 2024
Viewed by 2123
Abstract
Bone tissue engineering using osteoconductive scaffolds holds promise for regeneration, with pearl powder gaining interest for its bioactive qualities. This study used freeze drying to create chitosan (CS) scaffolds with pearl/calcium phosphate (p/CaP) powders, mimicking bone tissue structurally and compositionally. Characterization included scanning [...] Read more.
Bone tissue engineering using osteoconductive scaffolds holds promise for regeneration, with pearl powder gaining interest for its bioactive qualities. This study used freeze drying to create chitosan (CS) scaffolds with pearl/calcium phosphate (p/CaP) powders, mimicking bone tissue structurally and compositionally. Characterization included scanning electron microscopy (SEM) and mechanical testing. X-ray diffraction (XRD) Fourier-transform infrared–photoacoustic photo-acoustic sampling (FTIR−PAS), and FTIR- attenuated total reflectance (FTIR-ATR) were used to characterize p/CaP. In vitro tests covered degradation, cell activity, and SEM analysis. The scaffolds showed notable compressive strength and modulus enhancements with increasing p/CaP content. Porosity, ranging from 60% to 90%, decreased significantly at higher pearl/CaP ratios. Optimal cell proliferation and differentiation were observed with scaffolds containing up to 30 wt.% p/CaP, with 30 wt.% pearl powder and 30 wt.% p/CaP yielding the best results. In conclusion, pearl/calcium phosphate chitosan (p/CaP_CS) composite scaffolds emerged as promising biomaterials for bone tissue engineering, combining structural mimicry and favourable biological responses. Full article
(This article belongs to the Special Issue Hydroxyapatite Composites for Biomedical Application)
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