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Recent Advances in Bioactive Glasses
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Recent Advances in Bioactive Glasses

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 February 2018) | Viewed by 42095

Special Issue Editor

Dr. Francesco Baino

E-Mail Website
Guest Editor
Institute of Materials Physics and Engineering, Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy
Interests: ceramics; glasses; porous materials; additive manufacturing; bioactive glasses; bioceramics; composites; tissue engineering; multifunctional biomaterials; biomedical scaffolds; advanced ceramics; sustainable materials; waste management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The variety of applications of bioactive glasses in medicine has expanded tremendously over recent years. Initially developed as bioactive materials to fill bone defects and promote the healing of hard tissues in orthopaedics and dentistry, bioactive glasses have more recently proved their suitability for a range of emerging applications in contact with soft tissues. Bioactive glasses are characterized by a great versatility from the viewpoints of composition and manufacturing, on which researchers can act to develop new biomaterials and implants for tissue repair and advanced therapy (e.g. cancer treatment, drug release, antimicrobial effect). Many of these novel applications seemed impossible when research began almost 50 years ago, which suggests that the potential of bioactive glasses is still far from being fully exploited and highly motivates further research.

The aim of this Special Issue is to provide a picture of the latest achievements in the field of bioactive glasses, with special emphasis on novel design and synthesis approaches, characterization and manufacturing strategies, and new applications for healthcare.

It is my pleasure to invite you to submit a manuscript for this Special Issue. Full research articles, short communications and comprehensive review papers focusing on the above-mentioned topics are welcome.

Dr. Francesco Baino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioactive glasses

  • Glass–ceramics

  • Composites

  • Scaffolds

  • Bone and dental repair

  • Tissue engineering

  • Surface functionalization

  • Drug release

  • Additive manufacturing

  • Organic–inorganic hybrids

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Published Papers (3 papers)

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Research

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3004 KiB  
Article
The Feasibility and Functional Performance of Ternary Borate-Filled Hydrophilic Bone Cements: Targeting Therapeutic Release Thresholds for Strontium
by Kathleen MacDonald, Richard B. Price and Daniel Boyd
J. Funct. Biomater. 2017, 8(3), 28; https://doi.org/10.3390/jfb8030028 - 14 Jul 2017
Cited by 3 | Viewed by 6223
Abstract
We examine the feasibility and functionality of hydrophilic modifications to a borate glass reinforced resin composite; with the objective of meeting and maintaining therapeutic thresholds for Sr release over time, as a potential method of incorporating antiosteoporotic therapy into a vertebroplasty material. Fifteen [...] Read more.
We examine the feasibility and functionality of hydrophilic modifications to a borate glass reinforced resin composite; with the objective of meeting and maintaining therapeutic thresholds for Sr release over time, as a potential method of incorporating antiosteoporotic therapy into a vertebroplasty material. Fifteen composites were formulated with the hydrophilic agent hydroxyl ethyl methacrylate (HEMA, 15, 22.5, 30, 37.5 or 45 wt% of resin phase) and filled with a borate glass (55, 60 or 65 wt% of total cement) with known Sr release characteristics. Cements were examined with respect to degree of cure, water sorption, Sr release, and biaxial flexural strength over 60 days of incubation in phosphate buffered saline. While water sorption and glass degradation increased with increasing HEMA content, Sr release peaked with the 30% HEMA compositions, scanning electron microscope (SEM) imaging confirmed the surface precipitation of a Sr phosphate compound. Biaxial flexural strengths ranged between 16 and 44 MPa, decreasing with increased HEMA content. Degree of cure increased with HEMA content (42 to 81%), while no significant effect was seen on setting times (209 to 263 s). High HEMA content may provide a method of increasing monomer conversion without effect on setting reaction, providing sustained mechanical strength over 60 days. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Glasses)
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Review

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26 pages, 2965 KiB  
Review
Bioactive Glasses: Where Are We and Where Are We Going?
by Francesco Baino, Sepideh Hamzehlou and Saeid Kargozar
J. Funct. Biomater. 2018, 9(1), 25; https://doi.org/10.3390/jfb9010025 - 19 Mar 2018
Cited by 366 | Viewed by 20476
Abstract
Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of [...] Read more.
Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Glasses)
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33 pages, 4357 KiB  
Review
Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies
by Elisa Fiume, Jacopo Barberi, Enrica Verné and Francesco Baino
J. Funct. Biomater. 2018, 9(1), 24; https://doi.org/10.3390/jfb9010024 - 16 Mar 2018
Cited by 228 | Viewed by 13997
Abstract
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone [...] Read more.
Nowadays, bioactive glasses (BGs) are mainly used to improve and support the healing process of osseous defects deriving from traumatic events, tumor removal, congenital pathologies, implant revisions, or infections. In the past, several approaches have been proposed in the replacement of extensive bone defects, each one with its own advantages and drawbacks. As a result, the need for synthetic bone grafts is still a remarkable clinical challenge since more than 1 million bone-graft surgical operations are annually performed worldwide. Moreover, recent studies show the effectiveness of BGs in the regeneration of soft tissues, too. Often, surgical criteria do not match the engineering ones and, thus, a compromise is required for getting closer to an ideal outcome in terms of good regeneration, mechanical support, and biocompatibility in contact with living tissues. The aim of the present review is providing a general overview of BGs, with particular reference to their use in clinics over the last decades and the latest synthesis/processing methods. Recent advances in the use of BGs in tissue engineering are outlined, where the use of porous scaffolds is gaining growing importance thanks to the new possibilities given by technological progress extended to both manufacturing processes and functionalization techniques. Full article
(This article belongs to the Special Issue Recent Advances in Bioactive Glasses)
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