Personalized Medicine in Neuroscience: Molecular to Systems Approach

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 2436

Special Issue Editor


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Guest Editor
Department of Psychology, Rutgers State University New Brunswick, New Brunswick, NJ 08903, USA
Interests: digital biomarkers; machine learning; artificial intelligence; precision medicine; computational neuroscience; objective behavioral analyses sensory-motor integration; autism; schizophrenia; Parkinson's disease; algorithms for transcriptome interrogation; data mining; signal processing
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Special Issue Information

Dear Colleagues, 

The precision medicine paradigm has emerged as a new platform to connect disparate layers of the knowledge network and integrate information from different subfields of neuroscience. Once the layer of behavioral analysis is improved through precision phenotyping, this emerging platform could provide a roadmap for personalized diagnoses and treatments of neuropsychiatric and neurological disorders’ subtypes, tracked across the human lifespan.

Combining advances in neuroscience with those of other contemporary revolutions, such as genomics and wearable biosensors, the new personalized approach offers new ways to integrate translational and basic research towards improvements in mental and physical health, tailored to societal strata and ultimately to the individual. In the basic science arena, these new methods could help uncover causal mechanistic explanations of brain–body phenomena through objective means that go beyond observation, description, and opinion. In the areas of translation and commercialization, new personalized approaches could offer better ways to diagnose, treat, manage, and track diseases at scale from the comfort of homes, schools, or clinics with the help of research labs.

This new Special Issue seeks papers that explore different areas of research across neuroscience, spanning from molecules to complex social behaviors, aiming at potentially improving medical practices while building new collaborative bridges to scale research and empower patients, researchers, and practicing clinicians.

Submit your paper to the Journal of Personalized Medicine and be part of this new neuroscience-informed clinical revolution.

Prof. Dr. Elizabeth B. Torres
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroscience
  • precision phenotyping
  • neuropsychiatric and neurological disorders
  • genomics
  • wearable biosensors
  • clinical trial

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Published Papers (1 paper)

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Research

26 pages, 2267 KiB  
Article
Temporal Interactions between Maintenance of Cerebral Cortex Thickness and Physical Activity from an Individual Person Micro-Longitudinal Perspective and Implications for Precision Medicine
by John Wall, Hong Xie and Xin Wang
J. Pers. Med. 2024, 14(2), 127; https://doi.org/10.3390/jpm14020127 - 23 Jan 2024
Viewed by 1413
Abstract
Maintenance of brain structure is essential for neurocognitive health. Precision medicine has interests in understanding how maintenance of an individual person’s brain, including cerebral cortical structure, interacts with lifestyle factors like physical activity. Cortical structure, including cortical thickness, has recognized relationships with physical [...] Read more.
Maintenance of brain structure is essential for neurocognitive health. Precision medicine has interests in understanding how maintenance of an individual person’s brain, including cerebral cortical structure, interacts with lifestyle factors like physical activity. Cortical structure, including cortical thickness, has recognized relationships with physical activity, but concepts of these relationships come from group, not individual, focused findings. Whether or how group-focused concepts apply to an individual person is fundamental to precision medicine interests but remains unclear. This issue was studied in a healthy man using concurrent micro-longitudinal tracking of magnetic resonance imaging-defined cortical thickness and accelerometer-defined steps/day over six months. These data permitted detailed examination of temporal relationships between thickness maintenance and physical activity at an individual level. Regression analyses revealed graded significant and trend-level temporal interactions between preceding activity vs. subsequent thickness maintenance and between preceding thickness maintenance vs. subsequent activity. Interactions were bidirectional, delayed/prolonged over days/weeks, positive, bilateral, directionally asymmetric, and limited in strength. These novel individual-focused findings in some ways are predicted, but in other ways remain unaddressed or undetected, by group-focused work. We suggest that individual-focused concepts of temporal interactions between maintenance of cortical structure and activity can provide needed new insight for personalized tailoring of physical activity, cortical, and neurocognitive health. Full article
(This article belongs to the Special Issue Personalized Medicine in Neuroscience: Molecular to Systems Approach)
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