Gene Expression in Personalized Management of Diseases of Civilization

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Omics/Informatics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 2125

Special Issue Editor


E-Mail Website
Guest Editor
Collegium Medicum, WSB Academy, 41-300 Dabrowa Gornicza, Poland
Interests: gene expression; precision oncology; molecular signatures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, entitled "Gene Expression in Personalized Management of Diseases of Civilisation", delves into the burgeoning field of precision medicine, which tailors treatments for individual patients based on their unique genetic profiles. It highlights how the analysis of gene expression patterns in various diseases of civilisation—such as cancer, diabetes, cardiovascular diseases, and neurodegenerative conditions—can guide more precise and effective therapeutic decisions. By examining the activity levels of specific genes, researchers are uncovering molecular markers that can predict a patient's response to different treatments, paving the way for personalized approaches to disease management.

This Special Issue also explores the critical role of genomic technologies, such as next-generation sequencing and microarray analysis, in unraveling complex gene expression profiles. These advanced methodologies allow clinicians to investigate diseases at the molecular level, enabling the identification of the most appropriate treatment strategies and ultimately improving patient outcomes.

Furthermore, this Special Issue addresses the challenges and future directions in this rapidly evolving field, including the need for robust data integration, biomarker validation, and the development of innovative computational tools for interpreting data. Ultimately, "Gene Expression in Personalized Management of Diseases of Civilisation" underscores the potential of gene expression analysis to revolutionize healthcare, ushering in an era of precision medicine tailored to the genetic makeup of each individual patient across a spectrum of modern diseases.

Dr. Beniamin Oskar Grabarek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gene expression
  • personalized medicine
  • precision medicine
  • diseases of civilisation
  • genomic technologies
  • next-generation sequencing
  • microarray analysis
  • molecular markers
  • biomarker validation
  • data integration
  • computational tools
  • tailored therapies
  • cancer
  • cardiovascular diseases
  • diabetes
  • neurodegenerative diseases
  • precision oncology
  • genomic profiling
  • therapeutic response prediction
  • disease management

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

22 pages, 1136 KiB  
Review
Personalized Treatment Strategies via Integration of Gene Expression Biomarkers in Molecular Profiling of Laryngeal Cancer
by Antonino Maniaci, Giovanni Giurdanella, Carlos Chiesa Estomba, Simone Mauramati, Andy Bertolin, Marco Lionello, Miguel Mayo-Yanez, Paolo Boscolo Rizzo, Jerome R. Lechien and Mario Lentini
J. Pers. Med. 2024, 14(10), 1048; https://doi.org/10.3390/jpm14101048 - 10 Oct 2024
Viewed by 1559
Abstract
Laryngeal cancer poses a substantial challenge in head and neck oncology, and there is a growing focus on customized medicine techniques. The present state of gene expression indicators in laryngeal cancer and their potential to inform tailored therapy choices are thoroughly examined in [...] Read more.
Laryngeal cancer poses a substantial challenge in head and neck oncology, and there is a growing focus on customized medicine techniques. The present state of gene expression indicators in laryngeal cancer and their potential to inform tailored therapy choices are thoroughly examined in this review. We examine significant molecular changes, such as TP53, CDKN2A, PIK3CA, and NOTCH1 mutations, which have been identified as important participants in the development of laryngeal cancer. The study investigates the predictive and prognostic significance of these genetic markers in addition to the function of epigenetic changes such as the methylation of the MGMT promoter. We also go over the importance of cancer stem cell-related gene expression patterns, specifically CD44 and ALDH1A1 expression, in therapy resistance and disease progression. The review focuses on indicators, including PD-L1, CTLA-4, and tumor mutational burden (TMB) in predicting immunotherapy responses, highlighting recent developments in our understanding of the intricate interactions between tumor genetics and the immune milieu. We also investigate the potential for improving prognosis accuracy and treatment selection by the integration of multi-gene expression panels with clinicopathological variables. The necessity for uniform testing and interpretation techniques is one of the difficulties, in implementing these molecular insights into clinical practice, that are discussed. This review seeks to provide a comprehensive framework for promoting personalized cancer therapy by combining the most recent data on gene expression profiling in laryngeal cancer. Molecularly guided treatment options may enhance patient outcomes. Full article
Show Figures

Figure 1

Back to TopTop