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Mechanism of Endocrine and Metabolic Diseases
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Mechanism of Endocrine and Metabolic Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 8978

Special Issue Editors

Dr. Teodora-Gabriela Alexescu

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Guest Editor
Internal Medicine Department, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Interests: biomarkers; cardiometabolic disease; nutrition; obesity; metabolic disorders; nutrigenetics
Special Issues, Collections and Topics in MDPI journals
Dr. Adela Viviana Sitar-Tăut

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Guest Editor
Internal Medicine Departament, Rehabilitation Cardiology Discipline, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania
Interests: cardiology; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The integration of different mechanisms of production and evolution of endocrine and metabolic diseases with modern theories of correct nutrition, nutrigenomics and nanoparticles can lead to the understanding of various cardiovascular, endocrine and metabolic pathologies. This Special Issue of the Journal of Personalized Medicine aims to highlight the current state of the science and showcase some of the latest findings in the field of endocrine and metabolic diseases. The scientific advances in the field of nutrition, nutrigenomics and nanoparticles will continue to pave the path towards personalized nutrition for optimal health and wellness. Original articles and reviews highlighting the mechanism and treatment for endocrine and metabolic diseases as well as personalized medicine are welcome.

Dr. Teodora-Gabriela Alexescu
Dr. Adela Viviana Sitar-Tăut
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • cardiometabolic disease
  • nutrition
  • obesity
  • metabolic disorders
  • nutrigenetics
  • nanoparticles

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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11 pages, 1864 KiB  
Article
Non-Pharmacological Intervention for Personalizing Sleep Quality through Gentle Rocking Motion
by Damiana-Maria Vulturar, Liviu-Ștefan Moacă, Ioana Maria Chețan, Ștefan Cristian Vesa, Teodora-Gabriela Alexescu, Cristina Grigorescu, Antigona Carmen Trofor, Mirela-Anca Stoia, Alexandra Floriana Nemes and Doina-Adina Todea
J. Pers. Med. 2024, 14(2), 218; https://doi.org/10.3390/jpm14020218 - 19 Feb 2024
Viewed by 1749
Abstract
Introduction: Achieving restorative sleep is crucial for overall well-being, yet sleep difficulties affect a substantial portion of the adult population. Sleep disturbances are associated with diminished quality of life, physical complaints, cognitive impairment, and emotional regulation challenges. Objective: This study explores the influence [...] Read more.
Introduction: Achieving restorative sleep is crucial for overall well-being, yet sleep difficulties affect a substantial portion of the adult population. Sleep disturbances are associated with diminished quality of life, physical complaints, cognitive impairment, and emotional regulation challenges. Objective: This study explores the influence of an innovative experimental bed designed to generate rocking motions on sleep parameters. Methods: A prospective observational study enrolled 60 adult participants, assessing their sleep on a regular stationary bed and the Inoveris bed, providing gentle rocking movements. Polysomnography was conducted, recording electroencephalography, electrooculogram, electromyogram, respiratory effort, and other parameters. Results: The rocking bed significantly increased total sleep time (TST) and reduced N1 sleep stage duration (p < 0.001). Participants also experienced a quicker transition to the N2 sleep stage (p = 0.01), indicative of a faster shift from wakefulness to deeper sleep. Additionally, rocking led to a higher percentage of N1 sleep stages (p = 0.01) and a significant increase in N3 sleep stage duration (p = 0.004). While some results lacked statistical significance, notable trends in the rocking bed group have clinical relevance, consistently improving sleep parameters, including increased TST. The rocking bed also showed a trend towards higher sleep efficiency (SE) and sleep duration percentage, hinting at a potential overall enhancement in sleep quality. Conclusion: This study contributes valuable insights into the potential benefits of rocking motions on sleep architecture. Despite variations in outcomes across studies, our results underscore the potential of rocking beds as a non-pharmacological intervention for enhancing sleep quality. Notable improvements in total sleep time (TST), N1 sleep stage reduction, and accelerated transitions to deeper sleep stages highlight the clinical relevance of rocking interventions. Further research, collaboration, and addressing the identified limitations will advance our understanding of the therapeutic applications of rocking motions in sleep science. Full article
(This article belongs to the Special Issue Mechanism of Endocrine and Metabolic Diseases)
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Review

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11 pages, 595 KiB  
Review
From Sweet to Sour: SGLT-2-Inhibitor-Induced Euglycemic Diabetic Ketoacidosis
by Andrijana Koceva and Nika Aleksandra Kravos Tramšek
J. Pers. Med. 2024, 14(7), 665; https://doi.org/10.3390/jpm14070665 - 21 Jun 2024
Viewed by 3823
Abstract
Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are highly selective, effective, and generally well-tolerated antihyperglycemic agents targeting the SGLT-2 transmembrane protein. Despite being primarily registered for diabetes treatment, due to their cardiorenal protective properties, SGLT-2 inhibitors caused a paradigm shift in the treatment of other [...] Read more.
Sodium–glucose cotransporter 2 (SGLT-2) inhibitors are highly selective, effective, and generally well-tolerated antihyperglycemic agents targeting the SGLT-2 transmembrane protein. Despite being primarily registered for diabetes treatment, due to their cardiorenal protective properties, SGLT-2 inhibitors caused a paradigm shift in the treatment of other diseases on the cardiorenal spectrum, becoming a fundamental part of heart failure and chronic kidney disease management. With their rapidly increasing use, there are also increased reports of a rare, often under-recognised and potentially deadly side effect, SGLT-2-inhibitor-induced euglycemic diabetic ketoacidosis (EDKA). The primary pathophysiological process behind its multifactorial aetiology comprises glucosuria and osmotic diuresis, which produce a significant carbohydrate deficit, leading to an increase in the glucagon–insulin ratio, thus resulting in accelerated ketogenesis. Although EDKA has a similar clinical presentation as diabetic ketoacidosis (DKA), the absence of the high glucose levels typically expected for DKA and the presence of urine ketone reabsorption contribute to a significant delay in its recognition and timely diagnosis. Given the broad use of SGLT-2 inhibitors, increased awareness, early recognition, and prompt identification of precipitating factors are essential. In this narrative review, we comprehensively explore the pathophysiological mechanisms of SGLT-2-inhibitor-induced EDKA, analyse its clinical manifestation, and identify the most common triggers for its development. We also discuss EDKA management and preventive strategies. Full article
(This article belongs to the Special Issue Mechanism of Endocrine and Metabolic Diseases)
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44 pages, 1384 KiB  
Review
Personalizing Nutrition Strategies: Bridging Research and Public Health
by Vicente Javier Clemente-Suárez, Helia Carmen Peris-Ramos, Laura Redondo-Flórez, Ana Isabel Beltrán-Velasco, Alexandra Martín-Rodríguez, Susana David-Fernandez, Rodrigo Yáñez-Sepúlveda and José Francisco Tornero-Aguilera
J. Pers. Med. 2024, 14(3), 305; https://doi.org/10.3390/jpm14030305 - 13 Mar 2024
Cited by 6 | Viewed by 2995
Abstract
In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat to the health of the global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s health and well-being. For this [...] Read more.
In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat to the health of the global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s health and well-being. For this reason, it is interesting to study dietary patterns, since the human diet is a complex mixture of macronutrients, micronutrients, and bioactive compounds, and can modulate multiple physiological processes, including immune function, the metabolism, and inflammation. To ensure that the data we acquired were current and relevant, we searched primary and secondary sources, including scientific journals, bibliographic indexes, and databases in the last 15 years with the most relevant articles. After this search, we observed that all the recent research on NCDs suggests that diet is a critical factor in shaping an individual’s health outcomes. Thus, cardiovascular, metabolic, mental, dental, and visual health depends largely on the intake, habits and patterns, and nutritional behaviors. A diet high in processed and refined foods, added sugars, and saturated fats can increase the risk of developing chronic diseases. On the other hand, a diet rich in whole, nutrient-dense foods, such as vegetables, fruits, nuts, legumes, and a high adherence to Mediterranean diet can improve health’s people. Full article
(This article belongs to the Special Issue Mechanism of Endocrine and Metabolic Diseases)
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