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Psychiatry: Emerging Clinical Research in Personalized Medicine
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Psychiatry: Emerging Clinical Research in Personalized Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2914

Special Issue Editors

Dr. Joanna Rog

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Guest Editor
Laboratory of Human Metabolism Research, Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 02-787 Warsaw, Poland
Interests: inflammation; nutrition; gut-brain axis; gut microbiome; gut permeability; nutritional psychiatry; statistical analysis; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Baland Jalal

E-Mail Website
Guest Editor
Department of Psychiatry, University of Cambridge, Downing St, Cambridge CB2 3EB, UK
Interests: neuropsychiatry; technology; personalized medicine; smartphones; sleep paralysis
Prof. Dr. Hanna Karakuła-Juchnowicz

E-Mail Website
Guest Editor
1st Department of Psychiatry, Psychotherapy and Early Intervention Medical University of Lublin, Gluska Street 1, 20-439 Lublin, Poland
Interests: schizophrenia; bipolar disorder

Special Issue Information

Dear Colleagues,

Treatment strategies for mental health issues are concerned with diagnosis and do not always consider the multi-dimensional mechanisms involved in their pathophysiology. The heterogeneity of psychiatric disorders determines the need for targeted therapies for specific subtypes of the disease. This approach, including genetic factors, tailored assessments, and specific strategies for their combination, will allow for improved treatment efficacy, especially in non-responders. In this Special Issue of the Journal of Personalized Medicine, we invite researchers to submit original papers (especially randomized clinical trials), protocols of studies, methods, systematic reviews, and meta-analyses that concentrate on clinical research in personalized psychiatry. Manuscripts focused on diagnosis and pharmacological and non-pharmacological treatment, including genetic typing, biomarkers, biofluids, biofluids concentrations of medications, and innovative treatment (especially concerning lifestyle) methods are welcome to be submitted to this Special Issue.

Dr. Joanna Rog
Dr. Baland Jalal
Prof. Dr. Hanna Karakuła-Juchnowicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psychiatric disorders
  • personalized psychiatry
  • randomized clinical trials
  • interventional studies
  • lifestyle psychiatry
  • nutritional psychiatry
  • biomarkers
  • psychiatric disorders predictors
  • genetic
  • epigenetic
  • inflammation
  • metabolomics

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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21 pages, 1108 KiB  
Article
The Path from Personality to Anxiety and Depression Is Mediated by Cognition in Multiple Sclerosis
by Alina Schenk, Cosmin Octavian Popa, Cristiana Manuela Cojocaru, Ștefan Marian, Smaranda Maier and Rodica Bălașa
J. Pers. Med. 2024, 14(7), 682; https://doi.org/10.3390/jpm14070682 - 25 Jun 2024
Cited by 1 | Viewed by 1334
Abstract
Background: Multiple sclerosis (MS) is a neurodegenerative immunological disease causing significant impairment in all life areas. Therefore, personality changes are observed and associated with higher prevalence of depression and anxiety disorders. Considering this relationship, we hypothesized that clinical symptoms and personality disorders are [...] Read more.
Background: Multiple sclerosis (MS) is a neurodegenerative immunological disease causing significant impairment in all life areas. Therefore, personality changes are observed and associated with higher prevalence of depression and anxiety disorders. Considering this relationship, we hypothesized that clinical symptoms and personality disorders are more prevalent in MS and that dysfunctional psychological mechanisms mediate the path from personality disorders to clinical symptoms. Methods: The study sample consisted of 43 patients with MS (age M = 41.9, SD = 11.5) and 31 controls (age M = 39.8, SD = 10.3). Measures of personality, anxiety, depression, fatigue, health status, and dysfunctional psychological mechanisms were conducted. Results: The prevalence of clinical symptoms was increased in MS patients as compared to controls. Also, dependent and schizoid personality traits (PTs) were observed in the patient sample. Negative automatic thoughts (NATs) were found to mediate the association between dependent PT and clinical symptoms. Along with schizoid PT, all dysfunctional psychological mechanisms impacted clinical symptoms. Discussion: The results of our research are in line with previous studies showing that anxiety, depression, and dysfunctional personality traits are more prevalent in MS as compared to controls. Conclusions: PTs and dysfunctional psychological mechanisms predicted depression, anxiety, fatigue, and health status in MS patients. Cognition acts as a strong mediator between PTs and psychopathology in MS. Hence, integrative personalized psychological treatment is recommended to improve the quality of care in MS. Full article
(This article belongs to the Special Issue Psychiatry: Emerging Clinical Research in Personalized Medicine)
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13 pages, 565 KiB  
Article
The Relationship between Sense of Presence, Emotional Response, and Clinical Outcomes in Virtual Reality-Based Therapy for Treatment-Resistant Schizophrenia: An Exploratory Correlational Study
by Elischa Augustin, Mélissa Beaudoin, Sabrina Giguère, Hind Ziady, Kingsada Phraxayavong and Alexandre Dumais
J. Pers. Med. 2024, 14(6), 614; https://doi.org/10.3390/jpm14060614 - 8 Jun 2024
Viewed by 1122
Abstract
Avatar therapy (AT) is a novel virtual reality-based psychotherapy that has been developed to treat auditory verbal hallucinations (AVH) in treatment-resistant schizophrenia. Various psychotherapeutic components, such as emotions and sense of presence, could contribute to clinical outcomes. However, the interplay between sense of [...] Read more.
Avatar therapy (AT) is a novel virtual reality-based psychotherapy that has been developed to treat auditory verbal hallucinations (AVH) in treatment-resistant schizophrenia. Various psychotherapeutic components, such as emotions and sense of presence, could contribute to clinical outcomes. However, the interplay between sense of presence, emotions, and clinical response has seldom been investigated. This study aimed to explore the relations between sense of presence, emotions, and clinical outcomes in AT. To conduct this investigation, data from previous and ongoing AT trials were used. Sense of presence and emotions were assessed using standardized questionnaires. AVH were evaluated using the Psychotic Symptom Rating Scales. While sense of presence was positively associated with positive emotions such as control and serenity, no significant associations were found for negative emotions. Moreover, a higher level of sense of presence was associated with a bigger decrease in AVH. Overall, positive emotions seem to be associated with sense of presence in AT. Sense of presence also seems to be involved in the therapeutic outcome, thereby suggesting that this could be an important component related to clinical response. More studies are needed to confirm these trends, which could be generalized to other virtual reality-based psychotherapies. Full article
(This article belongs to the Special Issue Psychiatry: Emerging Clinical Research in Personalized Medicine)
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