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Personalized Therapy and Clinical Outcomes for Chronic Pain
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Personalized Therapy and Clinical Outcomes for Chronic Pain

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (20 January 2024) | Viewed by 8237

Special Issue Editor

Dr. Federica Galli

E-Mail Website
Guest Editor
Department of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University of Rome, 00185 Rome, Italy
Interests: psychosomatic; chronic pain; cardiovascular disease; headache
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pain (CP) is a substantial healthcare challenge with prevalence rates between 11% and 40% and considerable economic costs. Recently, the International Association for the Study of Pain (IASP 2017) has proposed that three subtypes of CP may be differentiated based on unique causal mechanisms: 1. nociceptive, which is associated with an ongoing input from real or threatened tissue injury; 2. neuropathic, caused by injury or disease affecting the peripheral or central nervous system; 3. nociplastic, which is a new descriptor of CP and includes conditions that arise from altered nociception despite no clear evidence of actual or threatened tissue damage. This is a new way of describing somatoform painful conditions, originating from altered central-nervous pathways (e.g., central sensitization) and with the important involvement of clinical psychological factors. CP affects relationships and self-esteem and is associated with higher divorce and suicide rates, and an increased risk of substance abuse, psychopathology, and risk of medication overuse. Pain is a dynamic consequence of a host of biological, psychological, and social factors; hence, guidelines have recommended interdisciplinary treatment, which ideally makes use of a personalized approach. Regardless of its causes, CP calls to a multidisciplinary approach to relive its burden in patients. The new era of personalized medicine calls to the importance of tailoring medical and psychological interventions on individual patient characteristics. The Special Issue will aim to collect contributions on personalized therapy and clinical outcomes for any kind of CP.

Dr. Federica Galli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic pain
  • drug therapy
  • non-drug therapy
  • personalized medicine
  • clinical psychology

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Published Papers (4 papers)

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Editorial

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2 pages, 173 KiB  
Editorial
Understanding Nociplastic Pain: Building a Bridge between Clinical Psychology and Medicine
by Federica Galli
J. Pers. Med. 2023, 13(2), 310; https://doi.org/10.3390/jpm13020310 - 10 Feb 2023
Cited by 4 | Viewed by 2048
Abstract
Chronic pain (CP), defined as pain lasting more than three months, is a significant healthcare challenge with considerable economic costs [...] Full article
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Chronic Pain)

Research

Jump to: Editorial, Other

14 pages, 772 KiB  
Article
Post-Operative Thoracic Epidural Analgesia and Incidence of Major Complications according to Specific Safety Standardized Documentation: A Large Retrospective Dual Center Experience
by Despoina G. Sarridou, Sophia Anastasia Mouratoglou, Jeremy B. Mitchell, Felicia Cox, Afroditi Boutou, Maria Braoudaki, George I. Lambrou, Maria Konstantinidou, Helena Argiriadou and Christopher P. R. Walker
J. Pers. Med. 2023, 13(12), 1672; https://doi.org/10.3390/jpm13121672 - 29 Nov 2023
Cited by 3 | Viewed by 1781
Abstract
(1) Background: Thoracic epidural analgesia is considered the gold standard in post-operative pain management following thoracic surgery. This study was designed to explore the safety of thoracic epidural analgesia and to quantify the incidence of its post-operative complications and side effects in patients [...] Read more.
(1) Background: Thoracic epidural analgesia is considered the gold standard in post-operative pain management following thoracic surgery. This study was designed to explore the safety of thoracic epidural analgesia and to quantify the incidence of its post-operative complications and side effects in patients undergoing thoracotomy for major surgery, such as resection of lung malignancies and lung transplantation. (2) Methods: This is a retrospective, dual-center observational study including patients that underwent major thoracic surgery including lung transplantation and received concurrent placement of thoracic epidural catheters for post-operative analgesia. An electronic system of referral and documentation of complications was used, and information was retrieved from our electronic critical care charting system. (3) Results: In total, 1145 patients were included in the study. None of the patients suffered any major complication, including hematoma, abscess, or permanent nerve damage. (4) Conclusions: the present study showed that in experienced centers, post-operative epidural analgesia in patients with thoracotomy is a safe technique, manifesting minimal, none-serious complications. Full article
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Chronic Pain)
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15 pages, 3672 KiB  
Article
Needs and Demands for eHealth Pain Management Interventions in Chronic Pain Patients
by Paula Stoppok, Anna-Lena Frewer, Adam Schweda, Sheila Geiger, Eva-Maria Skoda, Diana Müßgens, Ulrike Bingel, Martin Teufel and Alexander Bäuerle
J. Pers. Med. 2023, 13(4), 675; https://doi.org/10.3390/jpm13040675 - 17 Apr 2023
Cited by 4 | Viewed by 1945
Abstract
Although chronic pain is a global health problem, the current care situation is often inadequate. eHealth offers many advantages as an additional option for treating chronic pain. Yet, an intervention’s efficacy can only be fully exhausted if patients intend to use it. This [...] Read more.
Although chronic pain is a global health problem, the current care situation is often inadequate. eHealth offers many advantages as an additional option for treating chronic pain. Yet, an intervention’s efficacy can only be fully exhausted if patients intend to use it. This study aims to identify the needs and demands of patients with chronic pain regarding intervention concepts and frameworks to develop specifically tailored eHealth pain management interventions. A cross-sectional study was conducted, including 338 individuals with chronic pain. Within the cohort, a distinction between a high- and a low-burden group was made. Respondents generally preferred a permanently accompanying mobile app, but the preferred content varied with group. According to the majority, interventions should be made available on smartphones, offer sessions once per week with a duration from 10 to 30 min, and be recommended by experts. These results can provide the basis for future eHealth pain management interventions tailored to the patients’ needs and demands. Full article
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Chronic Pain)
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Other

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14 pages, 817 KiB  
Systematic Review
Mind–Body Training: A Plausible Strategy against Osteomuscular Chronic Pain—A Systematic Review with Meta-Analysis
by Julia Gámez-Iruela, Agustín Aibar-Almazán, Diego Fernando Afanador-Restrepo, Yolanda Castellote-Caballero, Fidel Hita-Contreras, María del Carmen Carcelén-Fraile and Ana María González-Martín
J. Pers. Med. 2024, 14(2), 200; https://doi.org/10.3390/jpm14020200 - 11 Feb 2024
Cited by 1 | Viewed by 1632
Abstract
(1) Background: Chronic pain, which affects more than one in five adults worldwide, has a negative impact on the quality of life, limiting daily activities and generating absences from work. The aim of the present review is to analyze the efficacy of mind–body [...] Read more.
(1) Background: Chronic pain, which affects more than one in five adults worldwide, has a negative impact on the quality of life, limiting daily activities and generating absences from work. The aim of the present review is to analyze the efficacy of mind–body therapies as therapeutic strategies for patients with chronic pain. (2) Methods: A systematic review with a meta-analysis was carried out, searching PubMed, Scopus, and Web of Science databases using specific keywords. We selected studies that included mind–body therapies as the primary intervention for older adults with chronic pain. The methodological quality of the articles was assessed using the PEDro scale. (3) Results: Of the 861 studies identified, 11 were included in this review, all of which employed different mind–body therapies as an intervention. The selected studies measured chronic pain as the main variable. (4) Conclusions: This review highlights the value of mind–body exercises in reducing chronic pain in older adults, suggesting their integration as a non-pharmacological therapeutic alternative that improves the quality of life, promoting a holistic approach to pain management. Full article
(This article belongs to the Special Issue Personalized Therapy and Clinical Outcomes for Chronic Pain)
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