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Gynecologic Oncology: From Molecular Mechanisms to Personalized Treatment
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Gynecologic Oncology: From Molecular Mechanisms to Personalized Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 680

Special Issue Editors

Dr. Iason Psilopatis

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, University Erlangen, Universitaetsstrasse 21–23, 91054 Erlangen, Germany
Interests: gynecology; oncology; obstetrics; breast; uterus; endometriosis; fibroid; ovarian
Dr. Christos Damaskos

E-Mail Website
Guest Editor
Renal Transplantation Unit, Laiko General Hospital, 11527 Athens, Greece
Interests: surgery; transplantation; surgical oncology; oncology; experimental surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecologic cancers pose significant challenges to women's health globally, necessitating a nuanced understanding of their molecular underpinnings for effective personalized treatment strategies. This Special Issue delves into the latest research and innovations in gynecologic oncology, spanning molecular mechanisms, diagnostic modalities, and therapeutic interventions. From elucidating the intricate signaling pathways driving tumorigenesis to exploring novel biomarkers and targeted therapies, these contributions highlight the diverse facets of gynecologic malignancies. Moreover, the emphasis is placed on integrating cutting-edge technologies, such as genomics, proteomics, and immunotherapy, within clinical practice to tailor treatment approaches based on individual patients’ profiles. By fostering an interdisciplinary dialogue and showcasing advancements at the intersection of basic science and clinical care, this Special Issue endeavors to propel the field of gynecologic oncology towards more precise and personalized treatments, ultimately improving patients’ outcomes and quality of life.

Dr. Iason Psilopatis
Dr. Christos Damaskos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ovarian cancer
  • breast cancer
  • endometrial cancer
  • cervical cancer
  • molecular pathway
  • epigenetics
  • personalized treatment
  • targeted therapy

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Published Papers (1 paper)

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22 pages, 951 KiB  
Systematic Review
Pulmonary Endometriosis: A Systematic Review
by Konstantinos Nikolettos, Alexandros Patsouras, Sonia Kotanidou, Nikolaos Garmpis, Iason Psilopatis, Anna Garmpi, Eleni I. Effraimidou, Angelos Daniilidis, Dimitrios Dimitroulis, Nikos Nikolettos, Panagiotis Tsikouras, Angeliki Gerede, Dimitrios Papoutsas, Emmanuel Kontomanolis and Christos Damaskos
J. Pers. Med. 2024, 14(11), 1085; https://doi.org/10.3390/jpm14111085 - 31 Oct 2024
Viewed by 418
Abstract
Background/Objectives: Endometriosis is characterized by the presence of ectopic endometrial-like glands and stroma outside the endometrial cavity, which mainly occurs in the pelvic cavity. Pulmonary endometriosis, or thoracic endometriosis syndrome (TES), describes the rare presence of endometrial-like cells in the thoracic cavity [...] Read more.
Background/Objectives: Endometriosis is characterized by the presence of ectopic endometrial-like glands and stroma outside the endometrial cavity, which mainly occurs in the pelvic cavity. Pulmonary endometriosis, or thoracic endometriosis syndrome (TES), describes the rare presence of endometrial-like cells in the thoracic cavity and includes catamenial pneumothorax, catamenial hemothorax, hemoptysis, and lung nodules. Our aim is to summarize the results of all reported cases of TES. Methods: Extensive research was conducted through MEDLINE/PUBMED using the keywords “thoracic endometriosis”, “thoracic endometriosis syndrome”, “catamenial pneumothorax”, “catamenial hemoptysis”, and “TES”. Following PRISMA guidelines, all published cases of TES between January 1950 and March 2024 were included. A systematic review of 202 studies in English, including 592 patients, was performed. Results: The median age of women with TES is 33.8 years old. The most common clinical presentation is catamenial pneumothorax (68.4%), while lesions are mainly found in the right lung unilaterally (79.9%). Chest computed tomography (CT) was used alone or after an X-ray to determine the pathological findings. Ground-glass opacity nodules and cystic lesions represent the most common finding in CT, while pneumothorax is the most common finding in X-rays. Video-assisted thoracoscopic surgery (VATS) is the main therapeutic approach, usually in combination with hormonal therapy, including GnRH analogues, progestins, androgens, or combined oral contraceptives. Hormonal therapy was also administered as monotherapy. Symptom recurrence was reported in 10.1% of all cases after the treatment. Conclusions: High clinical awareness and a multidisciplinary approach are necessary for the best clinical outcome for TES patients. More studies are required to extract safer conclusions. Full article
(This article belongs to the Special Issue Gynecologic Oncology: From Molecular Mechanisms to Personalized Treatment)
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