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Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and...
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Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 4687

Special Issue Editor

Dr. Marco Di Carlo

E-Mail Website
Guest Editor
Rheumatology Clinic, Ospedale “Carlo Urbani”, Università Politecnica delle Marche, Jesi (Ancona), Italy
Interests: inflammatory arthritides; musculoskeletal pain; fibromyalgia; imaging; clinimetry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Psoriatic arthritis represents a condition whose clinical expressiveness can be extremely heterogeneous. The wide clinical variability often results in diagnostic pitfalls, hence the need for a personalized approach on multiple fronts: from the use of sophisticated imaging techniques, to clinimetry according to prevalent manifestations, to treatment. The high prevalence of coexisting fibromyalgia can complicate the evaluation of these patients.

With these issues as our focus, I am delighted to invite you to contribute to this Special Issue, aimed at emphasizing the need for personalization in the setting of psoriatic arthritis.   

Areas covered by this Special Issue (both original contributions and literature reviews are welcome) include, but are not limited to:

  • The use of imaging techniques in the diagnosis of psoriatic arthritis and its major manifestations (synovitis, enthesitis, dactylitis, axial involvement);
  • The clinimetric approach with reference to inflammatory manifestations and disease impact on quality of life;
  • The burden of comorbidities, including fibromyalgia among them;
  • Therapeutic personalization.

I look forward to your contribution.

Best regards,

Dr. Marco Di Carlo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • psoriatic arthritis
  • imaging
  • synovitis
  • dactylitis
  • enthesitis
  • comorbidities
  • clinimetry
  • biologic DMARDs
  • targeted synthetic DMARDs

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Published Papers (3 papers)

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Research

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9 pages, 424 KiB  
Article
Ultrasonographic Synovitis Is Associated with the Development of Joint Destruction in Patients with Psoriatic Arthritis
by Yutaro Yamada, Kentaro Inui, Koji Mandai, Kenji Mamoto, Tatsuya Koike, Chiharu Tateishi, Daisuke Tsuruta and Tadashi Okano
J. Pers. Med. 2024, 14(6), 630; https://doi.org/10.3390/jpm14060630 - 13 Jun 2024
Viewed by 769
Abstract
Background: Psoriatic arthritis (PsA) is characterized by enthesitis. As persistent inflammation around joints results in bone and cartilage destruction and physical impairment, a detailed assessment of inflammation is essential. We previously reported the difference between clinical assessment (tenderness) and ultrasound (US) assessment (inflammation) [...] Read more.
Background: Psoriatic arthritis (PsA) is characterized by enthesitis. As persistent inflammation around joints results in bone and cartilage destruction and physical impairment, a detailed assessment of inflammation is essential. We previously reported the difference between clinical assessment (tenderness) and ultrasound (US) assessment (inflammation) of entheses. Herein, we investigated whether clinical or US assessment of joints and entheses can predict the progression of joint destruction in Japanese patients with PsA. Methods: Thirty joints and 14 entheses in 47 patients were assessed using US and clinical examination. The US greyscale (GS) and power Doppler (PD) scores at the ultrasonographic synovitis, the US active enthesitis count, and the clinical tender joint/entheses count were assessed. Additionally, the yearly radiographic progression of the Sharp–van der Heijde scoring method for PsA was assessed. Their correlations were investigated. Results: About half of the patients with PsA experienced joint destruction during a follow-up period of 20.4 months. Progression of joint destruction in patients with PsA only correlated with joint GS and PD scores, reflecting the severity of ultrasonographic synovitis, not with the tender joint/entheses count. Conclusions: US examinations are essential for preventing joint destruction and physical impairment in patients with PsA. Full article
(This article belongs to the Special Issue Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment)
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15 pages, 1417 KiB  
Article
The Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts): Measurement Properties of a New Multidimensional Composite Tool for the Quick Assessment of the Overall Health Status in Psoriatic Arthritis
by Fausto Salaffi, Marina Carotti, Sonia Farah and Marco Di Carlo
J. Pers. Med. 2023, 13(7), 1153; https://doi.org/10.3390/jpm13071153 - 18 Jul 2023
Viewed by 1891
Abstract
Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in [...] Read more.
Background: Psoriatic arthritis (PsA) is a heterogeneous condition that is difficult to assess. The goal of this research was to evaluate the clinimetric properties of the Psoriatic Arthritis 5-Thermometer Scales (PsA-5Ts), a new patient-reported outcome (PRO) to measure the overall health status in PsA patients. Methods: The PsA-5Ts were compared to composite measures of disease activity (DAPSA, PASDAS, CPDAI) and PROs (PsAID-12 and SF-36). The convergent validity was assessed through the Spearman’s correlation coefficient and the discriminant validity through the receiver operating characteristic (ROC) curve analysis, applying the Minimal Disease Activity (MDA) as an external criterion. Results: The cross-sectional assessment included 155 patients. Significant high correlations were observed when comparing PsA-5Ts to composite indices of disease activity and PROs (all at significance levels of p < 0.0001). The PsA-5Ts subscales were highly significantly different in terms of MDA status (all at p < 0.0001). The PsA-5Ts had good discriminant validity like that of the DAPSA, CPDAI, PASDAS, and PsAID-12, and better than that of the SF-36, with an area under the ROC curve of 0.944 (65% CI 0.895–0.974). Conclusions: The PsA-5Ts are an easy-to-use PRO that can be integrated with disease activity indices in the assessment of PsA in daily clinical practice. Full article
(This article belongs to the Special Issue Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment)
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Review

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14 pages, 2258 KiB  
Review
Ultrasonographic Insights into Peripheral Psoriatic Arthritis: Updates in Diagnosis and Monitoring
by Karina Rossi Bonfiglioli, Fernanda Oliveira de Andrade Lopes, Letícia Queiroga de Figueiredo, Luis Fernando Fernandes Ferrari and Lissiane Guedes
J. Pers. Med. 2024, 14(6), 550; https://doi.org/10.3390/jpm14060550 - 22 May 2024
Cited by 1 | Viewed by 1411
Abstract
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis, characterized by heterogeneous clinical manifestations and variable disease progression. Ultrasonography has emerged as a valuable tool in the diagnosis and monitoring of PsA, providing real-time visualization of joint and soft tissue abnormalities. [...] Read more.
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis, characterized by heterogeneous clinical manifestations and variable disease progression. Ultrasonography has emerged as a valuable tool in the diagnosis and monitoring of PsA, providing real-time visualization of joint and soft tissue abnormalities. This review highlights recent advancements in ultrasonographic techniques for the assessment of PsA, including the identification of typical features, the role of power Doppler imaging in detecting active inflammation, and the potential of ultrasound for guiding treatment decisions. Additionally, we discuss the utility of ultrasound in assessing treatment response and monitoring disease progression in patients with PsA, with a focus on novel imaging modalities. By elucidating the evolving role of ultrasonography in PsA management, this article aims to enhance clinicians’ understanding of its utility in facilitating early diagnosis, optimizing treatment strategies, and improving patient outcomes. Full article
(This article belongs to the Special Issue Psoriatic Arthritis and the Need to Personalize Diagnosis, Clinimetry, and Treatment)
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