Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 8882

Special Issue Editor


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Guest Editor
1. Department of Neurosurgery, Vitaz, Sint-Niklaas, Belgium
2. Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
Interests: surgery of the degenerated spine and surgical treatment of Trigeminal neuralgia

Special Issue Information

Dear Colleagues,

Chronic low back pain (CLBP) is the most frequently reported cause of years lived with disability. Due to the complicated structure and function of the lumbar spine, it is hard to provide a correct diagnosis (type and cause of the pain) and consequently establish a treatment plan. In general, three categories of presumptive pain mechanisms can be defined: non-degenerative CLBP (trauma, tumor, inflammation, and infection); degenerative CLBP (non-specific CLBP); and CLBP of unknown origin, where medical imaging cannot explain the presenting symptoms.

Degenerative CLBP can originate from the discs, facet joints (or both), ligaments, regional or global disorders of spinal balance and muscles, tendons, nervous tissue, facet, and sacroiliac joint degeneration. The diagnosis mainly relies on medical history, clinical examination, medical imaging, and the consideration of differential diagnoses. In most cases, no clear pain source can be identified.

There is evidence that pharmacological treatment is effective for the management of acute LBP, while chronic symptoms often require a multidisciplinary approach, including rehabilitation, physical and psychological treatment, minimal interventional pain management, and eventually surgery. The treatment of CLBP is ideally performed in a multidisciplinary context for patient assessment and the establishment of a treatment plan.

In this Special Issue, we will focus on degenerative CLBP. In the diagnostic work, we will try to identify the structures that cause the pain. For each diagnosis, the potential treatment schedule will be described. The selection of interventional pain management procedures and surgery will be discussed, providing a balance between expected outcomes and potential side effects and complications.

Prof. Dr. Erik Van de Kelft
Guest Editor

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Keywords

  • chronic low back
  • musculoskeletal pain
  • conservative treatment
  • interventional treatment
  • spine surgery

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Published Papers (4 papers)

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Research

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11 pages, 2771 KiB  
Article
Outcomes of Mulligan Concept Applications in Obese Individuals with Chronic Mechanical Low Back Pain: A Randomized Controlled Trial
by Muhammed Safa Cankaya and Omer Osman Pala
Life 2024, 14(6), 754; https://doi.org/10.3390/life14060754 - 13 Jun 2024
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Abstract
Background: Various treatment modalities have been employed for mechanical low back pain (MLBP), but evidence of their efficacy varies greatly. Objectıve: This randomized controlled trial aimed to assess the outcomes of Mulligan concept applications, including sustained natural apophyseal glides (SNAGS) and natural apophyseal [...] Read more.
Background: Various treatment modalities have been employed for mechanical low back pain (MLBP), but evidence of their efficacy varies greatly. Objectıve: This randomized controlled trial aimed to assess the outcomes of Mulligan concept applications, including sustained natural apophyseal glides (SNAGS) and natural apophyseal glides (NAGS), in obese patients with MLBP. Methods: The study, conducted between January 2021 and June 2022 at a tertiary hospital, involved randomizing patients into two groups. Both groups underwent six sessions of stretching and strengthening exercises every other day. The Mulligan group received additional intervention with SNAG and NAGS techniques. Measurements were made regarding the Visual Analog Scale (VAS) score, Oswestry Disability Index (ODI) score and range of motion (ROM) for the patients’ MLBP level. Results: Post-interventions, both groups exhibited positive changes in flexion ROM, extension ROM, right and left rotation ROM, right and left lateral flexion ROM, VAS score, and ODI score compared to pre-intervention (p < 0.001 for both groups and variables). The Mulligan group showed a higher increase in ROM and a more significant decrease in VAS and ODI scores. Conclusıons: Mulligan mobilization techniques prove significantly beneficial for enhancing ROM in all directions, reducing pain levels, and alleviating disability in obese individuals with MLBP. Full article
(This article belongs to the Special Issue Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment)
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Review

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13 pages, 1297 KiB  
Review
Spinal Metastases of the Vertebrae: Three Main Categories of Pain
by Ruben Van den Brande, Charlotte Billiet, Marc Peeters and Erik Van de Kelft
Life 2024, 14(8), 988; https://doi.org/10.3390/life14080988 - 8 Aug 2024
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Abstract
Oncologic back pain, infection, inflammation, and trauma are the only specific etiologies of chronic low back pain (CLBP) in contrast to most patients who have non-specific CLBP. In oncologic patients developing CLBP, it is critically important to perform further investigation to exclude spinal [...] Read more.
Oncologic back pain, infection, inflammation, and trauma are the only specific etiologies of chronic low back pain (CLBP) in contrast to most patients who have non-specific CLBP. In oncologic patients developing CLBP, it is critically important to perform further investigation to exclude spinal metastases (SM).The incidence of cancer is increasing, with 15.7–30% developing SM. In the case of symptomatic SM, we can distinguish three main categories: tumor pain; mechanical pain due to instability, with or without pathologic fractures; and metastatic epidural spinal cord compression (MESCC) or radicular compression. Treatment of SM-related pain is dependent on these categories and consists of symptomatic treatment, target therapy to the bone, radiotherapy, systemic oncologic treatment, and surgery. The care for SM is a multidisciplinary concern, with rapid evolutions in all specialties involved. It is of primordial importance to incorporate the knowledge of specialists in all participating disciplines, such as oncology, radiotherapy, and spinal surgery, to determine the adequate treatment to preserve ambulatory function and quality of life while limiting the burden of treatment if possible. Awareness of potential SM is the first and most important step in the treatment of SM-related pain. Early diagnosis and timely treatment could prevent further deterioration. In this review, we explore the pathophysiology and symptomatology of SM and the treatment options for SM-related pain: tumor pain; mechanical pain due to instability, with or without pathologic fractures; and MESCC or radicular compression. Full article
(This article belongs to the Special Issue Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment)
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27 pages, 1617 KiB  
Review
Chronic Low Back Pain: History, Symptoms, Pain Mechanisms, and Treatment
by Tyler Farley, Jesse Stokke, Kush Goyal and Russell DeMicco
Life 2024, 14(7), 812; https://doi.org/10.3390/life14070812 - 27 Jun 2024
Viewed by 5242
Abstract
Chronic low back pain (cLBP) is the most frequently reported cause of years lived with disability. Identifying the anatomical structures or dysfunction contributing to patients’ symptoms is critical to guiding treatment. The etiology of back pain and differential diagnosis is often broad, ranging [...] Read more.
Chronic low back pain (cLBP) is the most frequently reported cause of years lived with disability. Identifying the anatomical structures or dysfunction contributing to patients’ symptoms is critical to guiding treatment. The etiology of back pain and differential diagnosis is often broad, ranging from non-degenerative cLBP (trauma, tumor, inflammation, infection, etc.) to degenerative (also described as nonspecific) cLBP. After eliminating suspicion for more insidious causes of cLBP, a thorough investigation can be conducted in an attempt to identify a source of degenerative cLBP. Degenerative cLBP can originate from many sources, and a detailed understanding of the structures potentially involved is invaluable for an accurate diagnosis. This review article aims to provide a broad overview of the utility of clinical history, physical exam findings, imaging findings, and diagnostic procedures in identifying the cause of patients’ cLBP. We provide a framework to help guide clinicians by dividing the structures into groups as follows: anterior vertebral column, posterior vertebral column, and extra-vertebral pain. For each condition listed, we touch on the treatment options that can be considered. Full article
(This article belongs to the Special Issue Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment)
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Other

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18 pages, 834 KiB  
Systematic Review
The Efficacy of the Smartphone App for the Self-Management of Low Back Pain: A Systematic Review and Assessment of Their Quality through the Mobile Application Rating Scale (MARS) in Italy
by Luca Scala, Gloria Giglioni, Luca Bertazzoni and Francesca Bonetti
Life 2024, 14(6), 760; https://doi.org/10.3390/life14060760 - 13 Jun 2024
Viewed by 1116
Abstract
Smartphone apps for self-management are valuable tools to help manage low back pain (LBP) patients. The purposes of this systematic review were to (a) summarize the available studies on the efficacy of smartphone apps for self-management of LBP and (b) identify free applications [...] Read more.
Smartphone apps for self-management are valuable tools to help manage low back pain (LBP) patients. The purposes of this systematic review were to (a) summarize the available studies on the efficacy of smartphone apps for self-management of LBP and (b) identify free applications available in Italy that offer strategies for LBP self-management and provide a qualitative assessment using the Mobile Application Rating Scale (MARS). According to the Prisma Checklist, six bibliographic databases were searched with the keywords ‘low back pain’, ‘mobile application’, ‘smartphone’, and ‘telemedicine’. In total, 852 records were screened, and 16 were included in the systematic review. Of the six RCTs included, four reported a statistically significant decrease in pain in favor of the app group, and two RCTs did not. Only in a non-RCT was there an increase in the disability score. In the application research conducted on mobile stores, we identified and rated 25 applications through MARS. The overall scores ranged from 1.93 to 3.92 for the IOS app and 1.73 to 4.25 for the Play Store app. The findings suggest that few apps meet satisfying quality, content, and functionality criteria for LBP self-management. Full article
(This article belongs to the Special Issue Chronic Low Back Pain: Symptoms, Pain Mechanisms and Treatment)
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