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Life
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Frontiers in Tissue Injury and Regeneration Repair
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Frontiers in Tissue Injury and Regeneration Repair

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 9023

Special Issue Editor

Dr. Zhaoliang Su

E-Mail Website
Guest Editor
School of Medicine, Jiangsu University, Zhenjiang 212013, China
Interests: macrophage; tissue regeneration; tissue repair; cardiac injury;
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue: Frontiers in tissue injury and regeneration/repair will collect the research articles or reviews about the injury mechanism of important human tissues and organs (for example, heart, liver, lung, etc.) and the functional remodeling process after injury, especially focusing on the immune microenvironment formed by immune cells such as macrophages, innate lymphoid cells, T cells and so on. Of course other immune cells or molecule-mediated damage and repair are also encouraged.

We invite suggestions for manuscripts to be included in this special issue. Please contact the editors before preparing the manuscript for a pre-arrangement of the topic.

Dr. Zhaoliang Su
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (4 papers)

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Research

14 pages, 3468 KiB  
Article
Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection
by Eugenia G. Kuznetsova, Lydia A. Salomatina, Olga M. Kuryleva, Lyudmila A. Kirsanova, Zalina Z. Gonikova, Alla O. Nikolskaya, Murat Yu. Shagidulin, Natalya P. Shmerko and Victor I. Sevastianov
Life 2023, 13(3), 658; https://doi.org/10.3390/life13030658 - 27 Feb 2023
Viewed by 1641
Abstract
Previously, the authors showed that the application of the aminodihydrophthalazinedione sodium (ADPS) immunomodulator transdermal therapeutic system (TTS) to laboratory animals provides bioavailability analogous to the intramuscular administration of this drug at the same dose. At the same time, its maximum blood concentration is [...] Read more.
Previously, the authors showed that the application of the aminodihydrophthalazinedione sodium (ADPS) immunomodulator transdermal therapeutic system (TTS) to laboratory animals provides bioavailability analogous to the intramuscular administration of this drug at the same dose. At the same time, its maximum blood concentration is significantly reduced, and the retention time of the drug in the body is increased more than 10-fold, which can contribute to prolonging the drug effect. The aim of the work was to identify a possible positive effect of the transdermal administration of the ADPS immunomodulator on reparative liver regeneration on an experimental model of extensive liver resection (ELR). It has been shown that at a period of 48 h after ELR, the percutaneous administration of the immunomodulator has a pronounced stimulating effect on the mitotic activity of rat liver cells; by 72 h after ELR, an accelerated rate of recovery of hepatic homeostasis in the body was observed in laboratory animals in groups with the application of the ADPS TTS versus the control group. Full article
(This article belongs to the Special Issue Frontiers in Tissue Injury and Regeneration Repair)
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18 pages, 5348 KiB  
Article
Injectable Cell-Laden Nanofibrous Matrix for Treating Annulus Fibrosus Defects in Porcine Model: An Organ Culture Study
by Evan Roebke, Diego Jacho, Oliver Eby, Sulaiman Aldoohan, Haitham Elsamaloty and Eda Yildirim-Ayan
Life 2022, 12(11), 1866; https://doi.org/10.3390/life12111866 - 12 Nov 2022
Cited by 5 | Viewed by 1858
Abstract
Lower back pain commonly arises from intervertebral disc (IVD) failure, often caused by deteriorating annulus fibrosus (AF) and/or nucleus pulposus (NP) tissue. High socioeconomic cost, quality of life issues, and unsatisfactory surgical options motivate the rapid development of non-invasive, regenerative repair strategies for [...] Read more.
Lower back pain commonly arises from intervertebral disc (IVD) failure, often caused by deteriorating annulus fibrosus (AF) and/or nucleus pulposus (NP) tissue. High socioeconomic cost, quality of life issues, and unsatisfactory surgical options motivate the rapid development of non-invasive, regenerative repair strategies for lower back pain. This study aims to evaluate the AF regenerative capacity of injectable matrix repair strategy in ex vivo porcine organ culturing using collagen type-I and polycaprolactone nanofibers (PNCOL) with encapsulated fibroblast cells. Upon 14 days organ culturing, the porcine IVDs were assessed using gross optical imaging, magnetic resonance imaging (MRI), histological analysis, and Reverse Transcriptase quantitative PCR (RT-qPCR) to determine the regenerative capabilities of the PNCOL matrix at the AF injury. PNCOL-treated AF defects demonstrated a full recovery with increased gene expressions of AF extracellular matrix markers, including Collagen-I, Aggrecan, Scleraxis, and Tenascin, along with anti-inflammatory markers such as CD206 and IL10. The PNCOL treatment effectively regenerates the AF tissue at the injury site contributing to decreased herniation risk and improved surgical outcomes, thus providing effective non-invasive strategies for treating IVD injuries. Full article
(This article belongs to the Special Issue Frontiers in Tissue Injury and Regeneration Repair)
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8 pages, 549 KiB  
Article
Safety of Electrotherapy Treatment in Patients with Knee Osteoarthritis and Cardiac Diseases
by Laszlo Irsay, Rodica Ana Ungur, Ileana Monica Borda, Irina Tica, Mădălina Gabriela Iliescu, Alina Deniza Ciubean, Theodor Popa, Delia Cinteza, Florina Ligia Popa, Cosmina Ioana Bondor and Viorela Mihaela Ciortea
Life 2022, 12(11), 1690; https://doi.org/10.3390/life12111690 - 24 Oct 2022
Cited by 5 | Viewed by 2503
Abstract
OBJECTIVE: To assess the safety of electrotherapy applied in the knee area in patients with known atrial arrhythmias or ischemic heart disease, as it is not known whether this treatment induces or aggravates arrhythmias during or immediately after therapy. MATERIAL AND METHODS: The [...] Read more.
OBJECTIVE: To assess the safety of electrotherapy applied in the knee area in patients with known atrial arrhythmias or ischemic heart disease, as it is not known whether this treatment induces or aggravates arrhythmias during or immediately after therapy. MATERIAL AND METHODS: The analytical and transversal study involved 46 patients with degenerative knee osteoarthritis (OA), with or without cardiac diseases, from the Clinical Rehabilitation Hospital inpatient center, Cluj-Napoca, Romania. All patients underwent a 10-day physical therapy program for knee OA (electrotherapy, massage and kinesiotherapy). Heart rate and the total number of ventricular and supraventricular extrasystoles were evaluated before and after treatment, by 24 h Holter ECG monitoring. RESULTS: There was no significant increase in heart rate or in the number of ventricular or supraventricular extrasystoles before or after electrotherapy treatment, regardless of the positive or negative history of arrhythmia or ischemic heart disease (all p > 0.05). Mean values during day 1 were: 35.15 (95% CI [9.60–60.75]) for ventricular ones extrasystoles and 91.7 (95% CI [51.69–131.7]) for supraventricular ones, which during day 2 were 38.09 (95% CI [3.68–72.50]), 110.48 (95% CI [48.59–172.36]), respectively. CONCLUSION: One of the most important things to consider when dealing with an OA patient is that they are most likely older than 65 years, which increases the chance of having a cardiac disease. This raises the need for viable interventions regarding the management of this disease in patients that probably have multiple comorbidities, and where pharmacological and surgical management are not possible, limited or have multiple side effects. Electrotherapy used for treating knee OA did not cause a significant increase in heart rate or number of ventricular and supraventricular extrasystoles in this category of patients. Full article
(This article belongs to the Special Issue Frontiers in Tissue Injury and Regeneration Repair)
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17 pages, 4815 KiB  
Article
Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies
by Fatma Rahmouni, Riadh Badraoui, Hmed Ben-Nasr, Fevzi Bardakci, Salem Elkahoui, Arif J. Siddiqui, Mohd Saeed, Mejdi Snoussi, Mongi Saoudi and Tarek Rebai
Life 2022, 12(7), 1092; https://doi.org/10.3390/life12071092 - 21 Jul 2022
Cited by 16 | Viewed by 2293
Abstract
This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium), from Ha'il, and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of [...] Read more.
This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium), from Ha'il, and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of the extract were examined. The in vivo protective study was based on the use of an animal model of CCl4-induced liver cirrhosis. Four groups of rats have been used: Group I: control rats; Group II: received CCl4 in olive oil (0.5 mL/kg); Group III: received the EA T. polium (25 mg/kg) of pretreatment for seven days by gavage then CCl4 in olive oil by gavage for 15 days. Group IV: received the EA of T. polium for seven days (25 mg/kg). EA T. polium was found to possess significant antioxidant capacity. CCl4 caused a hepatotoxicity associated increase in both levels of AST and ALT, which were reduced back to normal values following EA T. polium pretreatment. Hepatotoxicity associated structural modifications of liver tissues and increase in thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and carbonyl proteins (CP), associated decreases in several assessed antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). The in vivo findings on the protective effect of T. polium were supported by its druggability, its pharmacokinetic properties and molecular docking assays. These results confirm the modulatory antioxidant and hepatoprotective potential of T. polium in this experimental liver cirrhosis model. T. polium phytochemicals are good candidates for further pharmaceutical explorations and drug design. Full article
(This article belongs to the Special Issue Frontiers in Tissue Injury and Regeneration Repair)
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