State-of-the-Art in STAT Protein
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".
Deadline for manuscript submissions: closed (18 March 2022) | Viewed by 3622
Special Issue Editor
Special Issue Information
Dear Colleagues,
The signal transducer and activator of transcription (STAT) protein family consists of latent cytoplasmic transcription factors. Since the first discovery of STAT in the 1990s, its structure, activation, function, and regulation have been investigated in a great deal of pathophysiological situations. As the intracellular transcription factors, they mediate a number of areas of physiologic cell processes, including cellular immunity, proliferation, differentiation, and apoptosis. Seven STAT genes in mammalian genomes have been identified so far; namely STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6. Each of them plays a different role in the consideration of diverse extracellular signaling proteins which primarily alter gene transcription in the effector cells. Furthermore, the STAT pathway is connected to the Janus kinases (JAK) family protein, and able to integrate inputs from various signaling pathways. This is why STAT is a potential key mediator in diseases.
This Special Issue aims to gather contributions on review and primary research articles, aiming to update and advance the current knowledge on STAT proteins. The suggested potential topics are not restricted to STAT itself, but also its related protein or involved pathways. Your diverse works will help to clarify the STAT protein, forming numerous insights into many diseases.
Dr. Hyo Jin An
Guest Editor
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Keywords
- STAT
- inflammation
- immunology
- apoptosis
- angiogenesis
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