The Role of Immune Cells in Acute and Chronic Liver Disease
A special issue of Livers (ISSN 2673-4389).
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7659
Special Issue Editors
Interests: immunity; liver diseases; macrophages; inflammation
Special Issue Information
Dear Colleagues,
In recent years, intensive basic, translational, and clinical research has improved our knowledge of the immunopathogenesis of liver diseases. Systemic and hepatic inflammation are key features of acute and chronic liver failure, orchestrated by both innate and adaptive immune cells. It is now widely accepted that liver-resident and/or liver-recruited immune cells play various crucial roles in the development of hepatic inflammation, fibrosis, and progression to cirrhosis. However, it is also clear that key immune-cell populations are vital for liver regeneration and resolution, thereby providing potential opportunities for cell-based therapeutics. Furthermore, technical advances in experimental models and tools, such as single-cell approaches, have enabled us to dissect the key cellular and molecular pathways of immune function, uncovering critical pathophysiological changes involved in different disease states. Yet, success in treating such disorders has been more challenging than initially anticipated, and new effective immune-based therapies for liver diseases remain to be established.
This Special Issue aims to provide insight into recent advances in our immunological understanding of acute and chronic liver failure, as well as the identification of new immunotherapeutic targets and interventions. We welcome the submission of original research and review articles. Liver immunology research areas of interest include, but are not limited to, the following:
- Alcohol- and drug-induced liver injury, including acetaminophen-induced acute liver failure;
- Cirrhosis and acute-on-chronic liver failure;
- Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis;
- Insights from new technological advances such as spatial transcriptomics and RNA sequencing.
We look forward to receiving your contributions.
Dr. Evangelos Triantafyllou
Dr. Patricia Lalor
Guest Editors
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Keywords
- innate immunity
- adaptive immunity
- liver immunology
- liver disease
- inflammation
- acute liver failure
- chronic liver failure
- cirrhosis
- non-alcoholic fatty liver disease
- non-alcoholic and alcoholic steatohepatitis
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