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Marine Drugs
Special Issues
Pharmaceutical and Cosmeceutical Activities of Marine Bioactive Substances and Their...
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Pharmaceutical and Cosmeceutical Activities of Marine Bioactive Substances and Their Bioactive Mechanisms

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 2900

Special Issue Editors

Prof. Dr. Baojun Xu

E-Mail Website
Guest Editor
Food Science and Technology Program, Department of Life Sciences, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai 519087, China
Interests: food science; phytochemicals; nutraceuticals; pharmaceuticals; functional foods; molecular nutrition; cell biology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Bin Du

E-Mail Website
Guest Editor
Hebei Key Laboratory of Natural Products Activity Components and Function, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China
Interests: algae polysaccharide; fucoidan; diabetes; anti-inflammatory activity; mechanism of action; in vitro; in vivo
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

Marine natural products have attracted significant interest as excellent sources of bioactive compounds. Polysaccharides are the main components in marine bioactives. Polysaccharides attract attention due to their numerous health benefits, including pharmaceutical and cosmeceutical activities. However, the molecular mechanisms behind their anti-tumor, anti-inflammatory, anti-tyrosinase, anti-aging and antioxidant activities are not quite clear yet, and further studies are needed to discover the cross-connections in the signaling pathway network. In this Special Issue, we will collect and summarize the existing knowledge on the pharmaceutical and cosmeceutical activities of marine polysaccharides from algae, seacucumber and other marine organisms. Collections may cover in vitro models, animal models and human studies. Finally, the underlying molecular mechanisms of how these marine bioactive compounds regulate their health-promoting effects will be discussed. These studies will offer new chances for further research on biologically active compounds, drugs and pharmaceuticals as well as cosmetics.

Prof. Dr. Baojun Xu
Prof. Dr. Bin Du
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine organisms
  • polysaccharides
  • marine algae
  • sea food
  • sponge
  • cosmeceutical properties
  • skin health promotion
  • pharmacological activities
  • mechanism of action

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Published Papers (1 paper)

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Research

15 pages, 1773 KiB  
Article
Oral Supplementation with Algal Sulphated Polysaccharide in Subjects with Inflammatory Skin Conditions: A Randomised Double-Blind Placebo-Controlled Trial and Baseline Dietary Differences
by Lauren A. Roach, Barbara J. Meyer, J. Helen Fitton and Pia Winberg
Mar. Drugs 2023, 21(7), 379; https://doi.org/10.3390/md21070379 - 27 Jun 2023
Cited by 2 | Viewed by 1855
Abstract
We examined the effect of a dietary seaweed extract—sulfated xylorhamnoglucuronan (SXRG84)—on individuals with inflammatory skin conditions. A subgroup analysis of a larger trial was undertaken, where 44 participants with skin conditions were enrolled in a double-blind placebo-controlled crossover design. Subjects ingested either SXRG84 [...] Read more.
We examined the effect of a dietary seaweed extract—sulfated xylorhamnoglucuronan (SXRG84)—on individuals with inflammatory skin conditions. A subgroup analysis of a larger trial was undertaken, where 44 participants with skin conditions were enrolled in a double-blind placebo-controlled crossover design. Subjects ingested either SXRG84 extract (2 g/day) for six weeks and placebo for six weeks, or vice versa. At baseline, six- and twelve-weeks inflammatory markers and the gut microbiota were assessed, as well as skin assessments using the dermatology quality of life index (DQLI), psoriasis area severity index (PASI) and visual analogue scales (VAS). There were significant differences at weeks six and twelve for pro-inflammatory cytokines IFN-γ (p = 0.041), IL-1β (p = 0.030), TNF-α (p = 0.008) and the anti-inflammatory cytokine IL-10 (p = 0.026), determined by ANCOVA. These cytokines were all significantly higher at six weeks post placebo compared to twelve weeks post placebo followed by SXRG84 treatment. A total of 23% of participants reported skin improvements, as measured by VAS (mean difference 3.1, p = 0.0005) and the DQLI score (mean difference -2.0, p = 0.049), compared to the ‘non-responders’. Thus, the ingestion of SXRG84 for 6 weeks reduced inflammatory cytokines, and a subset of participants saw improvements. Full article
(This article belongs to the Special Issue Pharmaceutical and Cosmeceutical Activities of Marine Bioactive Substances and Their Bioactive Mechanisms)
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