Applications of Lipids from Marine Sources

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2682

Special Issue Editors

CESAM—Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, Aveiro, Portugal
Interests: marine lipidomics; marine invertebrates; macroalgae; mass spectrometry; biotechnological applications; bioactivities of marine lipids
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Guest Editor
CESAM—Centre for Environmental and Marine Studies & Department of Chemistry, University of Aveiro, Aveiro, Portugal
Interests: mass spectrometry lipidomics; marine lipidomics; lipidomics in health and disease; food lipidomics; microbial lipidomics glycomics; biomolecules modification associated with oxidative stress monitored by mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine environments harbor a rich diversity of life systems, including microorganisms, algae, invertebrates and fish, which are an untapped reservoir of bioactive compounds. The diversity of chemical structures found in these organisms has aroused great interest in various fields of research and biotechnology, such as medicine, pharmacology and cosmetic. Bioactive lipids present in marine sources are known for their potential benefits on human health and nutrition, which can be explored for the development of new product with different applications, such as functional foods, feeds and nutraceuticals, as well as in the cosmetic and pharmaceutical sectors.

Recent advances in emerging omics approaches such as lipidomics have contributed to gathering more accurate lipid profiling information for understanding their biological roles and bioprospecting for biotechnological applications.

This Special Issue invites articles covering lipid profiling with a focus in lipidomics as a tool for the discovery and characterization of marine lipids for potential applications in blue biotechnology and bioeconomy.

Dr. Felisa Rey
Dr. Maria do Rosário Domingues
Guest Editors

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Keywords

  • lipidomics
  • marine organisms
  • functional foods
  • blue biotechnology
  • marine lipids

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Published Papers (2 papers)

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Research

32 pages, 4680 KiB  
Article
Comparison of Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome
by Sinemyiz Atalay Ekiner, Agnieszka Gęgotek, Pedro Domingues, Maria Rosário Domingues and Elżbieta Skrzydlewska
Mar. Drugs 2024, 22(11), 509; https://doi.org/10.3390/md22110509 - 10 Nov 2024
Viewed by 1432
Abstract
Lipid extracts from the microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis have great potential to prevent ultraviolet A (UVA)-induced metabolic disorders. Therefore, the aim of this study has been to analyze their cytoprotective effect, focused on maintaining intracellular redox balance and inflammation in UVA-irradiated [...] Read more.
Lipid extracts from the microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis have great potential to prevent ultraviolet A (UVA)-induced metabolic disorders. Therefore, the aim of this study has been to analyze their cytoprotective effect, focused on maintaining intracellular redox balance and inflammation in UVA-irradiated skin fibroblasts, at the proteome level. The above lipid extracts reversed the suppression of the antioxidant response caused by UVA radiation, which was more visible in the case of C. amblystomatis. Modulations of interactions between heme oxygenase-1 and matrix metalloproteinase 1/Parkinson’s disease protein 7/transcript1-α/β, as well as thioredoxin and migration inhibitory factor/Parkinson’s disease protein 7/calnexin/ATPase p97, created key molecular signaling underlying their cytoprotective actions. Moreover, they reduced pro-inflammatory processes in the control group but they also showed the potential to regulate the cellular inflammatory response by changing inflammasome signaling associated with the changes in the caspase-1 interaction area, including heat shock proteins HSP90, HSPA8, and vimentin. Therefore, lipid extracts from N. oceanica and C. amblystomatis protect skin fibroblast metabolism from UVA-induced damage by restoring the redox balance and regulating inflammatory signaling pathways. Thus, those extracts have proven to have great potential to be used in cosmetic or cosmeceutical products to protect the skin against the effects of solar radiation. However, the possibility of their use requires the evaluation of their effects at the skin level in in vivo and clinical studies. Full article
(This article belongs to the Special Issue Applications of Lipids from Marine Sources)
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18 pages, 4668 KiB  
Article
Direct Extraction of Lipids, β-Carotene, and Polyphenolic Compounds from Wet Microalga Dunaliella salina by Liquefied Dimethyl Ether
by Hideki Kanda, Kaito Kusumi, Li Zhu and Tao Wang
Mar. Drugs 2024, 22(10), 438; https://doi.org/10.3390/md22100438 - 26 Sep 2024
Viewed by 933
Abstract
Extraction of lipids and high-value products from highly wet microalgae requires significant energy for the drying pretreatment. In this study, we examined the direct extraction of lipids, β-carotene, and polyphenolic compounds from wet Dunaliella salina using liquefied dimethyl ether (DME), which is effective [...] Read more.
Extraction of lipids and high-value products from highly wet microalgae requires significant energy for the drying pretreatment. In this study, we examined the direct extraction of lipids, β-carotene, and polyphenolic compounds from wet Dunaliella salina using liquefied dimethyl ether (DME), which is effective in lipid extraction for biofuel production. The amount of DME-extracted β-carotene was 7.0 mg/g, which was higher than that obtained from the chloroform–methanol extraction. Moreover, the total phenolic content extracted with DME and its antioxidant capacity were slightly higher than those extracted with chloroform–methanol. DME removed almost all the water and extracted 29.2 wt% of total lipids and 9.7 wt% of fatty acids. More lipids were extracted from wet samples by liquefied DME than by chloroform–methanol extraction. The C/N ratio of lipids extracted with DME was 112.0, higher than that of chloroform–methanol. The high C/N ratio suggests that nitrogen-containing phosphatidylcholines may be less easily extracted by liquefied DME and may be highly selective. However, the ratio of saturated fatty acids was 34.8%, lower than that of chloroform–methanol. Na+ and Mg2+ in the culture medium were not extracted using DME. Thus, using the extract with DME has both advantages and disadvantages compared to using the extract with chloroform–methanol; however, it has satisfactory extraction properties. DME is expected to be an environment-friendly alternative solvent because it does not require drying, which is necessary for conventional extraction solvents. Full article
(This article belongs to the Special Issue Applications of Lipids from Marine Sources)
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