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Marine Drugs
Special Issues
Marine Biorefinery for Bioactive Compounds Production
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Marine Biorefinery for Bioactive Compounds Production

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 15 March 2025 | Viewed by 1483

Special Issue Editors

Dr. Guangling Jiao

E-Mail Website
Guest Editor
1. Investment Associate, Invest Nova Scotia, Halifax, NS, Canada
2. Department of Process Engineering and Applied Science, Faculty of Engineering, Dalhousie University, Halifax, NS B3H 4R2, Canada
Interests: natural health products; bioprocessing; green technologies; bioactive compounds; marine biotech; circular economy
Special Issues, Collections and Topics in MDPI journals
Dr. Yulin Hu

E-Mail Website
Guest Editor
Assistant Professor, Faculty of Sustainable Design Engineering, University of Prince Edward Island, Charlottetown, PE, Canada
Interests: biomass valorization; value-added bioproducts; circular bioeconomy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

We are excited to present a Special Issue of Marine Drugs dedicated to “Marine Biorefinery for Bioactive Compounds Production”. This Special Issue will spotlight the transformative potential of marine resources in the production of bioactive compounds, highlighting both established and emerging techniques in marine biorefinery. Marine organisms are renowned for their diverse and unique biochemical properties, offering a rich source of compounds with significant pharmaceutical, nutraceutical, agricultural, engineering, and industrial applications.

Our aim is to showcase innovative research that addresses the complexities of marine biorefinery processes, including the efficient extraction, characterization, sustainable production and application of these valuable compounds. We seek contributions that provide new insights into the utilization of marine resources, advancements in biotechnological methods, and the development of novel applications that can drive the future of marine-derived bioactive compounds. In addition, recent developments in process scale-up, industrialization, and commercial utilization regarding marine resource-derived bioactive compounds will also be covered in this Special Issue.

Researchers are invited to submit original research articles, comprehensive reviews, and insightful case studies that contribute to the advancement of marine biorefinery technologies and their applications. By participating in this Special Issue, you will join a vibrant scientific community dedicated to harnessing the full potential of marine resources for sustainable and impactful innovations.

Dr. Guangling Jiao
Dr. Yulin Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine biorefinery
  • bioactive compounds
  • marine biotechnology
  • sustainable production
  • marine natural products
  • extraction technologies
  • biochemical characterization
  • pharmaceutical applications
  • nutraceuticals
  • process scale-up and intensification
  • industrial applications
  • life cycle assessment

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Research

10 pages, 1321 KiB  
Article
Influence of Silicate Concentrations on Growth, Carotenoid, and Fatty Acid Profiles of the Marine Diatom Conticribra weissflogii
by David Kwame Amenorfenyo, Feng Li, Xiangyu Rui, Xianghu Huang and Changling Li
Mar. Drugs 2024, 22(11), 504; https://doi.org/10.3390/md22110504 - 6 Nov 2024
Viewed by 620
Abstract
Enhancing microalgal growth and bioactive compound production is becoming a duty for improving photosynthetic microorganisms. In this study, the growth, carotenoid, and fatty acid profiles of Conticribra weissflogii were studied under four different silicate concentrations and silicate-deficient conditions in an f/2 medium with [...] Read more.
Enhancing microalgal growth and bioactive compound production is becoming a duty for improving photosynthetic microorganisms. In this study, the growth, carotenoid, and fatty acid profiles of Conticribra weissflogii were studied under four different silicate concentrations and silicate-deficient conditions in an f/2 medium with continuous aeration, light intensity (30 ± 2 µmol m−2 s−1), salinity (25 ± 2‰), pH (8), and temperature (25 ± 2 °C). At the end of the experiment, we observed that a silicate concentration of 120 mg L−1 produced the maximum biomass dry weight (0.86 g L−1), carotenoid content (1.63 µg mL−1), and fucoxanthin content (1.23 mg g−1) in C. weissflogii. The eicosapentaenoic acid (EPA) (11,354.37 µg g−1), docosahexaenoic acid (DHA) (2516.16 µg g−1), gamma-linolenic acid (C18:3n6) (533.51 µg g−1), and arachidonic acid (C20:4n6) (1261.83 µg g−1) contents were significantly higher at Si 120 mg L−1. The results further showed the maximum fatty acid content in C. weissflogii at Si 120 mg L−1. However, the silicate-deficient conditions (Si 0 mg L−1) resulted in higher levels of saturated fatty acids (38,038.62 µg g−1). This study presents a practical approach for the large-scale optimization of biomass, carotenoid, fucoxanthin, and fatty acid production in C. weissflogii for commercial purposes. Full article
(This article belongs to the Special Issue Marine Biorefinery for Bioactive Compounds Production)
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18 pages, 8761 KiB  
Article
Encapsulation of Microalgae Tisochrysis lutea Extract in Nanostructured Lipid Carriers (NLCs) and Evaluation of Their Sunscreen, Wound Healing, and Skin Hydration Properties
by Natalia Chatzopoulou, Chrysi Chaikali, Eleni Mourkogianni, Constantinos M. Mikelis, Vasilis Andriopoulos, Michael Kornaros, Konstantinos Avgoustakis, Fotini N. Lamari and Sophia Hatziantoniou
Mar. Drugs 2024, 22(11), 487; https://doi.org/10.3390/md22110487 - 30 Oct 2024
Viewed by 671
Abstract
Traditional sunscreens have relied on synthetic compounds to protect against harmful ultraviolet (UV) radiation. However, there is increasing interest in utilizing the natural photoprotective properties of microalgae extracts. This approach does not only aim to enhance the stability and efficacy of sun protection [...] Read more.
Traditional sunscreens have relied on synthetic compounds to protect against harmful ultraviolet (UV) radiation. However, there is increasing interest in utilizing the natural photoprotective properties of microalgae extracts. This approach does not only aim to enhance the stability and efficacy of sun protection formulae but also seeks to reduce the reliance on synthetic sunscreens. This study investigates the encapsulation of Tisochrysis lutea extract (TL) in nanostructured lipid carriers (NLCs) to create a combination (NLC-TL) with enhanced physicochemical stability, antioxidant activity, SPF efficacy, wound healing capacity, and skin hydration. The particle size and ζ-potential were approximately 100 nm and −50 mV, respectively, and both formulations successfully passed the stability tests. The antioxidant activity, measured via DPPH assay, revealed that NLC-TL achieved the highest free radical scavenging activity across all tested concentrations, indicating a synergistic effect. The incorporation of TL in NLCs maintained the sun protection factor (SPF) of a 2% extract solution (1.53 ± 0.13). The wound healing assay indicated that NLC-TLs significantly enhanced wound closure compared to controls and TL alone. Additionally, skin hydration tests on healthy volunteers revealed that NLC-TLs provided superior and sustained hydration effects. These results highlight NLC-TLs’ potential as a multifunctional topical agent for cosmetic and therapeutic applications. Full article
(This article belongs to the Special Issue Marine Biorefinery for Bioactive Compounds Production)
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