Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
4.9
Journals
Marine Drugs
Special Issues
Target Identification of Marine Natural Products
share announcement

Target Identification of Marine Natural Products

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 2207

Special Issue Editor

Prof. Dr. Chuanbin Shen

E-Mail Website
Guest Editor
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
Interests: platelet; thrombosis and hemostasis; adhesion molecules; cardiovascular diseases; targeted therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This issue aims to bring together the latest research and advancements in identifying molecular targets for marine-derived compounds, shedding light on their potential therapeutic applications and mechanisms of action.

Marine organisms have long been recognized as a rich source of bioactive compounds with diverse chemical structures and pharmacological properties. From deep-sea sponges to coastal algae, the oceans harbor a treasure trove of natural products with immense potential for drug discovery and development. However, harnessing the therapeutic potential of marine natural products necessitates a deep understanding of the molecular targets within biological systems. Identifying these targets is crucial for elucidating the underlying mechanisms of action, optimizing drug design, and ultimately translating marine natural products into clinically relevant therapeutics.

This Special Issue welcomes original research articles, reviews, and perspectives covering a wide range of topics related to target identification in marine natural products, including but not limited to innovative approaches and technologies for target identification; mechanistic insights into the biological activities of marine natural products; target identification of marine compounds with therapeutic potential in various disease areas, such as thrombosis, vascular diasorders, cancer, infectious diseases, neurodegenerative disorders, and inflammation; bioinformatics and computational methods for target prediction and validation; case studies highlighting successful target identification and validation processes; and strategies for overcoming challenges in target identification of marine natural products.

For this Special Issue, we encourage researchers from diverse scientific disciplines to contribute their latest findings, reviews, and perspectives to this dynamic and interdisciplinary field to advance our understanding in target identification of marine natural products.

Prof. Dr. Chuanbin Shen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine natural products
  • target identification and validation
  • biomolecular interactions
  • molecular therapy
  • bioactive compounds targeting membrane proteins or nuclear receptors
  • high-throughput screening of bioactive compounds

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

10 pages, 3208 KiB  
Article
Terpenoids from the Soft Coral Sinularia densa Collected in the South China Sea
by Cili Wang, Jiarui Zhang, Kai Li, Junjie Yang, Lei Li, Sen Wang, Hu Hou and Pinglin Li
Mar. Drugs 2024, 22(10), 442; https://doi.org/10.3390/md22100442 - 27 Sep 2024
Viewed by 816
Abstract
The chemical investigation of the South China Sea soft coral Sinularia densa has resulted in the isolation of seven new terpenoids, including two new meroterpenoids, namely sinudenoids F–G (1–2), and five new cembranes, namely sinudenoids H–L (3– [...] Read more.
The chemical investigation of the South China Sea soft coral Sinularia densa has resulted in the isolation of seven new terpenoids, including two new meroterpenoids, namely sinudenoids F–G (1–2), and five new cembranes, namely sinudenoids H–L (3–7). Their structures and absolute configurations were elucidated based on extensive analyses of spectroscopic data, single-crystal X-ray diffraction, comparison with the literature data, and quantum chemical calculations. Among them, sinudenoid F (1) and sinudenoid G (2) are rare meroterpenoids featuring a methyl benzoate core. Sinudenoid H (3) possesses a rare carbon skeleton of 8, 19-bisnorfuranocembrenolide, which is the second reported compound with this skeleton. In a bioassay, sinudenoid H (3) exhibited better anti-inflammatory activity compared to the positive control indomethacin at 20 µM in CuSO4-treated transgenic fluorescent zebrafish. Moreover, sinudenoid J (5) and sinudenoid L (7) exhibited moderate anti-thrombotic activity in arachidonic acid (AA)-induced thrombotic zebrafish at 20 µM. Full article
(This article belongs to the Special Issue Target Identification of Marine Natural Products)
►▼ Show Figures

Graphical abstract

14 pages, 2711 KiB  
Article
Stichoposide C and Rhizochalin as Potential Aquaglyceroporin Modulators
by Ji Woo Im, Ju Hyun Lim, Valentin A. Stonik, Jong-Young Kwak, Songwan Jin, Minkook Son and Hae-Rahn Bae
Mar. Drugs 2024, 22(8), 335; https://doi.org/10.3390/md22080335 - 25 Jul 2024
Viewed by 1052
Abstract
Aquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQP-based therapeutics may have the broad potential for clinical utility, [...] Read more.
Aquaporins (AQPs) are a family of integral membrane proteins that selectively transport water and glycerol across the cell membrane. Because AQPs are involved in a wide range of physiological functions and pathophysiological conditions, AQP-based therapeutics may have the broad potential for clinical utility, including for disorders of water and energy balance. However, AQP modulators have not yet been developed as suitable candidates for clinical applications. In this study, to identify potential modulators of AQPs, we screened 31 natural products by measuring the water and glycerol permeability of mouse erythrocyte membranes using a stopped-flow light scattering method. None of the tested natural compounds substantially affected the osmotic water permeability. However, several compounds considerably affected the glycerol permeability. Stichoposide C increased the glycerol permeability of mouse erythrocyte membranes, whereas rhizochalin decreased it at nanomolar concentrations. Immunohistochemistry revealed that AQP7 was the main aquaglyceroporin in mouse erythrocyte membranes. We further verified the effects of stichoposide C and rhizochalin on aquaglyceroporins using human AQP3-expressing keratinocyte cells. Stichoposide C, but not stichoposide D, increased AQP3-mediated transepithelial glycerol transport, whereas the peracetyl aglycon of rhizochalin was the most potent inhibitor of glycerol transport among the tested rhizochalin derivatives. Collectively, stichoposide C and the peracetyl aglycon of rhizochalin might function as modulators of AQP3 and AQP7, and suggests the possibility of these natural products as potential drug candidates for aquaglyceroporin modulators. Full article
(This article belongs to the Special Issue Target Identification of Marine Natural Products)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop