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Journals
Marine Drugs
Special Issues
Marine Algal Compounds with Antimicrobial Activities
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Marine Algal Compounds with Antimicrobial Activities

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3769

Special Issue Editor

Dr. Adele Cutignano

E-Mail Website
Guest Editor
Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy
Interests: natural products chemistry; bioactive metabolites; structural characterization; NMR; mass spectrometry; lipidomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

Photosynthetic organisms represent an important source of bioactive compounds that can be exploited in pharmaceutical and nutraceutical sectors. In the marine environment, macroalgae and microalgae are among the main reported sources of marine natural products for discovering novel drugs. Widely distributed, they can survive in extreme conditions and produce highly diverse secondary metabolites, including terpenoids, peptides, and fatty acid derivatives. The focus of this Special Issue is on novel metabolites from algae that show promising bioactivities, particularly against resistant bacteria and viruses. The recent COVID-19 pandemic highlighted the need for antiviral drugs. On the other hand, the difficulties encountered in the treatment of infections caused by microorganisms no longer responding to antimicrobial medicines necessitate the discovery and selection of more effective antibiotics.

Original research studies and literature reviews on algal-derived novel chemical structures with promising activities to fight antimicrobial resistance (AMR) are welcome.

Dr. Adele Cutignano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine microalgae
  • marine macroalgae
  • secondary metabolites
  • structural characterization
  • AMR
  • antibiotic
  • antiviral

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Published Papers (3 papers)

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Research

12 pages, 1439 KiB  
Article
Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan
by Akira Iwata, Mayuko Yamamoto-Fujimura, Suzuka Fujiwara, Saya Tajima, Takahide Shigeyama, Moriya Tsukimoto, Tatsuya Ibuki and Akito Kataoka-Kato
Mar. Drugs 2024, 22(11), 486; https://doi.org/10.3390/md22110486 - 29 Oct 2024
Viewed by 578
Abstract
The COVID-19 pandemic has significantly impacted our daily lives. Routine infection-control measures present an effective preventive strategy for a new infectious disease outbreak. Fucoidan, a fucose-rich sulfated polysaccharide found in brown algae, exhibits antiviral activity. Moreover, fucoidan exerts an antimicrobial effect; however, it [...] Read more.
The COVID-19 pandemic has significantly impacted our daily lives. Routine infection-control measures present an effective preventive strategy for a new infectious disease outbreak. Fucoidan, a fucose-rich sulfated polysaccharide found in brown algae, exhibits antiviral activity. Moreover, fucoidan exerts an antimicrobial effect; however, it requires considerably higher concentrations than those needed for its antiviral effect. In this study, we aimed to enhance the antimicrobial activity of fucoidan and prepared a fucoidan silver salt (Ag-Fuc) by incorporating silver ions into the sulfate groups of Yakult Fucoidan derived from Cladosiphon okamuranus Tokida. The fucoidan exhibited a weak inhibitory effect on Escherichia coli growth at significantly higher concentrations, whereas Ag-Fuc inhibited the growth of E. coli and Staphylococcus epidermidis at concentrations comparable to those required for its antiviral effects. Moreover, Ag-Fuc inhibited the growth of Cladosporium cladosporioides. Infections of human cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus were more effectively inhibited by lower concentrations of Ag-Fuc compared with fucoidan. Overall, silver ions added to the sulfate groups induced strong antimicrobial activity and enhanced the antiviral effect of fucoidan. We suggest a wide application of Ag-Fuc as a routine preventive material to avoid new infectious disease pandemics. Full article
(This article belongs to the Special Issue Marine Algal Compounds with Antimicrobial Activities)
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14 pages, 1556 KiB  
Article
Antiviral Effect of Microalgae Phaeodactylum tricornutum Protein Hydrolysates against Dengue Virus Serotype 2
by Bianca Vianey Rivera-Serrano, Sandy Lucero Cabanillas-Salcido, Carlos Daniel Cordero-Rivera, Ricardo Jiménez-Camacho, Claudia Desiree Norzagaray-Valenzuela, Loranda Calderón-Zamora, Luis Adrián De Jesús-González, José Manuel Reyes-Ruiz, Carlos Noe Farfan-Morales, Alejandra Romero-Utrilla, Víctor Manuel Ruíz-Ruelas, Josué Camberos-Barraza, Alejandro Camacho-Zamora, Alberto Kousuke De la Herrán-Arita, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Ángel Radamés Rábago-Monzón, Janitzio Xiomara Korina Perales-Sánchez, Marco Antonio Valdez-Flores, Rosa María Del Ángel and Juan Fidel Osuna-Ramosadd Show full author list remove Hide full author list
Mar. Drugs 2024, 22(8), 369; https://doi.org/10.3390/md22080369 - 14 Aug 2024
Viewed by 1842
Abstract
Dengue, caused by the dengue virus (DENV), is a global health threat transmitted by Aedes mosquitoes, resulting in 400 million cases annually. The disease ranges from mild to severe, with potential progression to hemorrhagic dengue. Current research is focused on natural antivirals due [...] Read more.
Dengue, caused by the dengue virus (DENV), is a global health threat transmitted by Aedes mosquitoes, resulting in 400 million cases annually. The disease ranges from mild to severe, with potential progression to hemorrhagic dengue. Current research is focused on natural antivirals due to challenges in vector control. This study evaluates the antiviral potential of peptides derived from the microalgae Phaeodactylum tricornutum, known for its bioactive compounds. Microalgae were cultivated under controlled conditions, followed by protein extraction and hydrolysis to produce four peptide fractions. These fractions were assessed for cytotoxicity via the MTT assay and antiviral activity against DENV serotype 2 using flow cytometry and plaque formation assays. The 10–30 kDa peptide fraction, at 150 and 300 μg/mL concentrations, demonstrated no cytotoxicity and significantly reduced the percentage of infected cells and viral titers. These findings suggest that peptides derived from Phaeodactylum tricornutum exhibit promising antiviral activity against dengue virus serotype 2, potentially contributing to developing new therapeutic approaches for dengue. Full article
(This article belongs to the Special Issue Marine Algal Compounds with Antimicrobial Activities)
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13 pages, 1960 KiB  
Article
In Vitro Anti-HIV-1 Activity of Fucoidans from Brown Algae
by Marina N. Nosik, Natalya V. Krylova, Roza V. Usoltseva, Valerii V. Surits, Dmitry E. Kireev, Mikhail Yu. Shchelkanov, Oxana A. Svitich and Svetlana P. Ermakova
Mar. Drugs 2024, 22(8), 355; https://doi.org/10.3390/md22080355 - 31 Jul 2024
Viewed by 1039
Abstract
Due to the developing resistance and intolerance to antiretroviral drugs, there is an urgent demand for alternative agents that can suppress the viral load in people living with human immunodeficiency virus (HIV). Recently, there has been increased interest in agents of marine origin [...] Read more.
Due to the developing resistance and intolerance to antiretroviral drugs, there is an urgent demand for alternative agents that can suppress the viral load in people living with human immunodeficiency virus (HIV). Recently, there has been increased interest in agents of marine origin such as, in particular, fucoidans to suppress HIV replication. In the present study, the anti-HIV-1 activity of fucoidans from the brown algae Alaria marginata, Alaria ochotensis, Laminaria longipes, Saccharina cichorioides, Saccharina gurianovae, and Tauya basicrassa was studied in vitro. The studied compounds were found to be able to inhibit HIV-1 replication at different stages of the virus life cycle. Herewith, all fucoidans exhibited significant antiviral activity by affecting the early stages of the virus–cell interaction. The fucoidan from Saccharina cichorioides showed the highest virus-inhibitory activity by blocking the virus’ attachment to and entry into the host’s cell, with a selectivity index (SI) > 160. Full article
(This article belongs to the Special Issue Marine Algal Compounds with Antimicrobial Activities)
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