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Marine Drugs
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Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides—2nd...
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Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides—2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 5099

Special Issue Editor

Dr. Lijun You

E-Mail Website
Guest Editor
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: polysaccharides; hypoglycemic; anticancer; antioxidant; anti-UV radiation activities; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

In consideration of the success of the Special Issue entitled "Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides” ( https://www.mdpi.com/journal/marinedrugs/special_issues/0N46V2O762 ) and the relevant interest in the topic, I am pleased to announce the second version of this Special Issue.

Polysaccharides and peptides play a vital role in the areas of human wellness and food. They have been reported to present various physiological and biological activities based on their specific chemical structures. However, their structure–function relationships are yet to be established. Today, special attention has been paid to investigating their structure–function relationships and the mechanisms of their biological activities, which facilitate their use as food ingredients or bioactive compounds in the food and pharmaceutical fields.

The purpose of this Special Issue is to feature the latest, high-quality, advanced research and knowledge contributed by various research groups all around the world working on polysaccharides and peptides from marine sources, which will shape future research directions.

We would like to invite scientists to participate in this Special Issue by submitting an updated and new base of knowledge on the isolation, identification and applications of marine source polysaccharides and peptides.

Potential topics include, but are not limited to, the following:

  • Isolation and structural identification of marine-source polysaccharides or peptides.
  • Effects of processing methods on the functions of marine-source polysaccharides or peptides.
  • Functions of marine-source polysaccharides or peptides and in vitro or in vivo evaluation.
  • Industrial and potential applications of marine-source polysaccharides or peptides.
  • Product research and development of marine-source polysaccharides or peptides.

Dr. Lijun You
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • isolation
  • structure
  • polysaccharide
  • peptide
  • identification
  • biological activity

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Published Papers (3 papers)

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Research

17 pages, 3873 KiB  
Article
Calcium Transport Activity of UV/H2O2-Degraded Fucoidans and Their Structural Characterization
by Biyang Zhu, Jiacheng Wang, Lijun You, Lianzhu Lin, Kuncheng Lin and Kseniya Hileuskaya
Mar. Drugs 2024, 22(11), 499; https://doi.org/10.3390/md22110499 - 4 Nov 2024
Viewed by 581
Abstract
Calcium-chelated polysaccharides have been increasingly considered as promising calcium supplements. In this study, degraded fucoidans (DFs) with different molecular weights (Mws) were prepared after UV/H2O2 treatment; their calcium-chelating capacities and intestinal absorption properties were also investigated. The results showed that [...] Read more.
Calcium-chelated polysaccharides have been increasingly considered as promising calcium supplements. In this study, degraded fucoidans (DFs) with different molecular weights (Mws) were prepared after UV/H2O2 treatment; their calcium-chelating capacities and intestinal absorption properties were also investigated. The results showed that the calcium-chelating capacities of DFs were improved with a decrease in Mw. This was mainly ascribed to the increased carboxyl content, which was caused by free-radical-mediated degradation. Meanwhile, the conformation of DF changed from a rod-like chain to a shorter and softer chain. The thermodynamic analysis demonstrated that DF binding to calcium was spontaneously driven by electrostatic interactions. Additionally, DF-Ca chelates with lower Mw showed favorable transport properties across a Caco-2 cell monolayer and could effectively accelerate the calcium influx through intestinal enterocytes. Furthermore, these chelates also exhibited a protective effect on the epithelial barrier by alleviating damage to tight junction proteins. These findings provide an effective free-radical-related approach for the development of polysaccharide-based calcium supplements with improved intestinal calcium transport ability. Full article
(This article belongs to the Special Issue Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides—2nd Edition)
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20 pages, 849 KiB  
Article
pH-Dependent Extraction of Antioxidant Peptides from Red Seaweed Palmaria palmata: A Sequential Approach
by Sakhi Ghelichi, Ann-Dorit Moltke Sørensen, Grazielle Náthia-Neves and Charlotte Jacobsen
Mar. Drugs 2024, 22(9), 413; https://doi.org/10.3390/md22090413 - 10 Sep 2024
Viewed by 947
Abstract
This study employed a diverse approach to extract antioxidant peptides from red seaweed Palmaria palmata, recognized for its comparatively high protein content. Initially, an aqueous extraction of the entire seaweed was performed, followed by enzymatic hydrolysis of the solid residues prepared from [...] Read more.
This study employed a diverse approach to extract antioxidant peptides from red seaweed Palmaria palmata, recognized for its comparatively high protein content. Initially, an aqueous extraction of the entire seaweed was performed, followed by enzymatic hydrolysis of the solid residues prepared from the first step. The effects of three different pH levels (3, 6, and 9) during the aqueous extraction were also examined. Results indicated that the solid fraction from the sequential extraction process contained significantly higher levels of proteins and amino acids than other fractions (p < 0.05). Furthermore, the solid fractions (IC50 ranging from 2.29 to 8.15 mg.mL−1) demonstrated significantly greater free radical scavengers than the liquid fractions (IC50 ranging from 9.03 to 10.41 mg.mL−1 or not obtained at the highest concentration tested) at both stages of extraction (p < 0.05). Among the solid fractions, those produced fractions under alkaline conditions were less effective in radical scavenging than the produced fractions under acidic or neutral conditions. The fractions with most effective metal ion chelating activity were the solid fractions from the enzymatic stage, particularly at pH 3 (IC50 = 0.63 ± 0.04 mg.mL−1) and pH 6 (IC50 = 0.89 ± 0.07 mg.mL−1), which were significantly more effective than those from the initial extraction stage (p < 0.05). Despite no significant difference in the total phenolic content between these solid fractions and their corresponding liquid fractions (3.79 ± 0.05 vs. 3.48 ± 0.02 mg.mL−1 at pH 3 and 2.43 ± 0.22 vs. 2.51 ± 0.00 mg.mL−1 at pH 6) (p > 0.05), the observed antioxidant properties may be attributed to bioactive amino acids such as histidine, glutamic acid, aspartic acid, tyrosine, and methionine, either as free amino acids or within proteins and peptides. Full article
(This article belongs to the Special Issue Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides—2nd Edition)
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27 pages, 8736 KiB  
Article
Ameliorative Effect of Chitosan/Spirulina platensis Ethanolic Extract Nanoformulation against Cyclophosphamide-Induced Ovarian Toxicity: Role of PPAR-γ/Nrf-2/HO-1 and NF-kB/TNF-α Signaling Pathways
by May Almukainzi, Thanaa A. El-Masry, Hanaa A. Ibrahim, Hebatallah M. Saad, Enas I. El Zahaby, Asmaa Saleh and Maysa M. F. El-Nagar
Mar. Drugs 2024, 22(9), 395; https://doi.org/10.3390/md22090395 - 30 Aug 2024
Viewed by 3354
Abstract
Cyclophosphamide (CP) is an anticancer drug that causes infertility disorders. This study was designed to evaluate a nanoformulation of chitosan with an ethanolic extract from Spirulina platensis in terms of its protection against cyclophosphamide-induced ovarian toxicity. Nine groups of female Wistar rats were [...] Read more.
Cyclophosphamide (CP) is an anticancer drug that causes infertility disorders. This study was designed to evaluate a nanoformulation of chitosan with an ethanolic extract from Spirulina platensis in terms of its protection against cyclophosphamide-induced ovarian toxicity. Nine groups of female Wistar rats were randomly assigned as follows: 1: control vehicle, 2: chitosan polymer, 3: telmisartan, 4: Spirulina platensis extract, 5: nanoformulation of the Spirulina platensis, and 6: single injection of CP; groups 7, 8, and 9 received the same treatments as those used in groups 3, 4, and 5, respectively, with a single dose of CP (200 mg/kg, I.P). The results displayed that the CP treatment decreased estradiol, progesterone, anti-mullerian hormone, and GSH content, and it downregulated PPAR-γ, Nrf-2, and HO-1 gene expression. In addition, the CP treatment caused an increase in the FSH, LH, and MDA levels. In the same manner, the protein expression of caspase-3, NF-kB, and TNF-α was upregulated in response to the CP treatment, while PPAR-γ was downregulated in comparison with the control. The rats treated with SPNPs exhibited a substantial reduction in the detrimental effects of oxidative stress and inflammation of the ovarian tissue. This study’s conclusions showed that SPNPs counteracted the effects of CP, preventing the death of ovarian follicles and restoring the gonadotropin hormone balance and normal ovarian histological appearance. Full article
(This article belongs to the Special Issue Isolation, Identification and Applications of Marine Source Polysaccharides and Peptides—2nd Edition)
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