Marine Polyether Compounds
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 2673
Special Issue Editor
Interests: organic synthesis; fatty acids; marine steroids; antitumor; lipids; alkaloids; terpenoids
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Marine polyester compounds are a class of organic compounds that are derivatives of squalene, as well as polyunsaturated fatty acids, and possess a broad spectrum of antitumor activity withantimicrobial and antifungal effects.
For example, okadaic acid, also known as a marine polycyclic ether toxin, called gambierol, and its derivatives was discovered more than 50 years ago,among many others that produce marine dinoflagellates.
For more than fifty years, in many countries of the world, scholars have studied polyether compounds that were isolated from Actinobacteria belonging to the largest genus, Streptomyces.
These bacteria produce well-known antibiotics, such as tetronomycins, noboritomycins, monensins.
In addition to these antibiotics, ionophoric polyethers of the genus Streptomyces synthesizes promomycin, as well as the related ionophoric polyethers, such as A80438, mutalomycin and lomonomycin.
In addition, myxobacterium Sorangium is known to produce antibiotics called sorangicins.
These polyester compounds are produced by unicellular algae, red algae, sea sponges, and coelenterates or are accumulated by some marine organisms, such as bivalve molluscs. Thus, they are also known as phycotoxins and are largely produced by phytoplankton, in particular dinoflagellates and diatoms.
However, the activity of many polyester compounds and their derivatives has not yet been studied, but there is a strong belief that other types of biological activity may be discovered in the near future.
Prof. Dr. Valery Dembitsky
Guest Editor
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Keywords
- polyester compounds
- squalene
- polyunsaturated fatty acids
- antitumor
- antimicrobial
- antifungal okadaic acid
- phycotoxin
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