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New Insights into Hybrid Biomaterials
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New Insights into Hybrid Biomaterials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 8853

Special Issue Editors

Prof. Dr. Vassilios Roussis

E-Mail Website
Guest Editor
Department of Pharmacy, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: biomedical applications; electrospinning; nanofibers; hybrid materials; marine biopolymers
Special Issues, Collections and Topics in MDPI journals
Dr. Efstathia Ioannou

E-Mail Website
Guest Editor
Department of Pharmacy, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: isolation; structure elucidation; marine natural products; marine biopolymers; marine-derived microorganisms
Special Issues, Collections and Topics in MDPI journals
Dr. Leto-Aikaterini Tziveleka

E-Mail Website
Guest Editor
Department of Pharmacy, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: functional biomaterials; biocompatible polymers; controlled delivery of bioactive molecules; drug targeting; tissue engineering; nanoparticles; scaffolds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of hybrid biomaterials is attracting constantly increasing interest for applications in the biomedical sector, such as tissue engineering, regenerative medicine, drug delivery or gene therapy, and design of diagnostic systems. Frequently, intrinsic shortcomings of a single chemical render the development of hybrid biomaterials as the most appropriate way to achieve the desired and necessary properties for selected bioapplications, allowing for interaction with key components of living systems. Hybrid biomaterials with highly tailored physicochemical properties and bioactivity can be engineered, utilizing different biodegradable natural-based and/or synthetic polymers and inorganic molecules and can be shaped in various forms depending on the desired application, including 3D scaffolds, hydrogels, microspheres, nanoparticles, and their composites. Due to their hybrid structure, they demonstrate excellent tunable mechanical and physicochemical properties, including viscoelasticity and strength, as well as improved biological activity, including cellular biocompatibility and tissue-inductive ability.

The successful design and the detailed characterization of such biomaterials, which entangles the contribution of material, physical, chemical, and biological sciences, represents a major interdisciplinary challenge. The Special Issue will include contributions that demonstrate how an understanding of the basic chemical and physical phenomena may direct materials design and stimulate ideas for new or improved processing techniques, in order to obtain biomaterials with desired structural features and properties.

Prof. Vassilios Roussis
Assis. Prof. Efstathia Ioannou
Dr. Leto-Aikaterini Tziveleka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hybrid biomaterials
  • biomedical applications
  • design and characterization

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Published Papers (2 papers)

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Research

17 pages, 4498 KiB  
Article
Red-Emitting Hybrid Based on Eu3+-dbm Complex Anchored on Silica Nanoparticles Surface by Carboxylic Acid for Biomarker Application
by João A. O. Santos, Alessandra M. G. Mutti, Airton G. Bispo-Jr, Ana M. Pires and Sergio A. M. Lima
Materials 2020, 13(23), 5494; https://doi.org/10.3390/ma13235494 - 2 Dec 2020
Cited by 9 | Viewed by 3900
Abstract
Luminescent organic-inorganic hybrids containing lanthanides (Ln3+) have been prominent for applications such as luminescent bio-probes in biological assays. In this sense, a luminescent hybrid based on dense silica (SiO2) nanospheres decorated with Eu3+ β–diketonate complexes using dibenzoylmethane (Hdbm) [...] Read more.
Luminescent organic-inorganic hybrids containing lanthanides (Ln3+) have been prominent for applications such as luminescent bio-probes in biological assays. In this sense, a luminescent hybrid based on dense silica (SiO2) nanospheres decorated with Eu3+ β–diketonate complexes using dibenzoylmethane (Hdbm) as a luminescent antenna was developed by using a hierarchical organization in four steps: (i) anchoring of 3-aminopropyltriethoxysilane (APTES) organosilane on the SiO2 surface, (ii) formation of a carboxylic acid ligand, (iii) coordination of Eu3+ to the carboxylate groups and (iv) coordination of dbm− to Eu3+. The hybrid structure was elucidated through the correlation of thermogravimetry, silicon nuclear magnetic resonance and photoluminescence. Results indicate that the carboxylic acid-Eu3+-dbm hybrid was formed on the surface of the particles with no detectable changes on their size or shape after all the four steps (average size of 32 ± 7 nm). A surface charge of −27.8 mV was achieved for the hybrid, assuring a stable suspension in aqueous media. The Eu3+ complex provides intense red luminescence, characteristic of Eu3+5D0→7FJ electronic transitions, with an intrinsic emission quantum yield of 38%, even in an aqueous suspension. Therefore, the correlation of luminescence, structure, particle morphology and fluorescence microscopy images make the hybrid promising for application in bioimaging. Full article
(This article belongs to the Special Issue New Insights into Hybrid Biomaterials)
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20 pages, 4993 KiB  
Article
Hybrid Sponge-Like Scaffolds Based on Ulvan and Gelatin: Design, Characterization and Evaluation of Their Potential Use in Bone Tissue Engineering
by Leto-Aikaterini Tziveleka, Andreas Sapalidis, Stefanos Kikionis, Eleni Aggelidou, Efterpi Demiri, Aristeidis Kritis, Efstathia Ioannou and Vassilios Roussis
Materials 2020, 13(7), 1763; https://doi.org/10.3390/ma13071763 - 9 Apr 2020
Cited by 35 | Viewed by 3668
Abstract
Ulvan, a bioactive natural sulfated polysaccharide, and gelatin, a collagen-derived biopolymer, have attracted interest for the preparation of biomaterials for different biomedical applications, due to their demonstrated compatibility for cell attachment and proliferation. Both ulvan and gelatin have exhibited osteoinductive potential, either alone [...] Read more.
Ulvan, a bioactive natural sulfated polysaccharide, and gelatin, a collagen-derived biopolymer, have attracted interest for the preparation of biomaterials for different biomedical applications, due to their demonstrated compatibility for cell attachment and proliferation. Both ulvan and gelatin have exhibited osteoinductive potential, either alone or in combination with other materials. In the current work, a series of novel hybrid scaffolds based on crosslinked ulvan and gelatin was designed, prepared and characterized. Their mechanical performance, thermal stability, porosity, water-uptake and in vitro degradation ability were assessed, while their morphology was analyzed through scanning electron microscopy. The prepared hybrid ulvan/gelatin scaffolds were characterized by a highly porous and interconnected structure. Human adipose-derived mesenchymal stem cells (hADMSCs) were seeded in selected ulvan/gelatin hybrid scaffolds and their adhesion, survival, proliferation, and osteogenic differentiation efficiency was evaluated. Overall, it was found that the prepared hybrid sponge-like scaffolds could efficiently support mesenchymal stem cells’ adhesion and proliferation, suggesting that such scaffolds could have potential uses in bone tissue engineering. Full article
(This article belongs to the Special Issue New Insights into Hybrid Biomaterials)
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