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Advanced Antimicrobial Materials
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Advanced Antimicrobial Materials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 22720

Special Issue Editors

Dr. Thibaud Coradin

E-Mail Website
Guest Editor
Laboratoire Chimie de la Matière Condensée de Paris, Sorbonne Université, CNRS, UMR 7574, 4 Place Jussieu, 75005 Paris, France
Interests: biomaterials; bionanocomposites; bio-hybrids; hydrogels: silica; collagen; biominerals
Special Issues, Collections and Topics in MDPI journals
Dr. Davy-Louis Versace

E-Mail Website
Guest Editor
CNRS Centre National de la Recherche Scientifique, Paris, France
Interests: photo-initiators; bio-sourced molecules; photoinduced bio-based materials; antibacterial coatings; micro-structures; dental restorations; nanotechnology; polymer synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nosocomial infections (NIs) have been a worldwide healthcare issue for decades. Due to the incredible increase of bacterial resistance towards medicines, infections continue to proliferate, and thousands of deaths in hospitals have been counted. Some studies have provided an estimation of the number of NIs annually observed in the US, where around two million patients suffer from NIs during hospital stays and nearly 90,000 are estimated to die. In the UK, 300,000 people acquire infections in hospitals each year, resulting in nearly 5000 deaths. In addition to these alarming statistics, more than £1 billion per year in UK and at least $10 billion annually in the US are spent to struggle against healthcare-associated infections (HAIs) according to the Office for National Statistics, and these costs come directly out of the hospital’s wallet. The spread of micro-organisms should be urgently limited because the projected mortality rate due to HAIs is estimated to reach more than 10 million per year in 2050, which is higher than the projected rate for cancer.

In order to prevent this risk, many devices used in hospitals (surgical/food trays, stainless steel substrates, catheters, operation tools) have been covered with antibacterial coatings which could either kill micro-organisms (biocidal coatings) or prevent their adhesion/growth (passive coatings). In this context, a wide diversity of materials, including nature-inspired materials that mimic fauna-based surfaces, cationic-polymer-based materials, photoactive materials and nanocomposites containing metal and metal oxide nanoparticles (NPs), have been described in literature. While impressive antibacterial properties were often reported, many challenges in terms of durability, sustainability and efficiency in “real” (hospital) conditions remain. Moreover, beyond coatings, 3D materials exhibiting antimicrobial properties could find tremendous medical applications, especially in tissue engineering

This Special Issue is dedicated to original research and review papers of the highest quality that consider the synthesis and design of new antimicrobial materials (e.g., coatings, films, hydrogels, 3D systems) which significantly prevent the growth of or eradicate bacteria. While centered on materials science, contributions to this Special Issue are expected to have significant microbiological relevance.

Dr. Thibaud Coradin
Dr. Davy-Louis Versace
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifouling materials
  • biocidal materials
  • photoactive antimicrobial materials
  • micro/nano-structured antimicrobial materials
  • polymer-based antimicrobial materials
  • bio-based antimicrobial food packaging films
  • nature-inspired materials
  • antimicrobial nanomaterials and nanocomposites
  • biomedical applications

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Published Papers (4 papers)

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Research

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11 pages, 3128 KiB  
Article
Antibacterial Polymers Based on Poly(2-hydroxyethyl methacrylate) and Thiazolium Groups with Hydrolytically Labile Linkages Leading to Inactive and Low Cytotoxic Compounds
by Rocío Cuervo-Rodríguez, Fátima López-Fabal, Alexandra Muñoz-Bonilla and Marta Fernández-García
Materials 2021, 14(23), 7477; https://doi.org/10.3390/ma14237477 - 6 Dec 2021
Cited by 4 | Viewed by 2478
Abstract
Herein, we develop a well-defined antibacterial polymer based on poly(2-hydroxyethyl methacrylate) (PHEMA) and a derivative of vitamin B1, easily degradable into inactive and biocompatible compounds. Hence, thiazole moiety was attached to HEMA monomer through a carbonate pH-sensitive linkage and the resulting monomer was [...] Read more.
Herein, we develop a well-defined antibacterial polymer based on poly(2-hydroxyethyl methacrylate) (PHEMA) and a derivative of vitamin B1, easily degradable into inactive and biocompatible compounds. Hence, thiazole moiety was attached to HEMA monomer through a carbonate pH-sensitive linkage and the resulting monomer was polymerized via reversible addition-fragmentation chain transfer (RAFT) polymerization. N-alkylation reaction of the thiazole groups leads to cationic polymer with thiazolium groups. This polymer exhibits excellent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with an MIC value of 78 µg mL−1, whereas its degradation product, thiazolium small molecule, was found to be inactive. Hemotoxicity studies confirm the negligible cytotoxicity of the degradation product in comparison with the original antibacterial polymer. The degradation of the polymer at physiological pH was found to be progressive and slow, thus the cationic polymer is expected to maintain its antibacterial characteristics at physiological conditions for a relative long period of time before its degradation. This degradation minimizes antimicrobial pollution in the environment and side effects in the body after eradicating bacterial infection. Full article
(This article belongs to the Special Issue Advanced Antimicrobial Materials)
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12 pages, 2904 KiB  
Article
Fabrication of Gelatin-ZnO Nanofibers for Antibacterial Applications
by Nataliya Babayevska, Łucja Przysiecka, Grzegorz Nowaczyk, Marcin Jarek, Martin Järvekülg, Triin Kangur, Ewa Janiszewska, Stefan Jurga and Igor Iatsunskyi
Materials 2021, 14(1), 103; https://doi.org/10.3390/ma14010103 - 29 Dec 2020
Cited by 20 | Viewed by 3465
Abstract
In this study, GNF@ZnO composites (gelatin nanofibers (GNF) with zinc oxide (ZnO) nanoparticles (NPs)) as a novel antibacterial agent were obtained using a wet chemistry approach. The physicochemical characterization of ZnO nanoparticles (NPs) and GNF@ZnO composites, as well as the evaluation of their [...] Read more.
In this study, GNF@ZnO composites (gelatin nanofibers (GNF) with zinc oxide (ZnO) nanoparticles (NPs)) as a novel antibacterial agent were obtained using a wet chemistry approach. The physicochemical characterization of ZnO nanoparticles (NPs) and GNF@ZnO composites, as well as the evaluation of their antibacterial activity toward Gram-positive (Staphyloccocus aureus and Bacillus pumilus) and Gram-negative (Escherichia coli and Pseudomonas fluorescens) bacteria were performed. ZnO NPs were synthesized using a facile sol-gel approach. Gelatin nanofibers (GNF) were obtained by an electrospinning technique. GNF@ZnO composites were obtained by adding previously produced GNF into a Zn2+ methanol solution during ZnO NPs synthesis. Crystal structure, phase, and elemental compositions, morphology, as well as photoluminescent properties of pristine ZnO NPs, pristine GNF, and GNF@ZnO composites were characterized using powder X-ray diffraction (XRD), FTIR analysis, transmission and scanning electron microscopies (TEM/SEM), and photoluminescence spectroscopy. SEM, EDX, as well as FTIR analyses, confirmed the adsorption of ZnO NPs on the GNF surface. The pristine ZnO NPs were highly crystalline and monodispersed with a size of approximately 7 nm and had a high surface area (83 m2/g). The thickness of the pristine gelatin nanofiber was around 1 µm. The antibacterial properties of GNF@ZnO composites were investigated by a disk diffusion assay on agar plates. Results show that both pristine ZnO NPs and their GNF-based composites have the strongest antibacterial properties against Pseudomonas fluorescence and Staphylococcus aureus, with the zone of inhibition above 10 mm. Right behind them is Escherichia coli with slightly less inhibition of bacterial growth. These properties of GNF@ZnO composites suggest their suitability for a range of antimicrobial uses, such as in the food industry or in biomedical applications. Full article
(This article belongs to the Special Issue Advanced Antimicrobial Materials)
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Review

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33 pages, 9660 KiB  
Review
Light and Hydrogels: A New Generation of Antimicrobial Materials
by Lucie Pierau and Davy-Louis Versace
Materials 2021, 14(4), 787; https://doi.org/10.3390/ma14040787 - 7 Feb 2021
Cited by 21 | Viewed by 3431
Abstract
Nosocomial diseases are becoming a scourge in hospitals worldwide, and new multidrug-resistant microorganisms are appearing at the forefront, significantly increasing the number of deaths. Innovative solutions must emerge to prevent the imminent health crisis risk, and antibacterial hydrogels are one of them. In [...] Read more.
Nosocomial diseases are becoming a scourge in hospitals worldwide, and new multidrug-resistant microorganisms are appearing at the forefront, significantly increasing the number of deaths. Innovative solutions must emerge to prevent the imminent health crisis risk, and antibacterial hydrogels are one of them. In addition to this, for the past ten years, photochemistry has become an appealing green process attracting continuous attention from scientists in the scope of sustainable development, as it exhibits many advantages over other methods used in polymer chemistry. Therefore, the combination of antimicrobial hydrogels and light has become a matter of course to design innovative antimicrobial materials. In the present review, we focus on the use of photochemistry to highlight two categories of hydrogels: (a) antibacterial hydrogels synthesized via a free-radical photochemical crosslinking process and (b) chemical hydrogels with light-triggered antibacterial properties. Numerous examples of these new types of hydrogels are described, and some notions of photochemistry are introduced. Full article
(This article belongs to the Special Issue Advanced Antimicrobial Materials)
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18 pages, 1233 KiB  
Review
Science-Based Strategies of Antiviral Coatings with Viricidal Properties for the COVID-19 Like Pandemics
by Rakesh Pemmada, Xiaoxian Zhu, Madhusmita Dash, Yubin Zhou, Seeram Ramakrishna, Xinsheng Peng, Vinoy Thomas, Sanjeev Jain and Himansu Sekhar Nanda
Materials 2020, 13(18), 4041; https://doi.org/10.3390/ma13184041 - 11 Sep 2020
Cited by 78 | Viewed by 12327
Abstract
The worldwide, extraordinary outbreak of coronavirus pandemic (i.e., COVID-19) and other emerging viral expansions have drawn particular interest to the design and development of novel antiviral, and viricidal, agents, with a broad-spectrum of antiviral activity. The current indispensable challenge lies in the development [...] Read more.
The worldwide, extraordinary outbreak of coronavirus pandemic (i.e., COVID-19) and other emerging viral expansions have drawn particular interest to the design and development of novel antiviral, and viricidal, agents, with a broad-spectrum of antiviral activity. The current indispensable challenge lies in the development of universal virus repudiation systems that are reusable, and capable of inactivating pathogens, thus reducing risk of infection and transmission. In this review, science-based methods, mechanisms, and procedures, which are implemented in obtaining resultant antiviral coated substrates, used in the destruction of the strains of the different viruses, are reviewed. The constituent antiviral members are classified into a few broad groups, such as polymeric materials, metal ions/metal oxides, and functional nanomaterials, based on the type of materials used at the virus contamination sites. The action mode against enveloped viruses was depicted to vindicate the antiviral mechanism. We also disclose hypothesized strategies for development of a universal and reusable virus deactivation system against the emerging COVID-19. In the surge of the current, alarming scenario of SARS-CoV-2 infections, there is a great necessity for developing highly-innovative antiviral agents to work against the viruses. We hypothesize that some of the antiviral coatings discussed here could exert an inhibitive effect on COVID-19, indicated by the results that the coatings succeeded in obtaining against other enveloped viruses. Consequently, the coatings need to be tested and authenticated, to fabricate a wide range of coated antiviral products such as masks, gowns, surgical drapes, textiles, high-touch surfaces, and other personal protective equipment, aimed at extrication from the COVID-19 pandemic. Full article
(This article belongs to the Special Issue Advanced Antimicrobial Materials)
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