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Biomedical Polymers and Drug Delivery Systems
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Biomedical Polymers and Drug Delivery Systems

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 December 2023) | Viewed by 8971

Special Issue Editor

Prof. Dr. Cao Li

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Hubei University, Wuhan, China
Interests: drug delivery systems; cancer theranostics; controlled release

Special Issue Information

Dear Colleagues, 

The compelling, human side to biomaterials is that millions of lives are saved, and the quality of life is improved for millions more. Among all materials, functional polymers are some of the most suitable and widely researched materials for biomedical applications. To date, polymeric materials have been introduced as implant instruments, scaffolds for tissue engineering, drug and gene delivery systems, replacement materials for heart valves and arteries, antibacterial materials, biosensors, etc. Both natural and synthetic polymers with good biocompatibility and biological functions can be used in the biomedical field. 

This Special Issue, entitled Biomedical Polymers and Drug Delivery Systems, is intended to cover all recent aspects of the biomedical application of polymeric materials, including the application of synthetic polymers, natural polymers, and modified natural polymers in tissue engineering, drug and gene delivery, biosensing, antibacterial fields,etc., as well as the design, synthesis, characterization and the biomedical applications of novel biofunctional polymers. 

I kindly invite you to submit a manuscript for this Special Issue. Full papers, communications, and reviews are all welcome.

Prof. Dr. Cao Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • polymeric materials
  • biomaterials
  • biomedical
  • drug and gene delivery systems
  • tissue engineering
  • antibacterial materials
  • biosensors
  • theranostics

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Published Papers (4 papers)

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Research

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16 pages, 4600 KiB  
Article
Investigation and Characterization of Pickering Emulsion Stabilized by Alkali-Treated Zein (AZ)/Sodium Alginate (SA) Composite Particles
by Ying Kuang, Qinjian Xiao, Yichen Yang, Menglong Liu, Xiaosa Wang, Pengpeng Deng, Kao Wu, Yi Liu, Bo Peng, Fatang Jiang and Cao Li
Materials 2023, 16(8), 3164; https://doi.org/10.3390/ma16083164 - 17 Apr 2023
Cited by 8 | Viewed by 2362
Abstract
Pickering emulsions stabilized by food-grade colloidal particles have attracted increasing attention in recent years due to their “surfactant-free” nature. In this study, the alkali-treated zein (AZ) was prepared via restricted alkali deamidation and then combined with sodium alginate (SA) in different ratios to [...] Read more.
Pickering emulsions stabilized by food-grade colloidal particles have attracted increasing attention in recent years due to their “surfactant-free” nature. In this study, the alkali-treated zein (AZ) was prepared via restricted alkali deamidation and then combined with sodium alginate (SA) in different ratios to obtain AZ/SA composite particles (ZS), which were used to stabilize Pickering emulsion. The degree of deamidation (DD) and degree of hydrolysis (DH) of AZ were 12.74% and 6.58% respectively, indicating the deamidation occurred mainly in glutamine on the side chain of the protein. After the treatment with alkali, AZ particle size decreased significantly. Moreover, the particle size of ZS with different ratios was all less than 80 nm. when the AZ/SA ratio was 2:1(Z2S1) and 3:1(Z3S1), the three-phase contact angle (θo/w) were close to 90°, which was favorable for stabilizing the Pickering emulsion. Furthermore, at a high oil phase fraction (75%), Z3S1-stabilized Pickering emulsions showed the best long-term storage stability within 60 days. Confocal laser scanning microscope (CLSM) observations showed that the water-oil interface was wrapped by a dense layer of Z3S1 particles with non-agglomeration between independent oil droplets. At constant particle concentration, the apparent viscosity of the Pickering emulsions stabilized by Z3S1 gradually decreased with increasing oil phase fraction, and the oil-droplet size and the Turbiscan stability index (TSI) also gradually decreased, exhibiting solid-like behavior. This study provides new ideas for the fabrication of food-grade Pickering emulsions and will extend the future applications of zein-based Pickering emulsions as bioactive ingredient delivery systems. Full article
(This article belongs to the Special Issue Biomedical Polymers and Drug Delivery Systems)
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15 pages, 3208 KiB  
Article
Comparative Study of the Antibacterial, Biodegradable, and Biocompatibility Properties of Composite and Bi-Layer Films of Chitosan/Gelatin Coated with Silver Particles
by Laura-Elizabeth Valencia-Gómez, Hortensia Reyes-Blas, Juan-Francisco Hernández-Paz, Claudia-Alejandra Rodríguez-González and Imelda Olivas-Armendáriz
Materials 2023, 16(8), 3000; https://doi.org/10.3390/ma16083000 - 10 Apr 2023
Cited by 3 | Viewed by 1658
Abstract
The dressings are materials that can improve the wound-healing process in patients with medical issues. Polymeric films are frequently used as dressings with multiple biological properties. Chitosan and gelatin are the most used polymers in tissue regeneration processes. There are usually several configurations [...] Read more.
The dressings are materials that can improve the wound-healing process in patients with medical issues. Polymeric films are frequently used as dressings with multiple biological properties. Chitosan and gelatin are the most used polymers in tissue regeneration processes. There are usually several configurations of films for dressings, among which the composite (mixture of two or more materials) and layered ones stand out (layers). This study analyzed the antibacterial, degradable, and biocompatible properties of chitosan and gelatin films in 2 configurations, composite and bilayer, composite. In addition, a silver coating was added to enhance the antibacterial properties of both configurations. After the study, it was found that the bilayer films have a higher antibacterial activity than the composite films, having inhibition halos between 23% and 78% in Gram-negative bacteria. In addition, the bilayer films increased the fibroblast cell proliferation process, reaching up to 192% cell viability after 48 h of incubation. On the other hand, composite films have greater stability since they are thicker, with 276 µm, 243.8 µm, and 239 µm compared to 236 µm, 233 µm, and 219 µm thick for bilayer films; and a low degradation rate compared to bilayer films. Full article
(This article belongs to the Special Issue Biomedical Polymers and Drug Delivery Systems)
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14 pages, 3261 KiB  
Article
Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities
by Chaitany Jayprakash Raorane, Thirukumaran Periyasamy, Rajesh Haldhar, Shakila Parveen Asrafali, Vinit Raj and Seong-Cheol Kim
Materials 2023, 16(6), 2249; https://doi.org/10.3390/ma16062249 - 10 Mar 2023
Cited by 6 | Viewed by 1617
Abstract
Candida albicans are highly widespread pathogenic fungi in humans. Moreover, its developed biofilm causes serious clinical problems, leading to drug failure caused by its inherent drug tolerance. Hence, the inhibition of biofilm formation and virulence characteristics provide other means of addressing infections. Polymer [...] Read more.
Candida albicans are highly widespread pathogenic fungi in humans. Moreover, its developed biofilm causes serious clinical problems, leading to drug failure caused by its inherent drug tolerance. Hence, the inhibition of biofilm formation and virulence characteristics provide other means of addressing infections. Polymer composites (PCs) derived from natural products have attracted increasing interest in the scientific community, including antimicrobial applications. PCs are a good alternative approach to solving this challenge because of their excellent penetration power inside biofilms. The main objectives of this study were to synthesize a novel curcumin-based polybenzoxazine polymer composite (poly(Cu-A) PC) using Mannich condensation reaction and evaluate their potency as an antibiofilm and anticorrosive candidate against C. albicans. In addition, their anticorrosive efficacy was also explored. PC exhibited significant antibiofilm efficacy versus C. albicans DAY185 by the morphologic changing of yeast to hyphae, and>90% anticorrosive efficacy was observed at a higher dose of PC. These prepared PC were safe in vivo against Caenorhabditis elegans and Raphanus raphanistrum. The study shows that a polybenzoxazine polymer composite has the potential for controlling biofilm-associated fungal infections and virulence by C. albicans, and opens a new avenue for designing PCs as antifungal, anticorrosive agents for biofilm-associated fungal infections and industrial remediation. Full article
(This article belongs to the Special Issue Biomedical Polymers and Drug Delivery Systems)
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Review

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23 pages, 3205 KiB  
Review
Drug Delivery Systems with a “Tumor-Triggered” Targeting or Intracellular Drug Release Property Based on DePEGylation
by Zhe Ren, Tao Liao, Cao Li and Ying Kuang
Materials 2022, 15(15), 5290; https://doi.org/10.3390/ma15155290 - 31 Jul 2022
Cited by 6 | Viewed by 2340
Abstract
Coating nanosized anticancer drug delivery systems (DDSs) with poly(ethylene glycol) (PEG), the so-called PEGylation, has been proven an effective method to enhance hydrophilicity, aqueous dispersivity, and stability of DDSs. What is more, as PEG has the lowest level of protein absorption of any [...] Read more.
Coating nanosized anticancer drug delivery systems (DDSs) with poly(ethylene glycol) (PEG), the so-called PEGylation, has been proven an effective method to enhance hydrophilicity, aqueous dispersivity, and stability of DDSs. What is more, as PEG has the lowest level of protein absorption of any known polymer, PEGylation can reduce the clearance of DDSs by the mononuclear phagocyte system (MPS) and prolong their blood circulation time in vivo. However, the “stealthy” characteristic of PEG also diminishes the uptake of DDSs by cancer cells, which may reduce drug utilization. Therefore, dynamic protection strategies have been widely researched in the past years. Coating DDSs with PEG through dynamic covalent or noncovalent bonds that are stable in blood and normal tissues, but can be broken in the tumor microenvironment (TME), can achieve a DePEGylation-based “tumor-triggered” targeting or intracellular drug release, which can effectively improve the utilization of drugs and reduce their side effects. In this review, the stimuli and methods of “tumor-triggered” targeting or intracellular drug release, based on DePEGylation, are summarized. Additionally, the targeting and intracellular controlled release behaviors of the DDSs are briefly introduced. Full article
(This article belongs to the Special Issue Biomedical Polymers and Drug Delivery Systems)
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