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Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and...
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Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and Innovative Materials for Dentistry and Oral Health

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (10 July 2022) | Viewed by 17740

Special Issue Editors

Prof. Dr. Francesco Inchingolo

E-Mail Website
Guest Editor
Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Interests: stem cells regeneration tissue; dental disease; dental biomaterials; orthodontic diseases; orthodontic innovation; oral surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Gianna Dipalma

E-Mail Website
Guest Editor
Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: stem cells regeneration tissue; dental disease; dental biomaterials; orthodontic diseases; orthodontic innovation; oral surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Ioana-Roxana Bordea

E-Mail Website
Guest Editor
Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: oral health; laser in dentistry; laser coagulatio; laser therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent updates in the development, manufacturing, and characterization of innovative materials for oral and cranio-facial reconstructive medicine are producing a new generation of constructs with physicochemical properties, improved wettability, hierarchical porosity, increased mechanical performance, and integration with the host tissues. Moreover, the creation of constructs based on autologous growth factors derivates and bioactive molecules are able to promote the healing of soft and hard tissues to obtain functional and aesthetic harmony rehabilitation of the jaws and the face.

This Special Issue entitled "Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds, and Innovative Materials for Dentistry and Oral Health" will evaluate novel frontiers in craniofacial research and oral health regarding bone substitutes, autologous tooth, scaffolds, multifunctional materials, innovative bio-complexes and growth factors derivates constructs, stem cells, surface treatments, and novel protocols for implant-supported rehabilitations and tissular damage repair of the face and the jaws.

In particular, in vivo and in vitro original research and breakthroughs for biomedical applications reports, finite elements and mechanical studies, and literature reviews will be considered for the issue.

Prof. Dr. Francesco Inchingolo
Dr. Gianna Dipalma
Prof. Dr. Ioana-Roxana Bordea
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • platelet growth factors
  • blood derivates
  • stem cells
  • bone regeneration
  • bone graft
  • tissue engineering
  • dental implant
  • microbiota
  • bioactive biomaterials
  • autologous tooth

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Published Papers (4 papers)

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Research

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11 pages, 2612 KiB  
Article
Influence of Xenogeneic and Alloplastic Carriers for Bone Augmentation on Human Unrestricted Somatic Stem Cells
by Lara Schorn, Anna Sine, Karin Berr, Jörg Handschel, Rita Depprich, Norbert R. Kübler, Christoph Sproll, Majeed Rana and Julian Lommen
Materials 2022, 15(14), 4779; https://doi.org/10.3390/ma15144779 - 7 Jul 2022
Viewed by 1700
Abstract
Alloplastic and xenogeneic bone grafting materials are frequently used for bone augmentation. The effect of these materials on precursor cells for bone augmentation is yet to be determined. The aim of this study was to ascertain, in vitro, how augmentation materials influence the [...] Read more.
Alloplastic and xenogeneic bone grafting materials are frequently used for bone augmentation. The effect of these materials on precursor cells for bone augmentation is yet to be determined. The aim of this study was to ascertain, in vitro, how augmentation materials influence the growth rates and viability of human unrestricted somatic stem cells. The biocompatibility of two xenogeneic and one alloplastic bone graft was tested using human unrestricted somatic stem cells (USSCs). Proliferation, growth, survival and attachment of unrestricted somatic stem cells were monitored after 24 h, 48 h and 7 days. Furthermore, cell shape and morphology were evaluated by SEM. Scaffolds were assessed for their physical properties by Micro-CT imaging. USSCs showed distinct proliferation on the different carriers. Greatest proliferation was observed on the xenogeneic carriers along with improved viability of the cells. Pore sizes of the scaffolds varied significantly, with the xenogeneic materials providing greater pore sizes than the synthetic inorganic material. Unrestricted somatic stem cells in combination with a bovine collagenous bone block seem to be very compatible. A scaffold’s surface morphology, pore size and bioactive characteristics influence the proliferation, attachment and viability of USSCs. Full article
(This article belongs to the Special Issue Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and Innovative Materials for Dentistry and Oral Health)
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11 pages, 1496 KiB  
Article
“Sticky Bone” Preparation Device: A Pilot Study on the Release of Cytokines and Growth Factors
by Ezio Gheno, Gutemberg Gomes Alves, Roberto Ghiretti, Rafael Coutinho Mello-Machado, Antonio Signore, Emanuelle Stellet Lourenço, Paulo Emílio Correa Leite, Carlos Fernando de Almeida Barros Mourão, Dong-Seok Sohn and Mônica Diuana Calasans-Maia
Materials 2022, 15(4), 1474; https://doi.org/10.3390/ma15041474 - 16 Feb 2022
Cited by 14 | Viewed by 6231
Abstract
Sticky bone, a growth factor-enriched bone graft matrix, is a promising autologous material for bone tissue regeneration. However, its production is strongly dependent on manual handling steps. In this sense, a new device was developed to simplify the confection of the sticky bone, [...] Read more.
Sticky bone, a growth factor-enriched bone graft matrix, is a promising autologous material for bone tissue regeneration. However, its production is strongly dependent on manual handling steps. In this sense, a new device was developed to simplify the confection of the sticky bone, named Sticky Bone Preparation Device (SBPD®). The purpose of this pilot study was to investigate the suitability of the SBPD® to prepare biomaterials for bone regeneration with autologous platelet concentrates. The SBPD® allows the blending of particulate samples from synthetic, xenograft, or autogenous bone with autologous platelet concentrates, making it easy to use and avoiding the need of further manipulations for the combination of the materials. The protocol for the preparation of sticky bone samples using the SBPD® is described, and the resulting product is compared with hand-mixed SB preparations regarding in vitro parameters such as cell content and the ability to release growth factors and cytokines relevant to tissue regeneration. The entrapped cell content was estimated, and the ability to release biological mediators was assessed after 7 days of incubation in culture medium. Both preparations increased the leukocyte and platelet concentrations compared to whole-blood samples (p < 0.05), without significant differences between SB and SBPD®. SBPD® samples released several growth factors, including VEGF, FGFb, and PDGF, at concentrations physiologically equivalent to those released by SB preparations. Therefore, the use of SBPD® results in a similar product to the standard protocol, but with more straightforward and shorter preparation times and less manipulation. These preliminary results suggest this device as a suitable alternative for combining bone substitute materials with platelet concentrates for bone tissue regeneration. Full article
(This article belongs to the Special Issue Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and Innovative Materials for Dentistry and Oral Health)
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11 pages, 4401 KiB  
Article
Augmentation Stability of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with L-shaped Porcine-Derived Block Bone Substitute
by Jae-Hong Lee, Eun-Hee Jung and Seong-Nyum Jeong
Materials 2021, 14(21), 6580; https://doi.org/10.3390/ma14216580 - 2 Nov 2021
Cited by 6 | Viewed by 2916
Abstract
Block bone substitutes have better augmentation stability for guided bone regeneration (GBR) than particulate bone substitutes. This study sought to determine whether GBR with an L-shaped porcine block bone (DPBM-C) differs from GBR with an L-shaped bovine block bone (DBBM-C) based on clinical, [...] Read more.
Block bone substitutes have better augmentation stability for guided bone regeneration (GBR) than particulate bone substitutes. This study sought to determine whether GBR with an L-shaped porcine block bone (DPBM-C) differs from GBR with an L-shaped bovine block bone (DBBM-C) based on clinical, radiographic, and volumetric outcomes for peri-implant dehiscence defects. A total of 42 peri-implant defects were grafted with 20 L-shaped DPBM-C and 22 DBBM-C groups. The horizontal and vertical thicknesses of the augmented hard tissue were measured using sagittal cone-beam computed tomography, and the volumetric tissue change was evaluated by stereolithography image superimposition. Postoperative discomfort, early wound healing outcomes, and implant stability were also assessed. Among the clinical (subjective pain and swelling, wound dehiscence, membrane exposure, and periotest values), radiographic (changes in horizontal and vertical hard tissue thickness), and volumetric parameters of the L-shaped DPBM-C and DBBM-C groups during the healing period, only the periotest values showed a statistically significant difference (0.67 ± 1.19, p = 0.042). Within the limitations of this study, an L-shaped DPBM-C is not inferior to an L-shaped DBBM-C based on their clinical, radiographic, and volumetric outcomes for GBR of peri-implant dehiscence defects. Full article
(This article belongs to the Special Issue Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and Innovative Materials for Dentistry and Oral Health)
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Review

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43 pages, 1612 KiB  
Review
Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review
by Francesco Inchingolo, Denisa Hazballa, Alessio Danilo Inchingolo, Giuseppina Malcangi, Grazia Marinelli, Antonio Mancini, Maria Elena Maggiore, Ioana Roxana Bordea, Antonio Scarano, Marco Farronato, Gianluca Martino Tartaglia, Felice Lorusso, Angelo Michele Inchingolo and Gianna Dipalma
Materials 2022, 15(3), 1120; https://doi.org/10.3390/ma15031120 - 31 Jan 2022
Cited by 47 | Viewed by 5722
Abstract
Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on [...] Read more.
Background: For decades, regenerative medicine and dentistry have been improved with new therapies and innovative clinical protocols. The aim of the present investigation was to evaluate through a critical review the recent innovations in the field of bone regeneration with a focus on the healing potentials and clinical protocols of bone substitutes combined with engineered constructs, growth factors and photobiomodulation applications. Methods: A Boolean systematic search was conducted by PubMed/Medline, PubMed/Central, Web of Science and Google scholar databases according to the PRISMA guidelines. Results: After the initial screening, a total of 304 papers were considered eligible for the qualitative synthesis. The articles included were categorized according to the main topics: alloplastic bone substitutes, autologous teeth derived substitutes, xenografts, platelet-derived concentrates, laser therapy, microbiota and bone metabolism and mesenchymal cells construct. Conclusions: The effectiveness of the present investigation showed that the use of biocompatible and bio-resorbable bone substitutes are related to the high-predictability of the bone regeneration protocols, while the oral microbiota and systemic health of the patient produce a clinical advantage for the long-term success of the regeneration procedures and implant-supported restorations. The use of growth factors is able to reduce the co-morbidity of the regenerative procedure ameliorating the post-operative healing phase. The LLLT is an adjuvant protocol to improve the soft and hard tissues response for bone regeneration treatment protocols. Full article
(This article belongs to the Special Issue Frontiers and Novel Applications in Advanced Autologous Constructs, Scaffolds and Innovative Materials for Dentistry and Oral Health)
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